Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.

PubWeight™: 5.14‹?› | Rank: Top 1%

🔗 View Article (PMID 1682054)

Published in Cell on November 01, 1991

Authors

C Wolberger1, A K Vershon, B Liu, A D Johnson, C O Pabo

Author Affiliations

1: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.

Articles citing this

(truncated to the top 100)

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J (1992) 4.73

A knotted1-like homeobox gene in Arabidopsis is expressed in the vegetative meristem and dramatically alters leaf morphology when overexpressed in transgenic plants. Plant Cell (1994) 4.58

Origins of specificity in protein-DNA recognition. Annu Rev Biochem (2010) 4.43

Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell (2008) 3.96

DNA bending: the prevalence of kinkiness and the virtues of normality. Nucleic Acids Res (1998) 3.67

Mutational analysis of the integrase protein of human immunodeficiency virus type 2. Proc Natl Acad Sci U S A (1992) 3.55

Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell (2007) 3.34

Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acids Res (1997) 3.26

Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A (1993) 3.11

HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily. Proc Natl Acad Sci U S A (1992) 2.94

Chimeric restriction endonuclease. Proc Natl Acad Sci U S A (1994) 2.64

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev (1999) 2.54

DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J (1994) 2.48

Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol (1996) 2.48

The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J (1992) 2.36

Sequence analysis and expression patterns divide the maize knotted1-like homeobox genes into two classes. Plant Cell (1994) 2.33

The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J (1994) 2.33

DNA-binding specificity of Mcm1: operator mutations that alter DNA-bending and transcriptional activities by a MADS box protein. Mol Cell Biol (1997) 2.33

Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol (1996) 2.32

Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J (1992) 2.32

Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. EMBO J (1992) 2.26

Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol Cell Biol (1995) 2.11

Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol Cell Biol (1992) 2.11

Compilation of sequence-specific DNA-binding proteins implicated in transcriptional control in fungi. Nucleic Acids Res (1993) 1.98

The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol Cell Biol (1995) 1.93

DNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families. Proc Natl Acad Sci U S A (1994) 1.90

The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of different DNA binding specificities. EMBO J (1993) 1.85

Structural studies of the engrailed homeodomain. Protein Sci (1994) 1.85

Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80

Identification of a meristem L1 layer-specific gene in Arabidopsis that is expressed during embryonic pattern formation and defines a new class of homeobox genes. Plant Cell (1996) 1.76

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol Cell Biol (1995) 1.76

The control of trunk Hox specificity and activity by Extradenticle. Genes Dev (1999) 1.75

N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65. Mol Cell Biol (1993) 1.75

Characterization of the transcription activation function and the DNA binding domain of transcriptional enhancer factor-1. EMBO J (1993) 1.68

Homeodomain leucine zipper class I genes in Arabidopsis. Expression patterns and phylogenetic relationships. Plant Physiol (2005) 1.67

PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. Mol Cell Biol (1999) 1.66

Sequence specificity of the core-binding factor. J Virol (1993) 1.63

Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes. Proc Natl Acad Sci U S A (1994) 1.61

Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res (1992) 1.51

Molecular evolution of the homeodomain family of transcription factors. Nucleic Acids Res (2001) 1.48

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol Cell Biol (1994) 1.45

An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J (1996) 1.44

Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucleic Acids Res (1996) 1.43

YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol Cell Biol (1995) 1.42

Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol (1996) 1.40

Functional specificity of the Antennapedia homeodomain. Proc Natl Acad Sci U S A (1993) 1.39

Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome. Am J Hum Genet (2000) 1.36

Common features in DNA recognition helices of eukaryotic transcription factors. EMBO J (1993) 1.36

A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J (1996) 1.34

Sequence-specific DNA binding by the MspI DNA methyltransferase. Nucleic Acids Res (1992) 1.34

Isolation and functional characterization of two distinct sexual-stage-specific promoters of the human malaria parasite Plasmodium falciparum. Mol Cell Biol (1999) 1.34

Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity. EMBO J (1995) 1.33

A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc Natl Acad Sci U S A (1996) 1.32

The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J (1993) 1.32

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J (1993) 1.32

A fungal mating type protein that regulates sexual and asexual development contains a POU-related domain. EMBO J (1992) 1.30

HOM/HOX homeobox genes are present in hydra (Chlorohydra viridissima) and are differentially expressed during regeneration. EMBO J (1992) 1.29

Interpreting protein/DNA interactions: distinguishing specific from non-specific and electrostatic from non-electrostatic components. Nucleic Acids Res (2010) 1.29

NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci U S A (1992) 1.27

The yeast alpha2 and Mcm1 proteins interact through a region similar to a motif found in homeodomain proteins of higher eukaryotes. Mol Cell Biol (1996) 1.25

Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25

Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets. Proc Natl Acad Sci U S A (1998) 1.24

Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo. Proc Natl Acad Sci U S A (1993) 1.20

The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol (1995) 1.20

A universal target sequence is bound in vitro by diverse homeodomains. Mech Dev (1993) 1.20

The Homeodomain Resource: 2003 update. Nucleic Acids Res (2003) 1.18

Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen. Mol Cell Biol (1994) 1.17

Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos. EMBO J (1993) 1.13

DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. Proc Natl Acad Sci U S A (1993) 1.11

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif. Nucleic Acids Res (1996) 1.10

Recognition of a DNA operator by a dimer composed of two different homeodomain proteins. EMBO J (1994) 1.09

Recognition models to predict DNA-binding specificities of homeodomain proteins. Bioinformatics (2012) 1.09

An analysis of the relationship between hydration and protein-DNA interactions. Biophys J (1998) 1.09

A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic Acids Res (2002) 1.08

GT-2: a transcription factor with twin autonomous DNA-binding domains of closely related but different target sequence specificity. EMBO J (1992) 1.08

A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74. Nucleic Acids Res (1993) 1.07

Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. Nucleic Acids Res (1993) 1.07

DNA-protein interactions at the S.cerevisiae alpha 2 operator in vivo. Nucleic Acids Res (1993) 1.06

Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A (1997) 1.06

Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera. Protein Sci (2003) 1.05

Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm. Mol Cell Biol (1994) 1.05

Reprogrammable recognition codes in bicoid homeodomain-DNA interaction. Mol Cell Biol (2000) 1.03

Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Proc Natl Acad Sci U S A (1996) 1.03

Transcriptional activation domains of the Candida albicans Gcn4p and Gal4p homologs. Eukaryot Cell (2006) 1.03

The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development. Plant Physiol (2006) 1.03

DNA bending by the a1 and alpha 2 homeodomain proteins from yeast. Nucleic Acids Res (1995) 1.03

Recognition of AT-rich DNA binding sites by the MogR repressor. Structure (2009) 1.03

Genetic identification of residues involved in association of alpha and beta G-protein subunits. Mol Cell Biol (1994) 1.02

Did homeodomain proteins duplicate before the origin of angiosperms, fungi, and metazoa? Proc Natl Acad Sci U S A (1997) 1.01

The Homeodomain Resource: sequences, structures, DNA binding sites and genomic information. Nucleic Acids Res (2001) 1.00

The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription. Mol Cell Biol (1998) 1.00

The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding. Mol Cell Biol (1999) 0.99

SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev (1997) 0.98

A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B. Proc Natl Acad Sci U S A (1993) 0.97

Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers. J Virol (1993) 0.96

The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain. EMBO J (1993) 0.96

Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro. Mol Cell Biol (1993) 0.95

Combined analysis of expression data and transcription factor binding sites in the yeast genome. BMC Genomics (2004) 0.95

Further elucidation of the genomic structure of PAX3, and identification of two different point mutations within the PAX3 homeobox that cause Waardenburg syndrome type 1 in two families. Am J Hum Genet (1995) 0.95

A trans-acting peptide activates the yeast a1 repressor by raising its DNA-binding affinity. EMBO J (1999) 0.95

Articles by these authors

Protein-DNA recognition. Annu Rev Biochem (1984) 22.02

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97

Cellular uptake of the tat protein from human immunodeficiency virus. Cell (1988) 10.19

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Ssn6-Tup1 is a general repressor of transcription in yeast. Cell (1992) 8.54

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions. Cell (1990) 7.99

The molecular basis of Turcot's syndrome. N Engl J Med (1995) 6.65

How the lambda repressor and cro work. Cell (1980) 6.65

DNA recognition by Cys2His2 zinc finger proteins. Annu Rev Biophys Biomol Struct (2000) 6.61

Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science (1997) 6.60

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (1994) 6.21

Epitaxial BiFeO3 multiferroic thin film heterostructures. Science (2003) 6.14

The operator-binding domain of lambda repressor: structure and DNA recognition. Nature (1982) 6.03

A repressor (MAT alpha 2 Product) and its operator control expression of a set of cell type specific genes in yeast. Cell (1985) 5.77

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science (1994) 5.70

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science (1993) 5.38

Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group. N Engl J Med (2000) 5.34

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions. Structure (1996) 5.30

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26

Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host. Science (2000) 5.22

Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature (1982) 5.21

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19

Interactions between DNA-bound repressors govern regulation by the lambda phage repressor. Proc Natl Acad Sci U S A (1979) 5.02

Quantitative model for gene regulation by lambda phage repressor. Proc Natl Acad Sci U S A (1982) 4.93

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (1997) 4.93

The yeast cell-type-specific repressor alpha 2 acts cooperatively with a non-cell-type-specific protein. Cell (1988) 4.82

Specific inhibition of Stat3 signal transduction by PIAS3. Science (1997) 4.74

Structure of the lambda complex at 2.5 A resolution: details of the repressor-operator interactions. Science (1988) 4.67

Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science (1988) 4.63

lambda Repressor and cro--components of an efficient molecular switch. Nature (1981) 4.52

Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science (1999) 4.14

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev (1993) 3.99

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell (1999) 3.98

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell (1994) 3.98

The lambda repressor contains two domains. Proc Natl Acad Sci U S A (1979) 3.68

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J (1999) 3.65

Mismatch repair deficiency in phenotypically normal human cells. Science (1995) 3.55

Bacteriophage lambda repressor and cro protein: interactions with operator DNA. Methods Enzymol (1980) 3.52

Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell (1994) 3.50

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45

Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet (1997) 3.41

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. Proc Natl Acad Sci U S A (2000) 3.35

Rapid elimination of low-copy DNA sequences in polyploid wheat: a possible mechanism for differentiation of homoeologous chromosomes. Genetics (1997) 3.28

Mutations of GTBP in genetically unstable cells. Science (1995) 3.23

Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code. J Mol Biol (1999) 3.20

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif (2012) 3.18

Refined 1.8 A crystal structure of the lambda repressor-operator complex. J Mol Biol (1992) 3.09

DNA recognition by beta-sheets in the Arc repressor-operator crystal structure. Nature (1994) 3.07

Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res (2001) 3.06

TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicans. Genetics (2000) 3.04

Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics (2000) 2.97

The N-terminal arms of lambda repressor wrap around the operator DNA. Nature (1982) 2.90

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry (1995) 2.90

Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci (2000) 2.83

The WD repeats of Tup1 interact with the homeo domain protein alpha 2. Genes Dev (1994) 2.80

Regulatory functions of the lambda repressor reside in the amino-terminal domain. Nature (1979) 2.77

a1 protein alters the DNA binding specificity of alpha 2 repressor. Cell (1988) 2.76

NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction. EMBO J (2001) 2.76

Automatic adjustment of pacemaker stimulation output correlated with continuously monitored capture thresholds: a multicenter study. European Microny Study Group. Pacing Clin Electrophysiol (1998) 2.76

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci (2000) 2.75

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73

A molecular, isozyme and morphological map of the barley (Hordeum vulgare) genome. Theor Appl Genet (1993) 2.66

Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65

A katanin-like protein regulates normal cell wall biosynthesis and cell elongation. Plant Cell (2001) 2.63

Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA. Science (1995) 2.63

Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. Cell (1995) 2.63

Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure (2001) 2.55

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev (1999) 2.54

Metal-dependent folding of a single zinc finger from transcription factor IIIA. Proc Natl Acad Sci U S A (1987) 2.53

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A (1997) 2.52

Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc Natl Acad Sci U S A (1998) 2.51

Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free. Genes Dev (1988) 2.50

MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet (1995) 2.49

The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J (2000) 2.44

A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an alpha 2 dimer. Cell (1992) 2.39

Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature (1999) 2.35

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1. Mol Cell Biol (1989) 2.33

DNA-binding specificity of Mcm1: operator mutations that alter DNA-bending and transcriptional activities by a MADS box protein. Mol Cell Biol (1997) 2.33

The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements. J Virol (1989) 2.32

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene (2011) 2.22

Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans. Mol Cell Biol (2001) 2.22

Identification of genes required for alpha 2 repression in Saccharomyces cerevisiae. Genetics (1995) 2.19

Transcriptional repression in eukaryotes. Annu Rev Cell Biol (1993) 2.17

Structure of the operator-binding domain of bacteriophage lambda repressor: implications for DNA recognition and gene regulation. Cold Spring Harb Symp Quant Biol (1983) 2.15

A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein. Cell (1993) 2.14

Mating in Candida albicans and the search for a sexual cycle. Annu Rev Microbiol (2005) 2.06

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell (1998) 2.00

A complex composed of tup1 and ssn6 represses transcription in vitro. J Biol Chem (1997) 1.97

The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics. Curr Biol (2001) 1.96

Transcriptional repression directed by the yeast alpha 2 protein in vitro. Nature (1994) 1.94

MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94

Vav2 is an activator of Cdc42, Rac1, and RhoA. J Biol Chem (2000) 1.93

Structure-based design of transcription factors. Science (1995) 1.93

Meiotic induction of the yeast HOP1 gene is controlled by positive and negative regulatory sites. Mol Cell Biol (1992) 1.92

Phenotypic switching in Candida albicans is controlled by a SIR2 gene. EMBO J (1999) 1.90

High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition. Structure (1998) 1.86

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85

Structural studies of the engrailed homeodomain. Protein Sci (1994) 1.85