Andreas Brech

Author PubWeight™ 146.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007 21.73
2 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
3 p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005 18.23
4 Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 2009 4.74
5 Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell 2004 4.53
6 The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 2009 4.31
7 Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol 2007 4.30
8 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2007 3.45
9 Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J 2006 3.07
10 Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol 2003 3.07
11 Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol 2008 2.90
12 FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 2010 2.57
13 ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol 2007 2.46
14 Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell 2010 2.37
15 Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci 2004 2.35
16 The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell 2010 2.12
17 p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 2010 1.93
18 The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell 2006 1.74
19 Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell 2006 1.68
20 Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci 2005 1.67
21 Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol 2010 1.65
22 A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res 2006 1.50
23 Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 2009 1.44
24 Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy 2009 1.43
25 Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci 2009 1.42
26 Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome. Int J Cancer 2011 1.39
27 Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol 2009 1.36
28 Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic 2007 1.35
29 Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell 2008 1.34
30 RILP is required for the proper morphology and function of late endosomes. J Cell Sci 2007 1.26
31 Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. J Cell Biol 2013 1.26
32 Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochim Biophys Acta 2012 1.25
33 CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J 2006 1.20
34 NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci 2012 1.16
35 The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates. Autophagy 2008 1.14
36 Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway. J Infect Dis 2010 1.06
37 ESCRT proteins in physiology and disease. Exp Cell Res 2008 1.04
38 Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. J Cell Sci 2009 1.04
39 Endocytic processing of connexin43 gap junctions: a morphological study. Biochem J 2006 1.03
40 Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity. Blood 2011 0.99
41 SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS One 2009 0.98
42 Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep 2012 0.98
43 Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo. J Cell Sci 2013 0.97
44 CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 2010 0.96
45 Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. J Cell Sci 2005 0.94
46 Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes. Biochem J 2003 0.93
47 Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43. J Cell Sci 2012 0.89
48 The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion. Traffic 2012 0.85
49 Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. PLoS One 2011 0.85
50 Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline. Dev Biol 2013 0.84
51 A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin. PLoS One 2013 0.82
52 Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus. J Cell Sci 2004 0.82
53 cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 2011 0.81
54 Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. J Biol Chem 2003 0.80
55 Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic 2014 0.80
56 Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells. Cancer Lett 2013 0.78
57 Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting. Traffic 2011 0.78
58 Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate. J Histochem Cytochem 2010 0.76
59 The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells. Biomaterials 2013 0.75