The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.

PubWeight™: 1.36‹?› | Rank: Top 10%

🔗 View Article (PMC 2876807)

Published in J Physiol on March 08, 2010

Authors

Tero Viitanen1, Eva Ruusuvuori, Kai Kaila, Juha Voipio

Author Affiliations

1: Department of Biosciences, PO Box 65, FI-00014 University of Helsinki, Helsinki, Finland.

Articles citing this

Mechanisms of physiological and epileptic HFO generation. Prog Neurobiol (2012) 1.64

Cation-chloride cotransporters in neuronal development, plasticity and disease. Nat Rev Neurosci (2014) 1.50

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity. Prog Neurobiol (2011) 1.41

Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant. Epilepsia (2010) 1.31

State-dependent function of neocortical chandelier cells. J Neurosci (2011) 1.18

Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges. J Neurosci (2014) 1.11

Spatial and temporal dynamics in the ionic driving force for GABA(A) receptors. Neural Plast (2011) 1.01

Short-term ionic plasticity at GABAergic synapses. Front Synaptic Neurosci (2012) 0.99

Tonic inhibition sets the state of excitability in olfactory bulb granule cells. J Physiol (2013) 0.97

GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci (2012) 0.96

Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions. Front Comput Neurosci (2013) 0.95

Astrocytic and neuronal accumulation of elevated extracellular K(+) with a 2/3 K(+)/Na(+) flux ratio-consequences for energy metabolism, osmolarity and higher brain function. Front Comput Neurosci (2013) 0.93

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions? J Physiol (2012) 0.93

Altered GABA signaling in early life epilepsies. Neural Plast (2011) 0.92

Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures. Epilepsia (2012) 0.91

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J (2013) 0.89

Bicarbonate efflux via GABA(A) receptors depolarizes membrane potential and inhibits two-pore domain potassium channels of astrocytes in rat hippocampal slices. Glia (2012) 0.89

The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide. Epilepsia (2012) 0.88

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine. Neuropsychopharmacology (2015) 0.88

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia (2014) 0.87

Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action. J Pain (2014) 0.85

Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur J Neurosci (2013) 0.84

Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy. Epilepsy Res (2014) 0.83

Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci (2015) 0.82

KCC2 function modulates in vitro ictogenesis. Neurobiol Dis (2015) 0.81

Ion dynamics during seizures. Front Cell Neurosci (2015) 0.80

Adenosine and seizure termination: endogenous mechanisms. Epilepsy Curr (2013) 0.80

Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol (2013) 0.80

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. Neurobiol Dis (2015) 0.79

Limbic networks and epileptiform synchronization: the view from the experimental side. Int Rev Neurobiol (2014) 0.79

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro. Neuroscience (2012) 0.79

GABAergic networks jump-start focal seizures. Epilepsia (2016) 0.79

Ventral tegmental area GABA neurons and opiate motivation. Psychopharmacology (Berl) (2013) 0.79

Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy. J Neurophysiol (2016) 0.78

Neuronal and astroglial correlates underlying spatiotemporal intrinsic optical signal in the rat hippocampal slice. PLoS One (2013) 0.78

Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One (2012) 0.78

Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice. Nat Commun (2015) 0.78

STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. PLoS One (2013) 0.77

Emerging roles of Na(+)/H(+) exchangers in epilepsy and developmental brain disorders. Prog Neurobiol (2016) 0.77

Activation of specific neuronal networks leads to different seizure onset types. Ann Neurol (2016) 0.77

Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition. Neurobiol Dis (2015) 0.76

Carbonic anhydrase inhibition by acetazolamide reduces in vitro epileptiform synchronization. Neuropharmacology (2015) 0.76

Models of drug-induced epileptiform synchronization in vitro. J Neurosci Methods (2015) 0.76

Optogenetic study of networks in epilepsy. J Neurosci Res (2016) 0.76

On the contribution of KCC2 and carbonic anhydrase to two types of in vitro interictal discharge. Pflugers Arch (2015) 0.75

Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission. Front Cell Neurosci (2015) 0.75

Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina. BMC Neurol (2016) 0.75

Blockade of in vitro ictogenesis by low-frequency stimulation coincides with increased epileptiform response latency. J Neurophysiol (2015) 0.75

Initiation, Propagation, and Termination of Partial (Focal) Seizures. Cold Spring Harb Perspect Med (2015) 0.75

Circadian Plasticity of Mammalian Inhibitory Interneurons. Neural Plast (2017) 0.75

Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex. Sci Rep (2017) 0.75

Synaptic conversion of chloride-dependent synapses in spinal nociceptive circuits: roles in neuropathic pain. Pain Res Treat (2011) 0.75

Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria. PLoS One (2016) 0.75

The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Front Cell Neurosci (2017) 0.75

Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization. Neurobiol Dis (2017) 0.75

Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors. Psychopharmacology (Berl) (2017) 0.75

Articles cited by this

Intracellular pH. Physiol Rev (1981) 16.27

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry (1979) 11.28

Reporting ethical matters in the Journal of Physiology: standards and advice. J Physiol (2009) 10.92

Excitatory actions of gaba during development: the nature of the nurture. Nat Rev Neurosci (2002) 8.74

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature (1999) 7.66

Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol (1987) 7.23

On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science (2002) 5.87

Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science (1995) 4.12

Regulation and modulation of pH in the brain. Physiol Rev (2003) 4.04

Cation-chloride cotransporters and neuronal function. Neuron (2009) 3.95

Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci (2003) 3.87

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci (2007) 2.79

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron (2001) 2.71

Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci (2007) 2.44

Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J Biol Chem (1996) 2.41

Ionic basis of GABAA receptor channel function in the nervous system. Prog Neurobiol (1994) 2.41

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40

Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro. J Physiol (1982) 2.39

Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Prog Neurobiol (2002) 2.29

Inhibition and brain work. Neuron (2007) 2.22

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci (2008) 2.14

Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11

Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Am J Physiol (1997) 2.10

Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. J Neurophysiol (1989) 1.98

Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol (1996) 1.88

Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature (1987) 1.87

Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol (2005) 1.74

Activity-dependent disinhibition. II. Effects of extracellular potassium, furosemide, and membrane potential on ECl- in hippocampal CA3 neurons. J Neurophysiol (1989) 1.73

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proc Natl Acad Sci U S A (2006) 1.71

Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol (1999) 1.71

Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. J Neurosci (1996) 1.68

Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons. J Neurosci (2000) 1.67

Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient. J Neurosci (1997) 1.62

Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function. Neuron (2005) 1.60

Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration. Exp Brain Res (1980) 1.59

Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Neuron (1996) 1.56

Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue. Adv Neurol (1986) 1.50

Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy. Epilepsy Res (2006) 1.45

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J (2003) 1.42

Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science (1995) 1.34

A furosemide-sensitive K+-Cl- cotransporter counteracts intracellular Cl- accumulation and depletion in cultured rat midbrain neurons. J Neurosci (1999) 1.33

Relative contributions of passive equilibrium and active transport to the distribution of chloride in mammalian cortical neurons. J Neurophysiol (1988) 1.32

Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol (1995) 1.30

Potassium dynamics in the epileptic cortex: new insights on an old topic. Neuroscientist (2008) 1.29

THE HIPPOCAMPUS. Physiol Rev (1964) 1.21

Furosemide and mannitol suppression of epileptic activity in the human brain. J Neurophysiol (2005) 1.20

Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. J Physiol (2002) 1.20

Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms? Biol Cell (2003) 1.18

Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres. J Physiol (1989) 1.14

GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex. Brain (2004) 1.14

Interstitial PCO2 and pH in rat hippocampal slices measured by means of a novel fast CO2/H(+)-sensitive microelectrode based on a PVC-gelled membrane. Pflugers Arch (1993) 1.12

Cellular factors influencing GABA response in hippocampal pyramidal cells. J Neurophysiol (1982) 1.09

Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. II. Role of extracellular potassium. J Neurophysiol (1986) 1.09

Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells. J Neurosci (2004) 1.08

Design-based estimation of neuronal number and individual neuronal volume in the rat hippocampus. J Neurosci Methods (2007) 1.07

GABAergic excitation and K(+)-mediated volume transmission in the hippocampus. Prog Brain Res (2000) 1.04

Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus. J Neurophysiol (1993) 1.03

Pharmacological isolation of the synaptic and nonsynaptic components of the GABA-mediated biphasic response in rat CA1 hippocampal pyramidal cells. J Neurosci (1999) 1.01

Excitatory effects and electroencephalographic correlation of etomidate, thiopental, methohexital, and propofol. Anesth Analg (1993) 1.00

Cellular and network mechanisms of electrographic seizures. Drug Discov Today Dis Models (2008) 0.96

Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine. J Neurophysiol (1997) 0.96

Furosemide reveals heterogeneous GABA(A) receptor expression at adult rat Golgi cell to granule cell synapses. Neuropharmacology (2002) 0.96

Anticonvulsant actions of furosemide in vitro. Neuroscience (1999) 0.96

Potassium accumulation in interstitial space during epileptiform seizures. Exp Neurol (1970) 0.94

Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy. Brain Res (2002) 0.93

Application of the physical disector to the central nervous system: estimation of the total number of neurons in subdivisions of the rat hippocampus. Anat Sci Int (2005) 0.91

Chloride-cotransport blockade desynchronizes neuronal discharge in the "epileptic" hippocampal slice. J Neurophysiol (2000) 0.90

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem (2008) 0.89

Swelling and potassium uptake in cultured astrocytes. Can J Physiol Pharmacol (1987) 0.88

Carbonic anhydrase inhibitors as anticonvulsant agents. Curr Top Med Chem (2007) 0.86

Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice. Exp Brain Res (1991) 0.86

Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro. J Neurophysiol (2001) 0.83

Furosemide terminates limbic status epilepticus in freely moving rats. Epilepsia (2003) 0.81

A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. Neuroscience (2004) 0.77

Articles by these authors

Cation-chloride cotransporters and neuronal function. Neuron (2009) 3.95

Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci (2003) 3.87

Phase synchrony among neuronal oscillations in the human cortex. J Neurosci (2005) 3.41

Very slow EEG fluctuations predict the dynamics of stimulus detection and oscillation amplitudes in humans. J Neurosci (2008) 2.80

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci (2007) 2.79

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40

KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron (2007) 2.37

Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nat Med (2006) 2.34

Inhibition and brain work. Neuron (2007) 2.22

The cellular, molecular and ionic basis of GABA(A) receptor signalling. Prog Brain Res (2007) 2.19

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci (2008) 2.14

Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11

Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci (2009) 1.73

Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus. J Neurosci (2005) 1.52

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A (2007) 1.45

Development of neonatal EEG activity: from phenomenology to physiology. Semin Fetal Neonatal Med (2006) 1.42

Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission. Eur J Neurosci (2003) 1.33

Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant. Epilepsia (2010) 1.31

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus. Glia (2012) 1.29

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem (2007) 1.26

Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development. Eur J Neurosci (2002) 1.26

Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex. Eur J Neurosci (2005) 1.25

The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus. J Physiol (2006) 1.24

Development of hemodynamic responses and functional connectivity in rat somatosensory cortex. Nat Neurosci (2007) 1.23

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices. Eur J Neurosci (2005) 1.23

Stimulus-induced change in long-range temporal correlations and scaling behaviour of sensorimotor oscillations. Eur J Neurosci (2004) 1.22

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments. Neuropharmacology (2012) 1.18

Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy. Ann Neurol (2011) 1.16

Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator. J Neurophysiol (2002) 1.14

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain (2009) 1.12

A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. J Neurosci (2010) 1.09

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. J Neurosci (2012) 1.08

Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells. J Neurosci (2004) 1.08

Full-band EEG (FbEEG): an emerging standard in electroencephalography. Clin Neurophysiol (2005) 1.07

Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism. J Neurosci (2010) 1.07

Vagal nerve stimulation induces intermittent hypocapnia. Epilepsia (2003) 1.07

Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci (2008) 1.04

Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. J Neurosci (2003) 1.04

Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+ -activated K+ current. Eur J Neurosci (2006) 1.03

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci (2010) 1.02

Postnatal development of rat hippocampal gamma rhythm in vivo. J Neurophysiol (2002) 1.02

Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses. Glia (2014) 1.00

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. J Neurosci (2012) 1.00

An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo. Cereb Cortex (2012) 0.98

Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J Neurochem (2009) 0.95

Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium. J Neurosci (2003) 0.94

Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse. Endocrinology (2003) 0.93

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions? J Physiol (2012) 0.93

Respiratory alkalosis in children with febrile seizures. Epilepsia (2011) 0.93

GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus. J Neurosci (2004) 0.92

Distinct gamma-band evoked responses to speech and non-speech sounds in humans. J Neurosci (2002) 0.90

Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists. Neuropharmacology (2002) 0.90

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett (2005) 0.89

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J (2013) 0.89

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia (2014) 0.87

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. Ann Neurol (2014) 0.85

Neurobiological and physiological mechanisms of fever-related epileptiform syndromes. Brain Dev (2009) 0.85

Carbonic anhydrases and brain pH in the control of neuronal excitability. Subcell Biochem (2014) 0.85

Full-band EEG (fbEEG): a new standard for clinical electroencephalography. Clin EEG Neurosci (2005) 0.84

Preterm EEG: a multimodal neurophysiological protocol. J Vis Exp (2012) 0.82

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem (2010) 0.82

Nonneuronal origin of CO2-related DC EEG shifts: an in vivo study in the cat. J Neurophysiol (2004) 0.82

Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain (2012) 0.80

Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia. Brain (2012) 0.80

GABAergic control of CA3-driven network events in the developing hippocampus. Results Probl Cell Differ (2008) 0.80

Pronounced increase in breathing rate in the "hair dryer model" of experimental febrile seizures. Epilepsia (2008) 0.80

Visually evoked gamma responses in the human brain are enhanced during voluntary hyperventilation. Neuroimage (2002) 0.78

GAT-1 acts to limit a tonic GABA(A) current in rat CA3 pyramidal neurons at birth. Eur J Neurosci (2007) 0.78