Published in Lab Chip on April 20, 2006
Microfluidic devices for measuring gene network dynamics in single cells. Nat Rev Genet (2009) 2.52
Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. Lab Chip (2009) 1.53
Biology by design: reduction and synthesis of cellular components and behaviour. J R Soc Interface (2007) 1.33
Going local: technologies for exploring bacterial microenvironments. Nat Rev Microbiol (2013) 1.19
The renaissance of continuous culture in the post-genomics age. J Ind Microbiol Biotechnol (2010) 1.10
Culturing aerobic and anaerobic bacteria and mammalian cells with a microfluidic differential oxygenator. Anal Chem (2009) 1.01
Oxygen transfer characteristics of miniaturized bioreactor systems. Biotechnol Bioeng (2013) 0.98
Review of microfluidic microbioreactor technology for high-throughput submerged microbiological cultivation. Biomicrofluidics (2013) 0.93
A Small-Volume, Low-Cost, and Versatile Continuous Culture Device. PLoS One (2015) 0.84
Measuring competitive fitness in dynamic environments. J Phys Chem B (2013) 0.79
A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production. Lab Chip (2015) 0.76
Evolutionary pressures on microbial metabolic strategies in the chemostat. Sci Rep (2016) 0.75
Microfluidic landscapes for evolution. Curr Opin Chem Biol (2010) 0.75
A lab-on-a-chip for hypoxic patch clamp measurements combined with optical tweezers and spectroscopy- first investigations of single biological cells. Biomed Eng Online (2015) 0.75
Cell engineering and molecular pharming for biopharmaceuticals. Open Med Chem J (2008) 0.75
Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. PLoS One (2017) 0.75
Role of growth rate on the orientational alignment of Escherichia coli in a slit. R Soc Open Sci (2017) 0.75
Cells on chips. Nature (2006) 8.40
A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A (2013) 2.40
Microfluidic shear devices for quantitative analysis of cell adhesion. Anal Chem (2004) 1.95
Design and global optimization of high-efficiency thermophotovoltaic systems. Opt Express (2010) 1.91
An integrated microreactor system for self-optimization of a Heck reaction: from micro- to mesoscale flow systems. Angew Chem Int Ed Engl (2010) 1.77
Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. Lab Chip (2006) 1.74
A microfluidic electroporation device for cell lysis. Lab Chip (2004) 1.66
Transport and reaction in microscale segmented gas-liquid flow. Lab Chip (2004) 1.64
The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production. J Bacteriol (2002) 1.60
Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis. Angew Chem Int Ed Engl (2011) 1.51
Ralstonia eutropha H16 encodes two and possibly three intracellular Poly[D-(-)-3-hydroxybutyrate] depolymerase genes. J Bacteriol (2003) 1.46
Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. Annu Rev Biochem (2005) 1.45
Integrated microreactors for reaction automation: new approaches to reaction development. Annu Rev Anal Chem (Palo Alto Calif) (2010) 1.43
Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. Angew Chem Int Ed Engl (2007) 1.42
Synthesis of micro and nanostructures in microfluidic systems. Chem Soc Rev (2010) 1.40
Micromixing of miscible liquids in segmented gas-liquid flow. Langmuir (2005) 1.36
Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A (2003) 1.36
Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem (2009) 1.34
Flow-induced deformation of shallow microfluidic channels. Lab Chip (2006) 1.34
Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS Genet (2011) 1.30
Directed mutagenesis and plasmid-based complementation in the methanogenic archaeon Methanosarcina acetivorans C2A demonstrated by genetic analysis of proline biosynthesis. J Bacteriol (2002) 1.29
Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol (2005) 1.24
Microfluidic synthesis of colloidal silica. Langmuir (2004) 1.23
Continuous dielectrophoretic size-based particle sorting. Anal Chem (2006) 1.21
Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression. J Bacteriol (2010) 1.18
High-cell-density batch fermentation of Rhodococcus opacus PD630 using a high glucose concentration for triacylglycerol production. J Biotechnol (2010) 1.15
End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation. Angew Chem Int Ed Engl (2013) 1.15
A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics (2006) 1.15
Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip (2006) 1.15
Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture. Lab Chip (2011) 1.14
Microchemical systems for continuous-flow synthesis. Lab Chip (2009) 1.14
Analysis of transient polyhydroxybutyrate production in Wautersia eutropha H16 by quantitative Western analysis and transmission electron microscopy. J Bacteriol (2005) 1.14
Microfluidics-based assessment of cell deformability. Anal Chem (2012) 1.13
Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem (2005) 1.09
Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16. J Bacteriol (2010) 1.09
Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip (2005) 1.09
A microfabricated device for subcellular organelle sorting. Anal Chem (2004) 1.09
Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol (2013) 1.08
Microfluidic based single cell microinjection. Lab Chip (2008) 1.08
Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng (2004) 1.08
Integrated continuous microfluidic liquid-liquid extraction. Lab Chip (2006) 1.07
Reactive polymer coatings: a first step toward surface engineering of microfluidic devices. Anal Chem (2003) 1.06
Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions. Angew Chem Int Ed Engl (2007) 1.06
A microfabricated gas-liquid segmented flow reactor for high-temperature synthesis: the case of CdSe quantum dots. Angew Chem Int Ed Engl (2005) 1.03
Toward high-energy-density, high-efficiency, and moderate-temperature chip-scale thermophotovoltaics. Proc Natl Acad Sci U S A (2013) 1.01
Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil by engineered Ralstonia eutropha strains. Appl Environ Microbiol (2011) 1.01
Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation. Appl Microbiol Biotechnol (2005) 1.01
Whole-genome microarray and gene deletion studies reveal regulation of the polyhydroxyalkanoate production cycle by the stringent response in Ralstonia eutropha H16. Appl Environ Microbiol (2012) 1.00
Rhodostreptomycins, antibiotics biosynthesized following horizontal gene transfer from Streptomyces padanus to Rhodococcus fascians. J Am Chem Soc (2008) 1.00
Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med (2003) 0.99
Potential of Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol. Appl Microbiol Biotechnol (2006) 0.99
Investigation of indium phosphide nanocrystal synthesis using a high-temperature and high-pressure continuous flow microreactor. Angew Chem Int Ed Engl (2010) 0.98
Micro free-flow IEF enhanced by active cooling and functionalized gels. Electrophoresis (2006) 0.98
Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. Biochemistry (2012) 0.98
Microreactor-based reaction optimization in organic chemistry--glycosylation as a challenge. Chem Commun (Camb) (2004) 0.97
Suzuki-Miyaura cross-coupling reactions in flow: multistep synthesis enabled by a microfluidic extraction. Angew Chem Int Ed Engl (2011) 0.97
Studies on the production of branched-chain alcohols in engineered Ralstonia eutropha. Appl Microbiol Biotechnol (2012) 0.97
Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase. Biochemistry (2005) 0.95
Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation. Anal Chem (2010) 0.95
In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. Biomacromolecules (2005) 0.95
A clock reaction based on molybdenum blue. J Phys Chem A (2013) 0.94
Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device. Nano Lett (2012) 0.93
Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium. J Pharm Sci (2014) 0.92
Size-controlled flow synthesis of gold nanoparticles using a segmented flow microfluidic platform. Langmuir (2012) 0.92
Cascaded free-flow isoelectric focusing for improved focusing speed and resolution. Anal Chem (2007) 0.91
Engineered Corynebacterium glutamicum as an endotoxin-free platform strain for lactate-based polyester production. Appl Microbiol Biotechnol (2011) 0.91
Characterization of the highly active polyhydroxyalkanoate synthase of Chromobacterium sp. strain USM2. Appl Environ Microbiol (2011) 0.91
Rapid flow-based peptide synthesis. Chembiochem (2014) 0.91
Gene expression analysis of Escherichia coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data. Appl Microbiol Biotechnol (2005) 0.91
Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. Biochemistry (2005) 0.90
Insights into the kinetics of semiconductor nanocrystal nucleation and growth. J Am Chem Soc (2009) 0.89
Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol (2003) 0.88
Engineering xylose metabolism in triacylglycerol-producing Rhodococcus opacus for lignocellulosic fuel production. Biotechnol Biofuels (2013) 0.88
Multistep microchemical synthesis enabled by microfluidic distillation. Angew Chem Int Ed Engl (2010) 0.87
Indene bioconversion by a toluene inducible dioxygenase of Rhodococcus sp. I24. Appl Microbiol Biotechnol (2004) 0.87
Superhydrophobic surfaces as smart platforms for the analysis of diluted biological solutions. ACS Appl Mater Interfaces (2012) 0.87
Growth and polyhydroxybutyrate production by Ralstonia eutropha in emulsified plant oil medium. Appl Microbiol Biotechnol (2011) 0.87
Density functional theory study of ligand binding on CdSe (0001), (0001), and (1120) single crystal relaxed and reconstructed surfaces: implications for nanocrystalline growth. J Phys Chem B (2006) 0.87
Flow-through comb electroporation device for delivery of macromolecules. Anal Chem (2013) 0.87
In situ measurement of bioluminescence and fluorescence in an integrated microbioreactor. Biotechnol Bioeng (2006) 0.86
The use of disease-modifying new drugs for multiple sclerosis treatment in private-sector health plans. Clin Ther (2004) 0.86
Sphingomyelinase-induced phase transformations: causing morphology switches and multiple-time-domain ceramide generation in model raft membranes. Langmuir (2010) 0.86
A facile in situ microfluidic method for creating multivalent surfaces: toward functional glycomics. Lab Chip (2012) 0.86
pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus. BMC Microbiol (2004) 0.85
Isopropanol production with engineered Cupriavidus necator as bioproduction platform. Appl Microbiol Biotechnol (2014) 0.85
Oil palm vegetation liquor: a new source of phenolic bioactives. Br J Nutr (2011) 0.85
Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform. Integr Biol (Camb) (2014) 0.84
TraA is required for megaplasmid conjugation in Rhodococcus erythropolis AN12. Plasmid (2006) 0.84
Properties of the CdSe(0001), (0001), and (1120) single crystal surfaces: Relaxation, reconstruction, and adatom and admolecule adsorption. J Phys Chem B (2005) 0.84