Published in Curr Biol on October 11, 2007
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol (2009) 2.69
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet (2009) 2.55
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol (2013) 2.18
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum Mol Genet (2009) 1.84
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
The role of lipids in the control of autophagy. Curr Biol (2013) 1.59
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta (2009) 1.56
Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. Development (2010) 1.55
Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell (2010) 1.55
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
ESCRTs are everywhere. EMBO J (2015) 1.40
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy (2011) 1.39
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell (2014) 1.27
A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell (2012) 1.26
Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness. Front Immunol (2014) 1.24
Molecules and their functions in autophagy. Exp Mol Med (2012) 1.21
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet (2012) 1.21
Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol (2008) 1.20
Autophagy takes flight in Drosophila. FEBS Lett (2010) 1.15
Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet (2012) 1.13
The role of PI3P phosphatases in the regulation of autophagy. FEBS Lett (2010) 1.13
Myosin VI and its cargo adaptors - linking endocytosis and autophagy. J Cell Sci (2013) 1.12
Miz1 is required to maintain autophagic flux. Nat Commun (2013) 1.12
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic (2009) 1.12
Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays (2013) 1.10
Autophagy and misfolded proteins in neurodegeneration. Exp Neurol (2010) 1.10
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO Rep (2015) 1.09
Autophagy in Drosophila melanogaster. Biochim Biophys Acta (2009) 1.06
ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Traffic (2009) 1.05
Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol (2013) 1.05
Assays to monitor autophagy in Drosophila. Methods (2014) 1.04
Regulation of membrane protein degradation by starvation-response pathways. Traffic (2012) 1.04
Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. EMBO Mol Med (2013) 1.04
Cell-autonomous requirement for DNaseII in nonapoptotic cell death. Cell Death Differ (2009) 1.04
Physiological and cellular responses caused by RNAi- mediated suppression of Snf7 orthologue in western corn rootworm (Diabrotica virgifera virgifera) larvae. PLoS One (2013) 1.04
Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? Exp Neurobiol (2012) 1.03
Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J Clin Invest (2014) 0.98
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim Biophys Acta (2009) 0.98
Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P. EMBO J (2012) 0.97
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol (2015) 0.95
Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proc Natl Acad Sci U S A (2015) 0.95
Disruption of Vps4 and JNK function in Drosophila causes tumour growth. PLoS One (2009) 0.94
The late stage of autophagy: cellular events and molecular regulation. Protein Cell (2010) 0.94
The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis. Plant Cell (2013) 0.94
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature (2014) 0.94
Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell (2014) 0.93
Anti-glycoprotein H antibody impairs the pathogenicity of varicella-zoster virus in skin xenografts in the SCID mouse model. J Virol (2010) 0.92
How and why to study autophagy in Drosophila: it's more than just a garbage chute. Methods (2014) 0.91
Eaten alive: novel insights into autophagy from multicellular model systems. Trends Cell Biol (2015) 0.91
SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. J Biol Chem (2009) 0.90
Mechanisms and functions of endocytosis. J Cell Biol (2008) 0.90
The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis. BMC Dev Biol (2012) 0.90
Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. Proc Natl Acad Sci U S A (2012) 0.90
Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia. Mol Cell Biol (2012) 0.90
Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am J Pathol (2008) 0.89
Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens. PLoS Pathog (2014) 0.88
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia. J Cell Biol (2015) 0.87
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PLoS One (2013) 0.87
Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1. PLoS Genet (2009) 0.86
Bioanalysis of eukaryotic organelles. Chem Rev (2013) 0.86
An overview of the rare parotid gland cancer. Head Neck Oncol (2011) 0.86
Computational model for autophagic vesicle dynamics in single cells. Autophagy (2012) 0.85
Genes for plant autophagy: functions and interactions. Mol Cells (2012) 0.85
Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85
How to take autophagy and endocytosis up a notch. Biomed Res Int (2014) 0.85
Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo. J Cell Sci (2014) 0.84
Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell (2013) 0.84
Ultrastructural changes caused by Snf7 RNAi in larval enterocytes of western corn rootworm (Diabrotica virgifera virgifera Le Conte). PLoS One (2014) 0.83
The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell (2015) 0.83
Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy (2014) 0.82
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. J Biol Chem (2013) 0.82
The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation. Elife (2015) 0.81
Route to destruction: autophagosomes SNARE lysosomes. J Cell Biol (2013) 0.81
Need an ESCRT for autophagosomal maturation? Commun Integr Biol (2012) 0.79
A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol (2015) 0.79
New Ca(2+)-dependent regulators of autophagosome maturation. Commun Integr Biol (2012) 0.79
Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time. Biochem Soc Trans (2016) 0.79
Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101. Cell Death Dis (2015) 0.78
The Genomic Basis of Postponed Senescence in Drosophila melanogaster. PLoS One (2015) 0.78
Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes. Biol Open (2015) 0.78
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. J Cell Biol (2009) 0.78
Selective endosomal microautophagy is starvation-inducible in Drosophila. Autophagy (2016) 0.77
The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy. Mol Biol Cell (2016) 0.77
Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury. Mol Neurobiol (2017) 0.76
The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice. Sci Rep (2017) 0.75
Insights into autophagosome biogenesis from in vitro reconstitutions. J Struct Biol (2016) 0.75
Autophagy in endosomal mutants: Desperately seeking to survive. Worm (2012) 0.75
Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control. PLoS One (2017) 0.75
Signaling by the engulfment receptor draper: a screen in Drosophila melanogaster implicates cytoskeletal regulators, Jun N-terminal Kinase, and Yorkie. Genetics (2014) 0.75
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol (2002) 5.83
Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol (2009) 4.74
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol (2009) 4.31
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Altered modes of stem cell division drive adaptive intestinal growth. Cell (2011) 3.58
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45
The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell (2005) 3.17
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell (2003) 2.97
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol (2005) 2.77
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol (2010) 2.57
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet (2006) 2.47
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat Cell Biol (2008) 2.38
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell (2010) 2.37
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol (2009) 2.21
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet (2008) 2.16
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Mass transit: epithelial morphogenesis in the Drosophila egg chamber. Dev Dyn (2005) 2.07
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
Global tissue revolutions in a morphogenetic movement controlling elongation. Science (2011) 1.95
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet (2009) 1.82
Endocytosis and signaling. Curr Opin Cell Biol (2011) 1.78
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res (2010) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci (2002) 1.74
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell (2006) 1.68
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol (2010) 1.65
Autophagy in tumour suppression and promotion. Mol Oncol (2009) 1.64
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin. EMBO Rep (2012) 1.57
A fluorescent reporter of caspase activity for live imaging. Proc Natl Acad Sci U S A (2008) 1.55
Accelerated homologous recombination and subsequent genome modification in Drosophila. Development (2013) 1.55
Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol (2005) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Endocytosis: a positive or a negative influence on Wnt signalling? Traffic (2007) 1.46
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic (2009) 1.44
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem (2005) 1.43
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42