Published in Nat Med on July 02, 2006
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell (2009) 3.03
Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev (2009) 1.90
Thresholds for thermal damage to normal tissues: an update. Int J Hyperthermia (2011) 1.86
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc Natl Acad Sci U S A (2009) 1.85
Fever, febrile seizures and epilepsy. Trends Neurosci (2007) 1.67
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A (2007) 1.45
Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. J Neurosci (2013) 1.41
Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant. Epilepsia (2010) 1.31
Detecting activity-evoked pH changes in human brain. Proc Natl Acad Sci U S A (2012) 1.11
Upregulated H-current in hyperexcitable CA1 dendrites after febrile seizures. Front Cell Neurosci (2008) 1.06
High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus. Front Cell Neurosci (2012) 1.06
Animal models of epilepsy: use and limitations. Neuropsychiatr Dis Treat (2014) 1.04
Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus. Neurotherapeutics (2014) 1.03
Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. J Neurosci (2012) 1.00
Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr (2011) 0.95
Multiple molecular mechanisms for a single GABAA mutation in epilepsy. Neurology (2013) 0.95
Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions? J Physiol (2012) 0.93
Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J (2013) 0.89
Pursuing paradoxical proconvulsant prophylaxis for epileptogenesis. Epilepsia (2009) 0.89
I(h)-mediated depolarization enhances the temporal precision of neuronal integration. Nat Commun (2011) 0.89
Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility. J Physiol (2012) 0.88
Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance. Epilepsia (2012) 0.84
Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus. PLoS One (2015) 0.82
Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia. Br J Pharmacol (2010) 0.82
Na(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies. Front Physiol (2013) 0.80
Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia. Brain (2012) 0.80
Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5. Front Physiol (2014) 0.80
Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy. Cereb Cortex (2016) 0.79
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling. Sci Rep (2016) 0.79
Na⁺/H⁺ exchangers and intracellular pH in perinatal brain injury. Transl Stroke Res (2014) 0.79
A valuable and promising method for recording brain activity in behaving newborn rodents. Dev Psychobiol (2015) 0.79
Identification of Srp9 as a febrile seizure susceptibility gene. Ann Clin Transl Neurol (2014) 0.78
Neuronal injury and cytogenesis after simple febrile seizures in the hippocampal dentate gyrus of juvenile rat. Childs Nerv Syst (2012) 0.77
Emerging roles of Na(+)/H(+) exchangers in epilepsy and developmental brain disorders. Prog Neurobiol (2016) 0.77
Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro. Br J Pharmacol (2009) 0.76
Generation of Febrile Seizures and Subsequent Epileptogenesis. Neurosci Bull (2016) 0.76
Towards bridging the gap between acid-base transporters and neuronal excitability modulation. Int J Physiol Pathophysiol Pharmacol (2014) 0.75
Cortical Temperature Change: A Tool for Modulating Brain States? eNeuro (2016) 0.75
Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation. Front Cell Neurosci (2016) 0.75
Copeptin as a serum biomarker of febrile seizures. PLoS One (2015) 0.75
CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study. J Transl Med (2013) 0.75
Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures. EBioMedicine (2017) 0.75
Arresting a seizure by dropping a little Acid. Epilepsy Curr (2009) 0.75
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations. Physiol Rep (2017) 0.75
Putting the heat on febrile seizures. Nat Med (2006) 0.75
Forebrain-independent generation of hyperthermic convulsions in infant rats. Epilepsia (2015) 0.75
Pyramidal Neuron Axon Initial Segment Dysregulation in Nav β1 Subunit Epilepsy: A Tip of the Iceberg. Epilepsy Curr (2011) 0.75
Respiratory alkalosis: "basic" mechanism of febrile seizures? Epilepsy Curr (2007) 0.75
Stopping seizures with carbon dioxide. Epilepsy Curr (2011) 0.75
Regulation and modulation of pH in the brain. Physiol Rev (2003) 4.04
Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med (2001) 3.44
Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol (1993) 3.41
Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci (2004) 3.23
Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat Med (1999) 3.18
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur J Neurosci (2000) 2.69
Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci (2002) 2.65
The prevalence and incidence of convulsive disorders in children. Epilepsia (1994) 2.65
Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol (2000) 2.55
Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain (2006) 2.44
Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol (2004) 2.41
Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J Neurosci (1998) 1.95
Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome. Ann Neurol (1999) 1.91
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron (2003) 1.80
Establishing clinically relevant standards for tachypnea in febrile children younger than 2 years. Arch Pediatr Adolesc Med (1995) 1.70
Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res Dev Brain Res (1997) 1.60
Susceptibility of immature and adult brains to seizure effects. Lancet Neurol (2004) 1.55
Complex febrile seizures. Epilepsia (1996) 1.53
The effect of temperature reduction on respiratory rate in febrile illnesses. Arch Dis Child (1993) 1.46
Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci (2006) 1.45
Epidemiology of febrile and afebrile convulsions in children in Japan. Neurology (1984) 1.42
Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. J Physiol (1988) 1.38
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate. Neurosci Lett (1987) 1.36
Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions. Ann Neurol (1987) 1.34
Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. Proc Natl Acad Sci U S A (2005) 1.32
Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci (2003) 1.30
Activity-dependent intracellular acidification correlates with the duration of seizure activity. J Neurosci (2000) 1.26
Fever, genes, and epilepsy. Lancet Neurol (2004) 1.24
Protons trap NR1/NR2B NMDA receptors in a nonconducting state. J Neurosci (2005) 1.21
Activity-dependent pH shifts and periodic recurrence of spontaneous interictal spikes in a model of focal epileptogenesis. J Neurosci (1998) 1.21
Susceptibility genes for complex epilepsy. Hum Mol Genet (2005) 1.17
Neonatal maturation of the hypercapnic ventilatory response and central neural CO2 chemosensitivity. Respir Physiol Neurobiol (2005) 1.16
Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator. J Neurophysiol (2002) 1.14
Interstitial PCO2 and pH in rat hippocampal slices measured by means of a novel fast CO2/H(+)-sensitive microelectrode based on a PVC-gelled membrane. Pflugers Arch (1993) 1.12
Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons. J Gen Physiol (2003) 1.06
The sensitivity of liquid sensor, ion-selective microelectrodes to changes in temperature and solution level. Pflugers Arch (1986) 1.05
Effect of CO2 on the metabolic and ventilatory responses to ambient temperature in conscious adult and newborn rats. J Physiol (1996) 1.03
Effects of CO2 on excitatory transmission apparently caused by changes in intracellular pH in the rat hippocampal slice. Brain Res (1996) 1.03
Febrile seizures and mechanisms of epileptogenesis: insights from an animal model. Adv Exp Med Biol (2004) 1.02
Postnatal development of rat hippocampal gamma rhythm in vivo. J Neurophysiol (2002) 1.02
Correcting respiratory rate for the presence of fever. J Clin Epidemiol (1994) 1.00
Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children. Science (1981) 0.97
Ventilatory responses to changes in temperature in mammals and other vertebrates. Annu Rev Physiol (2000) 0.97
Activity dependent alkaline and acid transients in guinea pig hippocampal slices. Brain Res (1989) 0.95
Direct cooling of the human brain by heat loss from the upper respiratory tract. J Appl Physiol (1985) (1999) 0.95
Will a critical level of hyperventilation-induced hypocapnia always induce an absence seizure? Epilepsia (1996) 0.91
Variability of the breathing pattern in newborn rats: effects of ambient temperature in normoxia or hypoxia. Pediatr Res (2000) 0.90
Full-band EEG (fbEEG): a new standard for clinical electroencephalography. Clin EEG Neurosci (2005) 0.84
The suppression of formalin-induced fos expression by different anesthetic agents in the infant rat. Dev Psychobiol (1996) 0.82
Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (2005) 5.12
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 4.80
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron (2006) 4.12
Cation-chloride cotransporters and neuronal function. Neuron (2009) 3.95
Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci (2003) 3.87
Phase synchrony among neuronal oscillations in the human cortex. J Neurosci (2005) 3.41
Synaptic plasticity at hippocampal mossy fibre synapses. Nat Rev Neurosci (2005) 3.26
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. J Gen Physiol (2005) 2.98
Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci (2003) 2.84
Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci (2006) 2.81
Very slow EEG fluctuations predict the dynamics of stimulus detection and oscillation amplitudes in humans. J Neurosci (2008) 2.80
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci (2007) 2.79
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76
CB2: a cannabinoid receptor with an identity crisis. Br J Pharmacol (2010) 2.74
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci U S A (2008) 2.42
Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron (2007) 2.37
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature (2012) 2.36
Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types. J Neurosci (2005) 2.32
Does hyperventilation elicit epileptic seizures? Epilepsia (2004) 2.26
Inhibition and brain work. Neuron (2007) 2.22
Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science (2007) 2.21
Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis. J Cell Biol (2009) 2.21
The cellular, molecular and ionic basis of GABA(A) receptor signalling. Prog Brain Res (2007) 2.19
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation (2004) 2.15
GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci (2008) 2.14
A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am J Hum Genet (2007) 2.13
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11
Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. J Physiol (2005) 2.06
Clinical efficacy and safety of an implantable cardioverter-defibrillator lead with a floating atrial sensing dipole. Pacing Clin Electrophysiol (2013) 2.02
Spatial spectra of scalp EEG and EMG from awake humans. Clin Neurophysiol (2003) 1.95
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids. Neuron (2007) 1.85
Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq. J Gen Physiol (2004) 1.82
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron (2003) 1.80
JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. Br J Pharmacol (2010) 1.79
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol (2007) 1.77
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci (2009) 1.73
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem (2006) 1.71
The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci (2007) 1.68
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol (2005) 1.66
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A (2009) 1.63
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol (2007) 1.63
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc Natl Acad Sci U S A (2005) 1.62
Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain (2006) 1.61
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science (2011) 1.59
Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. J Biol Chem (2003) 1.58
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? Mol Pharmacol (2005) 1.55
Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus. J Neurosci (2005) 1.52
Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science (2002) 1.51
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. BMC Genomics (2011) 1.49
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology (2015) 1.48
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A (2008) 1.47
Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis. Rev Neurosci (2002) 1.46
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Mol Pharmacol (2009) 1.46
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A (2007) 1.45
Development of neonatal EEG activity: from phenomenology to physiology. Semin Fetal Neonatal Med (2006) 1.42
Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids. J Neurosci (2002) 1.41
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J (2009) 1.41
Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J Neurosci (2007) 1.40
Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci (2002) 1.37
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J Neurosci (2011) 1.37
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. J Physiol (2010) 1.36
Fine spatiotemporal structure of phase in human intracranial EEG. Clin Neurophysiol (2006) 1.36
Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. J Neurosci (2009) 1.34
Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels. Br J Pharmacol (2002) 1.34
Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission. Eur J Neurosci (2003) 1.33
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A (2005) 1.33
Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. Am J Physiol Gastrointest Liver Physiol (2003) 1.32
Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology (2007) 1.31
Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant. Epilepsia (2010) 1.31
Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus. J Comp Neurol (2002) 1.31
Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example. Chem Phys Lipids (2002) 1.30
Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus. Glia (2012) 1.29
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. Neuropsychopharmacology (2009) 1.29
A molecular basis of analgesic tolerance to cannabinoids. J Neurosci (2007) 1.28
A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation. J Neurosci Methods (2003) 1.28
Single-trial phase precession in the hippocampus. J Neurosci (2009) 1.27
A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem (2007) 1.26