Published in Biochemistry on February 08, 2005
Bacterial polymers: biosynthesis, modifications and applications. Nat Rev Microbiol (2010) 1.75
Molecular characterization of the phaECHm genes, required for biosynthesis of poly(3-hydroxybutyrate) in the extremely halophilic archaeon Haloarcula marismortui. Appl Environ Microbiol (2007) 1.24
Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol (2005) 1.24
Localization of poly(3-hydroxybutyrate) (PHB) granule-associated proteins during PHB granule formation and identification of two new phasins, PhaP6 and PhaP7, in Ralstonia eutropha H16. J Bacteriol (2012) 1.08
Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases. ACS Chem Biol (2014) 0.88
Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase. Biochemistry (2009) 0.84
Chemistry with an artificial primer of polyhydroxybutyrate synthase suggests a mechanism for chain termination. Biochemistry (2015) 0.79
Trapping of intermediates with substrate analog HBOCoA in the polymerizations catalyzed by class III polyhydroxybutyrate (PHB) synthase from Allochromatium vinosum. ACS Chem Biol (2015) 0.78
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. J Biol Chem (2016) 0.77
Study of Class I and Class III Polyhydroxyalkanoate (PHA) Synthases with Substrates Containing a Modified Side Chain. Biomacromolecules (2016) 0.75
Structure of polyhydroxyalkanoate (PHA) synthase PhaC from Chromobacterium sp. USM2, producing biodegradable plastics. Sci Rep (2017) 0.75
Bleomycins: towards better therapeutics. Nat Rev Cancer (2005) 2.52
The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nat Struct Biol (2002) 2.28
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A (2003) 2.24
Structural basis for activation of class Ib ribonucleotide reductase. Science (2010) 2.07
Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology. Philos Trans R Soc Lond B Biol Sci (2006) 1.94
Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase. Biochemistry (2003) 1.68
Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Proc Natl Acad Sci U S A (2007) 1.63
The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production. J Bacteriol (2002) 1.60
pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway. J Am Chem Soc (2006) 1.57
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J Am Chem Soc (2007) 1.54
Ralstonia eutropha H16 encodes two and possibly three intracellular Poly[D-(-)-3-hydroxybutyrate] depolymerase genes. J Bacteriol (2003) 1.46
Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. Annu Rev Biochem (2005) 1.45
Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A (2003) 1.36
Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry (2003) 1.32
Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS Genet (2011) 1.30
YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase. Biochemistry (2007) 1.30
Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol (2005) 1.24
NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proc Natl Acad Sci U S A (2008) 1.23
Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate. Biochemistry (2009) 1.18
Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression. J Bacteriol (2010) 1.18
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A (2006) 1.17
PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. J Am Chem Soc (2007) 1.17
High-cell-density batch fermentation of Rhodococcus opacus PD630 using a high glucose concentration for triacylglycerol production. J Biotechnol (2010) 1.15
2,3-difluorotyrosine at position 356 of ribonucleotide reductase R2: a probe of long-range proton-coupled electron transfer. J Am Chem Soc (2003) 1.15
A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics (2006) 1.15
Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip (2006) 1.15
Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture. Lab Chip (2011) 1.14
Analysis of transient polyhydroxybutyrate production in Wautersia eutropha H16 by quantitative Western analysis and transmission electron microscopy. J Bacteriol (2005) 1.14
Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. Biochemistry (2004) 1.13
A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. J Am Chem Soc (2010) 1.12
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry (2005) 1.10
Electron transfer reactions of fluorotyrosyl radicals. J Am Chem Soc (2006) 1.10
Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16. J Bacteriol (2010) 1.09
Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. J Am Chem Soc (2007) 1.09
Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases. J Am Chem Soc (2011) 1.09
Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip (2005) 1.09
Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol (2013) 1.08
Chris Raetz, scientist and enduring friend. Proc Natl Acad Sci U S A (2011) 1.08
Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng (2004) 1.08
Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase. J Am Chem Soc (2007) 1.07
Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip (2006) 1.06
Turning on ribonucleotide reductase by light-initiated amino acid radical generation. Proc Natl Acad Sci U S A (2004) 1.06
Synthesis and characterization of oligonucleotides containing a 4'-keto abasic site. Biochemistry (2004) 1.05
Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage. Nucleic Acids Res (2008) 1.05
Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. Biochemistry (2009) 1.04
Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry (2008) 1.04
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. J Biol Chem (2011) 1.03
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry (2004) 1.02
Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation. Appl Microbiol Biotechnol (2005) 1.01
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry (2006) 1.01
Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil by engineered Ralstonia eutropha strains. Appl Environ Microbiol (2011) 1.01
Rhodostreptomycins, antibiotics biosynthesized following horizontal gene transfer from Streptomyces padanus to Rhodococcus fascians. J Am Chem Soc (2008) 1.00
Whole-genome microarray and gene deletion studies reveal regulation of the polyhydroxyalkanoate production cycle by the stringent response in Ralstonia eutropha H16. Appl Environ Microbiol (2012) 1.00
Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. J Am Chem Soc (2005) 0.99
Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med (2003) 0.99
Potential of Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol. Appl Microbiol Biotechnol (2006) 0.99
Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. Biochemistry (2012) 0.98
Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. J Am Chem Soc (2011) 0.98
Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy. J Am Chem Soc (2009) 0.98
Studies on the production of branched-chain alcohols in engineered Ralstonia eutropha. Appl Microbiol Biotechnol (2012) 0.97
Growth and localization of polyhydroxybutyrate granules in Ralstonia eutropha. J Bacteriol (2011) 0.96
Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation. Nucleic Acids Res (2002) 0.95
GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chem Res Toxicol (2007) 0.95
In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. Biomacromolecules (2005) 0.95
Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase. Biochemistry (2009) 0.94
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry (2006) 0.94
Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. J Biol Chem (2012) 0.94
Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. J Am Chem Soc (2013) 0.94
Methodology to probe subunit interactions in ribonucleotide reductases. Biochemistry (2008) 0.94
ENDOR spectroscopy and DFT calculations: evidence for the hydrogen-bond network within α2 in the PCET of E. coli ribonucleotide reductase. J Am Chem Soc (2012) 0.93
Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: a mechanistic probe for a redox-active tyrosine. J Am Chem Soc (2004) 0.93
Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. Chem Rev (1998) 0.93
Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger. Proc Natl Acad Sci U S A (2011) 0.93
Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase. Biochemistry (2009) 0.91
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. J Am Chem Soc (2013) 0.91
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry (2004) 0.91
Engineered Corynebacterium glutamicum as an endotoxin-free platform strain for lactate-based polyester production. Appl Microbiol Biotechnol (2011) 0.91
Gene expression analysis of Escherichia coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data. Appl Microbiol Biotechnol (2005) 0.91
Characterization of the highly active polyhydroxyalkanoate synthase of Chromobacterium sp. strain USM2. Appl Environ Microbiol (2011) 0.91
Pulsed ELDOR spectroscopy measures the distance between the two tyrosyl dadicals in the R2 subunit of the E. coli ribonucleotide reductase. J Am Chem Soc (2003) 0.91
Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. Biochemistry (2005) 0.90
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry (2007) 0.90
Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites. Biochemistry (2007) 0.89
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry (2004) 0.89
Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol (2003) 0.88
Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases. ACS Chem Biol (2014) 0.88
Engineering xylose metabolism in triacylglycerol-producing Rhodococcus opacus for lignocellulosic fuel production. Biotechnol Biofuels (2013) 0.88
Growth and polyhydroxybutyrate production by Ralstonia eutropha in emulsified plant oil medium. Appl Microbiol Biotechnol (2011) 0.87
Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chem Biol (2012) 0.87
Indene bioconversion by a toluene inducible dioxygenase of Rhodococcus sp. I24. Appl Microbiol Biotechnol (2004) 0.87
Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. Biochemistry (2003) 0.87
Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A (2014) 0.86
In situ measurement of bioluminescence and fluorescence in an integrated microbioreactor. Biotechnol Bioeng (2006) 0.86
The use of disease-modifying new drugs for multiple sclerosis treatment in private-sector health plans. Clin Ther (2004) 0.86
Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer. Biochemistry (2013) 0.85