Published in Proc Natl Acad Sci U S A on December 11, 2002
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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron (2013) 3.63
An evaluation of human protein-protein interaction data in the public domain. BMC Bioinformatics (2006) 3.33
Prp8 protein: at the heart of the spliceosome. RNA (2005) 2.89
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol (2006) 2.55
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Sequence information for the splicing of human pre-mRNA identified by support vector machine classification. Genome Res (2003) 2.42
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Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes. EMBO J (2004) 2.17
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Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell (2005) 2.05
Exon inclusion is dependent on predictable exonic splicing enhancers. Mol Cell Biol (2005) 2.02
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. RNA (2006) 1.89
Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. RNA (2010) 1.85
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The splicing ATPase prp43p is a component of multiple preribosomal particles. Mol Cell Biol (2005) 1.82
RNA-based affinity purification reveals 7SK RNPs with distinct composition and regulation. RNA (2007) 1.77
The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis. Mol Cell Biol (2006) 1.70
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA (2004) 1.67
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol (2008) 1.64
Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol Cell Biol (2006) 1.64
Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation. RNA (2004) 1.63
Nuclear factors are involved in hepatitis C virus RNA replication. RNA (2007) 1.58
RNA splicing capability of live neuronal dendrites. Proc Natl Acad Sci U S A (2005) 1.46
Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol (2010) 1.39
Efficient detection of RNA-protein interactions using tethered RNAs. Nucleic Acids Res (2011) 1.39
Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener (2008) 1.38
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion. Nat Commun (2012) 1.35
A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing. Mol Cell Biol (2007) 1.30
A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts. Mol Cell Biol (2005) 1.22
Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic Acids Res (2007) 1.21
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes. Mol Cell Biol (2006) 1.18
Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. Mol Cell Biol (2004) 1.16
The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing. Biochem Soc Trans (2010) 1.16
Minor spliceosome components are predominantly localized in the nucleus. Proc Natl Acad Sci U S A (2008) 1.16
YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. Nucleic Acids Res (2004) 1.16
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA (2008) 1.16
Methods for comprehensive experimental identification of RNA-protein interactions. Genome Biol (2014) 1.16
In vivo expression and purification of aptamer-tagged small RNA regulators. Nucleic Acids Res (2009) 1.15
Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA (2011) 1.14
Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J Virol (2009) 1.14
Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling. J Biol Chem (2012) 1.13
The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine. Proteomics (2010) 1.13
RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site. Mol Cell Biol (2011) 1.12
Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex. Mol Cell Biol (2008) 1.11
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. PLoS One (2009) 1.11
IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. RNA (2009) 1.10
The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex. Mol Cell Biol (2003) 1.10
ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome. Mol Cell Biol (2005) 1.10
p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. RNA (2006) 1.09
Isolation and characterization of post-splicing lariat-intron complexes. Nucleic Acids Res (2008) 1.09
SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. Nucleic Acids Res (2005) 1.08
The role of FUS gene variants in neurodegenerative diseases. Nat Rev Neurol (2014) 1.04
Exon, intron and splice site locations in the spliceosomal B complex. EMBO J (2009) 1.04
Nonmuscle myosin-dependent synthesis of type I collagen. J Mol Biol (2010) 1.04
Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP. RNA (2006) 1.04
The function of spliceosome components in open mitosis. Nucleus (2010) 1.01
Spliceosome database: a tool for tracking components of the spliceosome. Nucleic Acids Res (2012) 1.01
Rational design of antisense oligomers to induce dystrophin exon skipping. Mol Ther (2009) 1.01
Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair. PLoS Genet (2006) 1.01
RNA-protein analysis using a conditional CRISPR nuclease. Proc Natl Acad Sci U S A (2013) 1.00
An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins. Nucleic Acids Res (2013) 1.00
Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs. Nucleic Acids Res (2011) 0.99
Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA (2006) 0.99
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. Proc Natl Acad Sci U S A (2015) 0.99
Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing. Genetics (2008) 0.97
Identification of DEAD-box RNA helicase 6 (DDX6) as a cellular modulator of vascular endothelial growth factor expression under hypoxia. J Biol Chem (2013) 0.96
Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. Mol Cell Biol (2004) 0.95
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda. Proc Natl Acad Sci U S A (2004) 0.94
YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts. Nucleic Acids Res (2012) 0.94
The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proc Natl Acad Sci U S A (2009) 0.94
Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. J Biol Chem (2008) 0.91
Cajal bodies are linked to genome conformation. Nat Commun (2016) 0.89
Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3. Nucleic Acids Res (2006) 0.89
The dual use of RNA aptamer sequences for affinity purification and localization studies of RNAs and RNA-protein complexes. Methods Mol Biol (2011) 0.88
Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol (2006) 0.88
Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Nucleic Acids Res (2011) 0.87
Proline-rich sequence recognition: I. Marking GYF and WW domain assembly sites in early spliceosomal complexes. Mol Cell Proteomics (2009) 0.87
Plant SMU-1 and SMU-2 homologues regulate pre-mRNA splicing and multiple aspects of development. Plant Physiol (2009) 0.87
Impact of gentamicin-supplemented polyvinylidenfluoride mesh materials on MMP-2 expression and tissue integration in a transgenic mice model. Langenbecks Arch Surg (2010) 0.87
The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet (2011) 0.87
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. Proc Natl Acad Sci U S A (2004) 0.87
Analysis of site-specific protein-RNA cross-links in isolated RNP complexes, combining affinity selection and mass spectrometry. RNA (2003) 0.86
Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants. EMBO J (2016) 0.86
A mechanism for incorporation of galectin-3 into the spliceosome through its association with U1 snRNP. Biochemistry (2009) 0.86
Cancer-relevant splicing factor CAPERα engages the essential splicing factor SF3b155 in a specific ternary complex. J Biol Chem (2014) 0.85
The biology of DHX9 and its potential as a therapeutic target. Oncotarget (2016) 0.84
XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic Acids Res (2006) 0.83
Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. PLoS One (2014) 0.83
A survey of splice variants of the human hypoxanthine phosphoribosyl transferase and DNA polymerase beta genes: products of alternative or aberrant splicing? Nucleic Acids Res (2004) 0.83
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA (2013) 0.83
An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains. Proc Natl Acad Sci U S A (2003) 0.83
TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. Dev Dyn (2012) 0.82
NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins. Nucleic Acids Res (2013) 0.82
Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. J Biol Chem (2009) 0.82
TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization. Int J Mol Sci (2008) 0.80
RNA-Binding Proteins: Splicing Factors and Disease. Biomolecules (2015) 0.80
Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5. Chembiochem (2011) 0.80
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
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Comprehensive proteomic analysis of the human spliceosome. Nature (2002) 6.85
Large-scale proteomic analysis of the human spliceosome. Genome Res (2002) 5.75
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature (2000) 5.57
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Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing. Science (1992) 3.94
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Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature (2001) 3.35
Delineation of mRNA export pathways by the use of cell-permeable peptides. Science (2001) 2.87
In vitro assembly of yeast U6 snRNP: a functional assay. Genes Dev (1989) 2.42
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Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem (1998) 2.21
Identification of an RNA binding specificity for the potential splicing factor TLS. J Biol Chem (2000) 2.10
The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J (2001) 1.92
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Specific binding of aminoglycoside antibiotics to RNA. Chem Biol (1995) 1.63
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The spliceosome: design principles of a dynamic RNP machine. Cell (2009) 12.82
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (2004) 12.75
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
RNAi-mediated gene silencing in non-human primates. Nature (2006) 7.60
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol (2008) 6.81
Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov (2007) 6.37
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The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA (2002) 5.73
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA (2005) 4.99
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A (2008) 4.57
Spliceosome structure and function. Cold Spring Harb Perspect Biol (2011) 4.01
Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell (2006) 3.98
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell (2004) 3.95
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell (2003) 3.58
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene. EMBO Rep (2002) 3.43
Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Cell (2008) 3.18
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Isolation of an active step I spliceosome and composition of its RNP core. Nature (2008) 3.10
Macromolecular-scale resolution in biological fluorescence microscopy. Proc Natl Acad Sci U S A (2006) 3.04
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GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods (2007) 2.71
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70
Molecular architecture of the multiprotein splicing factor SF3b. Science (2003) 2.63
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol (2004) 2.59
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Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J (2007) 2.49
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science (2012) 2.44
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol Cell (2008) 2.39
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell (2009) 2.39
Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. Mol Cell Biol (2002) 2.37
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol (2006) 2.29
Splicing of a rare class of introns by the U12-dependent spliceosome. Biol Chem (2005) 2.20
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J (2004) 2.20
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Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol Cell (2008) 2.15
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing. EMBO J (2002) 2.11
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RanGTP mediates nuclear pore complex assembly. Nature (2003) 2.08
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. EMBO J (2007) 2.07
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Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell (2012) 2.04
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science (2011) 2.03
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol Biol Cell (2006) 1.95
Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell (2008) 1.91
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell (2004) 1.89
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat Struct Mol Biol (2009) 1.89
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. RNA (2006) 1.89
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Mol Cell (2010) 1.84
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A cytoplasmic complex mediates specific mRNA recognition and localization in yeast. PLoS Biol (2011) 1.78
A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat Biotechnol (2011) 1.74
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RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. EMBO J (2004) 1.73
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nat Struct Mol Biol (2008) 1.73