The Bacillus anthracis cholesterol-dependent cytolysin, Anthrolysin O, kills human neutrophils, monocytes and macrophages.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1550246)

Published in BMC Microbiol on June 21, 2006

Authors

Elise M Mosser1, Richard F Rest

Author Affiliations

1: Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, USA. emb39@drexel.edu

Articles citing this

The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15

Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev (2013) 1.91

Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins. Proc Natl Acad Sci U S A (2010) 1.62

Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner. J Leukoc Biol (2009) 1.40

Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry (2009) 1.39

Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem (2009) 1.25

Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum. Expert Rev Vaccines (2008) 1.13

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi. Nat Rev Microbiol (2015) 1.09

Human lung innate immune response to Bacillus anthracis spore infection. Infect Immun (2007) 1.08

Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun (2009) 1.01

The pore-forming haemolysins of bacillus cereus: a review. Toxins (Basel) (2013) 0.98

Passive administration of monoclonal antibodies to anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis. BMC Microbiol (2008) 0.93

The role of anthrolysin O in gut epithelial barrier disruption during Bacillus anthracis infection. Biochem Biophys Res Commun (2010) 0.92

Selective killing of HIV-1-positive macrophages and T cells by the Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis. Retrovirology (2008) 0.90

Bacillus anthracis factors for phagosomal escape. Toxins (Basel) (2012) 0.86

Activation of the latent PlcR regulon in Bacillus anthracis. Microbiology (2010) 0.84

Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA. J Immunol (2012) 0.82

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion. Infect Immun (2016) 0.82

Unexpected Roles for Toll-Like Receptor 4 and TRIF in Intraocular Infection with Gram-Positive Bacteria. Infect Immun (2015) 0.77

Bacterial Toxins as Pathogen Weapons Against Phagocytes. Front Microbiol (2016) 0.77

Bacterial Virulence Factors: Secreted for Survival. Indian J Microbiol (2016) 0.77

Articles cited by this

Anthrax. Annu Rev Microbiol (2001) 9.69

Anthrax. N Engl J Med (1999) 8.89

Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg Infect Dis (2002) 5.23

Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature (1990) 4.58

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A (2003) 4.56

Sequence and organization of pXO1, the large Bacillus anthracis plasmid harboring the anthrax toxin genes. J Bacteriol (1999) 4.50

Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infect Immun (1983) 3.85

Activation of human complement by the pneumococcal toxin pneumolysin. Infect Immun (1984) 3.47

Early Bacillus anthracis-macrophage interactions: intracellular survival survival and escape. Cell Microbiol (2000) 3.11

Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria. Cell (2001) 2.70

Construction and characterization of a protective antigen-deficient Bacillus anthracis strain. Mol Microbiol (1990) 2.67

Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol (2004) 2.66

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets. Infect Immun (1981) 2.39

Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med (2004) 2.32

Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility. Infect Immun (2004) 2.14

Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun (1992) 1.91

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86

Anthrax pathogenesis and host response. Curr Top Microbiol Immunol (1998) 1.83

Characterization of anthrolysin O, the Bacillus anthracis cholesterol-dependent cytolysin. Infect Immun (2003) 1.81

Suppression of chemotatic activity of human neutrophils by streptolysin O. J Infect Dis (1972) 1.74

Toxins of Bacillus anthracis. Toxicon (2001) 1.74

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A (2005) 1.63

The biology of CSF-1 and its receptor. Curr Top Microbiol Immunol (1992) 1.55

Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues. Infect Immun (2004) 1.43

Thiol-activated cytolysins: structure, function and role in pathogenesis. FEMS Microbiol Lett (2000) 1.39

Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci. Infect Immun (2003) 1.34

Cholesterol-binding cytolytic protein toxins. Int J Med Microbiol (2000) 1.26

Anaerobic induction of Bacillus anthracis hemolytic activity. Biochem Biophys Res Commun (2003) 1.14

Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infect Immun (2002) 1.12

Streptococcus suis interactions with the murine macrophage cell line J774: adhesion and cytotoxicity. Infect Immun (2002) 1.11

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils. Infect Immun (2001) 1.09

Cholesterol and the activity of bacterial toxins. FEMS Microbiol Lett (2004) 1.01

Measurement of nonopsonic phagocytic killing by human and mouse phagocytes. Methods Enzymol (1994) 1.01

Cytolysins and the intracellular life of bacteria. Trends Microbiol (1997) 0.99

Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors. BMC Microbiol (2006) 0.95

Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. J Biol Chem (2006) 0.95

An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence. Infect Immun (1999) 0.91

Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis. Infect Immun (2005) 0.91

Different sensitivity to streptolysin-O of cells in macrophage lineage. Microbiol Immunol (1996) 0.83

Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. J Mol Recognit (2006) 0.83

Articles by these authors

Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med (2004) 2.32

Characterization of anthrolysin O, the Bacillus anthracis cholesterol-dependent cytolysin. Infect Immun (2003) 1.81

Genome analysis and strain comparison of correia repeats and correia repeat-enclosed elements in pathogenic Neisseria. J Bacteriol (2002) 1.44

Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem (2009) 1.25

The Neisseria lipooligosaccharide-specific alpha-2,3-sialyltransferase is a surface-exposed outer membrane protein. Infect Immun (2002) 1.01

Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun (2009) 1.01

Characterization of Bacillus anthracis arginase: effects of pH, temperature, and cell viability on metal preference. BMC Biochem (2008) 0.99

Passive administration of monoclonal antibodies to anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis. BMC Microbiol (2008) 0.93

NLRP3 inflammasome is a target for development of broad-spectrum anti-infective drugs. Antimicrob Agents Chemother (2012) 0.90

Differential expression and transcriptional analysis of the alpha-2,3-sialyltransferase gene in pathogenic Neisseria spp. Infect Immun (2006) 0.88

1-Peptidyl-2-arachidonoyl-3-stearoyl-sn-glyceride: an immunologically active lipopeptide from goat serum (Capra hircus) is an endogenous damage-associated molecular pattern. J Nat Prod (2009) 0.85

Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. J Mol Recognit (2006) 0.83

Rapid sporulation of Bacillus anthracis in a high iron, glucose-free medium. J Microbiol Methods (2010) 0.77

Control of pili and sialyltransferase expression in Neisseria gonorrhoeae is mediated by the transcriptional regulator CrgA. Mol Microbiol (2014) 0.76

Array lead zirconate titanate/glass piezoelectric microcantilevers for real-time detection of Bacillus anthracis with 10 spores/ml sensitivity and 1/1000 selectivity in bacterial mixtures. Rev Sci Instrum (2009) 0.75

Bactericidal activity of chlorine-loaded carbide-derived carbon against Escherichia coli and Bacillus anthracis. J Biomed Mater Res A (2008) 0.75