Published in Nature on July 27, 2006
Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature (2007) 19.33
Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl (2006) 5.07
Micromechanical control of cell-cell interactions. Proc Natl Acad Sci U S A (2007) 3.53
High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One (2008) 3.34
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity. Proc Natl Acad Sci U S A (2006) 3.15
Biomolecular gradients in cell culture systems. Lab Chip (2007) 2.96
Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging. Proc Natl Acad Sci U S A (2008) 2.88
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Label-free cell separation and sorting in microfluidic systems. Anal Bioanal Chem (2010) 2.60
Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. Bioessays (2008) 2.36
Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells. Proc Natl Acad Sci U S A (2008) 2.22
Fundamentals of microfluidic cell culture in controlled microenvironments. Chem Soc Rev (2010) 2.04
Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron (2010) 2.00
Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov (2015) 1.95
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
Platelet bioreactor-on-a-chip. Blood (2014) 1.87
Nano/Microfluidics for diagnosis of infectious diseases in developing countries. Adv Drug Deliv Rev (2009) 1.87
Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov Today (2007) 1.71
Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol (2011) 1.61
Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc Natl Acad Sci U S A (2010) 1.54
Wrinkled hard skins on polymers created by focused ion beam. Proc Natl Acad Sci U S A (2007) 1.52
Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip (2013) 1.50
Biomimetic tissues on a chip for drug discovery. Drug Discov Today (2011) 1.41
Holographic opto-fluidic microscopy. Opt Express (2010) 1.41
From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integr Biol (Camb) (2009) 1.38
Biology by design: reduction and synthesis of cellular components and behaviour. J R Soc Interface (2007) 1.33
A microfluidic chamber for analysis of neuron-to-cell spread and axonal transport of an alpha-herpesvirus. PLoS One (2008) 1.31
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
Accelerating drug discovery via organs-on-chips. Lab Chip (2013) 1.26
Multi-angle lensless digital holography for depth resolved imaging on a chip. Opt Express (2010) 1.25
Integrating sensing hydrogel microstructures into micropatterned hepatocellular cocultures. Langmuir (2009) 1.24
Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry. Exp Cell Res (2009) 1.23
Cell culture on MEMS platforms: a review. Int J Mol Sci (2009) 1.23
Microfluidic culture models of tumor angiogenesis. Tissue Eng Part A (2010) 1.23
Microfluidics as a functional tool for cell mechanics. Biomicrofluidics (2009) 1.22
Synthetic and bio-artificial tactile sensing: a review. Sensors (Basel) (2013) 1.20
Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. Anal Chem (2009) 1.20
A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices (2009) 1.20
A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res (2010) 1.20
Synthetic microvascular networks for quantitative analysis of particle adhesion. Biomed Microdevices (2008) 1.19
Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization. JALA Charlottesv Va (2010) 1.18
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb) (2013) 1.17
Modelling tissues in 3D: the next future of pharmaco-toxicology and food research? Genes Nutr (2008) 1.16
Characterization of the threshold response of initiation of blood clotting to stimulus patch size. Biophys J (2007) 1.15
Integration of on-chip peristaltic pumps and injection valves with microchip electrophoresis and electrochemical detection. Electrophoresis (2010) 1.11
Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem Soc Rev (2010) 1.10
Integrated acoustic and magnetic separation in microfluidic channels. Appl Phys Lett (2009) 1.10
An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics. Biomicrofluidics (2011) 1.10
Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo. Nat Photonics (2013) 1.10
Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation. Lab Chip (2015) 1.09
Differentially photo-crosslinked polymers enable self-assembling microfluidics. Nat Commun (2011) 1.08
Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci U S A (2012) 1.08
Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget (2014) 1.08
Automated microfluidic protein immunoblotting. Nat Protoc (2010) 1.07
Continuous-flow enzyme assay on a microfluidic chip for monitoring glycerol secretion from cultured adipocytes. Anal Chem (2009) 1.07
Phenotypic variability of growing cellular populations. Proc Natl Acad Sci U S A (2007) 1.07
Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods (2008) 1.07
Emerging technologies for assembly of microscale hydrogels. Adv Healthc Mater (2012) 1.06
Microscale control of cell contact and spacing via three-component surface patterning. Langmuir (2007) 1.06
An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping. Lab Chip (2012) 1.06
Microfluidic technology in vascular research. J Biomed Biotechnol (2009) 1.06
Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl (2011) 1.06
Optofluidic microcavities: Dye-lasers and biosensors. Biomicrofluidics (2010) 1.05
Integration of multiple components in polystyrene-based microfluidic devices part I: fabrication and characterization. Analyst (2012) 1.04
A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification. Lab Chip (2010) 1.04
Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip. Lab Chip (2010) 1.04
In Vitro Electrochemistry of Biological Systems. Annu Rev Anal Chem (Palo Alto Calif) (2008) 1.03
Micropatterned aptasensors for continuous monitoring of cytokine release from human leukocytes. Anal Chem (2011) 1.03
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. Biomicrofluidics (2011) 1.03
Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv (2014) 1.03
Dynamic monitoring of glucagon secretion from living cells on a microfluidic chip. Anal Bioanal Chem (2012) 1.03
Microchip-based integration of cell immobilization, electrophoresis, post-column derivatization, and fluorescence detection for monitoring the release of dopamine from PC 12 cells. Analyst (2008) 1.03
On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem (2010) 1.02
Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip (2010) 1.02
Challenges of drug-resistant malaria. Parasite (2014) 1.02
Measuring enzyme activity in single cells. Trends Biotechnol (2011) 1.01
A microfluidic chip for real-time studies of the volume of single cells. Lab Chip (2008) 1.01
Microfabricated modular scale-down device for regenerative medicine process development. PLoS One (2012) 1.00
Wallerian-like degeneration of central neurons after synchronized and geometrically registered mass axotomy in a three-compartmental microfluidic chip. Neurotox Res (2010) 1.00
Optical oxygen sensors for applications in microfluidic cell culture. Sensors (Basel) (2010) 0.99
Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer Res (2010) 0.98
Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system. Mol Syst Biol (2008) 0.98
Reversibly sealed multilayer microfluidic device for integrated cell perfusion and on-line chemical analysis of cultured adipocyte secretions. Anal Bioanal Chem (2010) 0.97
A microfluidic platform for probing small artery structure and function. Lab Chip (2010) 0.97
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
Breast cancer diagnosis using a microfluidic multiplexed immunohistochemistry platform. PLoS One (2010) 0.97
A prototypic microfluidic platform generating stepwise concentration gradients for real-time study of cell apoptosis. Biomicrofluidics (2010) 0.97
Integrated Microfluidic Reactors. Nano Today (2009) 0.96
Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays. Adv Mater (2013) 0.96
Microfluidic systems for biosensing. Sensors (Basel) (2010) 0.96
Probing cell-cell communication with microfluidic devices. Lab Chip (2013) 0.96
Co-culture systems and technologies: taking synthetic biology to the next level. J R Soc Interface (2014) 0.96
A cost-effective fluorescence mini-microscope for biomedical applications. Lab Chip (2015) 0.95
Continuous analysis of dye-loaded, single cells on a microfluidic chip. Lab Chip (2011) 0.94
Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomed Microdevices (2009) 0.94
Expanding the available assays: adapting and validating In-Cell Westerns in microfluidic devices for cell-based assays. Assay Drug Dev Technol (2010) 0.94
Open access microfluidic device for the study of cell migration during chemotaxis. Integr Biol (Camb) (2010) 0.93
Photolithographic patterning of organosilane monolayer for generating large area two-dimensional B lymphocyte arrays. Lab Chip (2008) 0.92
Integration of multiple components in polystyrene-based microfluidic devices part II: cellular analysis. Analyst (2012) 0.92
A microfluidic platform for studying the effects of small temperature gradients in an incubator environment. Biomicrofluidics (2008) 0.91
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92
Timing and checkpoints in the regulation of mitotic progression. Dev Cell (2004) 5.41
Informatics and quantitative analysis in biological imaging. Science (2003) 5.22
The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol (2005) 5.16
Towards a rigorous assessment of systems biology models: the DREAM3 challenges. PLoS One (2010) 4.94
The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol (2005) 4.81
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (2005) 4.75
Physicochemical modelling of cell signalling pathways. Nat Cell Biol (2006) 4.34
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell (2008) 3.88
Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol (2006) 3.63
The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell (2006) 3.57
Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev (2003) 3.51
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol Syst Biol (2009) 3.50
Structure, function, and regulation of budding yeast kinetochores. Annu Rev Cell Dev Biol (2003) 3.32
Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A (2005) 3.01
Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol (2006) 2.99
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Mol Syst Biol (2009) 2.98
Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol (2008) 2.63
Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol (2004) 2.55
A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A (2013) 2.40
A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J (2005) 2.28
Logic-based models for the analysis of cell signaling networks. Biochemistry (2010) 2.21
A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics (2005) 2.20
Adaptive informatics for multifactorial and high-content biological data. Nat Methods (2011) 2.16
Measuring and modeling apoptosis in single cells. Cell (2011) 2.10
Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol (2009) 2.05
Electronic detection of DNA by its intrinsic molecular charge. Proc Natl Acad Sci U S A (2002) 2.01
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol (2007) 2.00
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99
Microfluidic shear devices for quantitative analysis of cell adhesion. Anal Chem (2004) 1.95
Design and global optimization of high-efficiency thermophotovoltaic systems. Opt Express (2010) 1.91
Classic and contemporary approaches to modeling biochemical reactions. Genes Dev (2010) 1.90
The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. PLoS Comput Biol (2009) 1.88
Crowdsourcing network inference: the DREAM predictive signaling network challenge. Sci Signal (2011) 1.83
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Mol Cell Proteomics (2010) 1.77
An integrated microreactor system for self-optimization of a Heck reaction: from micro- to mesoscale flow systems. Angew Chem Int Ed Engl (2010) 1.77
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure (2006) 1.76
Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat Chem Biol (2013) 1.75
Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. Lab Chip (2006) 1.74
Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol (2009) 1.69
Analysis of kinesin motor function at budding yeast kinetochores. J Cell Biol (2006) 1.67
A microfluidic electroporation device for cell lysis. Lab Chip (2004) 1.66
Transport and reaction in microscale segmented gas-liquid flow. Lab Chip (2004) 1.64
The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J (2006) 1.63
A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics (2003) 1.61
Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol (2004) 1.61
Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol (2006) 1.58
Discovery of potent and selective covalent inhibitors of JNK. Chem Biol (2012) 1.55
Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol Cell (2011) 1.55
Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. PLoS Comput Biol (2011) 1.53
Chromosome segregation and genomic stability. Curr Opin Genet Dev (2004) 1.53
Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A (2005) 1.52
Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis. Angew Chem Int Ed Engl (2011) 1.51
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol (2009) 1.49
S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell (2013) 1.49
Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell (2003) 1.48
Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics (2008) 1.45
Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Res (2011) 1.45
Integrated microreactors for reaction automation: new approaches to reaction development. Annu Rev Anal Chem (Palo Alto Calif) (2010) 1.43
Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. Angew Chem Int Ed Engl (2007) 1.42
Synthesis of micro and nanostructures in microfluidic systems. Chem Soc Rev (2010) 1.40
Micromixing of miscible liquids in segmented gas-liquid flow. Langmuir (2005) 1.36
Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A (2003) 1.36
Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem (2009) 1.34
Flow-induced deformation of shallow microfluidic channels. Lab Chip (2006) 1.34
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem (2012) 1.33
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS One (2007) 1.31
Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol (2012) 1.30
Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol (2012) 1.28
Properties of cell death models calibrated and compared using Bayesian approaches. Mol Syst Biol (2013) 1.28
Microfluidic synthesis of colloidal silica. Langmuir (2004) 1.23
Mps1 at kinetochores is essential for female mouse meiosis I. Development (2011) 1.22
Continuous dielectrophoretic size-based particle sorting. Anal Chem (2006) 1.21
Studying chromosome instability in the mouse. Biochim Biophys Acta (2008) 1.17
Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res (2010) 1.16
Programming biological models in Python using PySB. Mol Syst Biol (2013) 1.15
End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation. Angew Chem Int Ed Engl (2013) 1.15
Microchemical systems for continuous-flow synthesis. Lab Chip (2009) 1.14
Microfluidics-based assessment of cell deformability. Anal Chem (2012) 1.13
p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell (2011) 1.12
Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS One (2009) 1.11
Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). Bioinformatics (2013) 1.09
Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem (2005) 1.09
Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip (2005) 1.09
A microfabricated device for subcellular organelle sorting. Anal Chem (2004) 1.09
Microfluidic based single cell microinjection. Lab Chip (2008) 1.08
Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng (2004) 1.08
Integrated continuous microfluidic liquid-liquid extraction. Lab Chip (2006) 1.07
Reactive polymer coatings: a first step toward surface engineering of microfluidic devices. Anal Chem (2003) 1.06
Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip (2006) 1.06
Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions. Angew Chem Int Ed Engl (2007) 1.06
Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Mol Biosyst (2010) 1.04
A microfabricated gas-liquid segmented flow reactor for high-temperature synthesis: the case of CdSe quantum dots. Angew Chem Int Ed Engl (2005) 1.03
Toward high-energy-density, high-efficiency, and moderate-temperature chip-scale thermophotovoltaics. Proc Natl Acad Sci U S A (2013) 1.01
Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol Syst Biol (2011) 0.99
Investigation of indium phosphide nanocrystal synthesis using a high-temperature and high-pressure continuous flow microreactor. Angew Chem Int Ed Engl (2010) 0.98
Micro free-flow IEF enhanced by active cooling and functionalized gels. Electrophoresis (2006) 0.98