Published in Mol Biol Cell on July 12, 2006
Endosome maturation. EMBO J (2011) 5.22
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature (2009) 2.68
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell (2009) 1.90
PIKfyve: Partners, significance, debates and paradoxes. Cell Biol Int (2008) 1.87
Endosomal phosphoinositides and human diseases. Traffic (2008) 1.64
Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) (2009) 1.56
Multivesicular bodies: co-ordinated progression to maturity. Curr Opin Cell Biol (2008) 1.45
The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors. Nat Immunol (2016) 1.44
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell (2008) 1.40
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog (2010) 1.39
PIKfyve regulation of endosome-linked pathways. Traffic (2009) 1.39
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development (2010) 1.36
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice. J Biol Chem (2011) 1.32
Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes. Development (2009) 1.29
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. J Mol Biol (2008) 1.24
Miz1 is required to maintain autophagic flux. Nat Commun (2013) 1.12
Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays (2013) 1.10
Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J Cell Biol (2010) 1.09
Drosophila TRPML is required for TORC1 activation. Curr Biol (2012) 1.06
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder. J Biol Chem (2010) 1.03
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. J Biol Chem (2009) 1.00
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. J Cell Biol (2009) 1.00
Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3. Am J Physiol Endocrinol Metab (2008) 0.98
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol (2015) 0.94
The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase. Mol Biol Cell (2014) 0.92
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A (2013) 0.91
Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem (2013) 0.90
At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression. Mol Oncol (2009) 0.87
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PLoS One (2013) 0.87
Phosphatidylinositol 3-Phosphate 5-Kinase, FAB1/PIKfyve Kinase Mediates Endosome Maturation to Establish Endosome-Cortical Microtubule Interaction in Arabidopsis. Plant Physiol (2015) 0.84
The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole. J Biol Chem (2015) 0.83
PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Dev Cell (2016) 0.82
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. J Biol Chem (2013) 0.82
Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy (2014) 0.82
A novel mutation (p.Glu1389AspfsX16) of the phosphoinositide kinase, FYVE finger containing gene found in a Japanese patient with fleck corneal dystrophy. Mol Vis (2012) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol (2012) 0.81
Fig4 deficiency: a newly emerged lysosomal storage disorder? Prog Neurobiol (2012) 0.80
FIG4 regulates lysosome membrane homeostasis independent of phosphatase function. Hum Mol Genet (2015) 0.80
Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes. Biol Open (2015) 0.78
The Amyloid Precursor Protein Controls PIKfyve Function. PLoS One (2015) 0.78
A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. PLoS Genet (2015) 0.77
Hemotin, a Regulator of Phagocytosis Encoded by a Small ORF and Conserved across Metazoans. PLoS Biol (2016) 0.75
MiniCORVET is a Vps8-containing early endosomal tether in Drosophila. Elife (2016) 0.75
Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J (2000) 7.48
Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell (2003) 7.42
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development (2000) 6.40
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell (1998) 6.07
Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol (2002) 5.05
Systematic gain-of-function genetics in Drosophila. Development (1998) 4.71
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell (2000) 4.20
Gradient formation of the TGF-beta homolog Dpp. Cell (2000) 3.91
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature (1994) 3.72
Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell (2002) 3.72
Site-specific recombination between homologous chromosomes in Drosophila. Science (1991) 3.70
Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis. Nature (1997) 3.50
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J Cell Biol (2003) 3.26
The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell (2005) 3.17
Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell (2005) 3.10
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol (2002) 2.94
Visualization of gene expression in living adult Drosophila. Science (1996) 2.92
Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell (2005) 2.81
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell (2005) 2.57
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol (2002) 2.52
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. J Cell Sci (2001) 2.48
Cell biology of the presynaptic terminal. Annu Rev Neurosci (2003) 2.48
A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila. Mol Cell (1999) 2.34
Regulation of signal transduction by endocytosis. Curr Opin Cell Biol (2000) 2.28
Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol Cell (2000) 2.23
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
Regulated endocytic routing modulates wingless signaling in Drosophila embryos. Cell (2001) 2.03
The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett (2002) 1.96
Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell (1992) 1.91
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve. J Biol Chem (2001) 1.88
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Mol Biol Cell (2003) 1.62
The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Curr Opin Cell Biol (2005) 1.61
Signal dispersal and transduction through the endocytic pathway. Nat Rev Mol Cell Biol (2003) 1.61
The PX domain: a new phosphoinositide-binding module. J Cell Sci (2002) 1.60
Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep (2003) 1.60
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci (2004) 1.54
Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate. Semin Cell Dev Biol (2001) 1.34
Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs. Development (2005) 1.19
Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Genetics (2002) 1.08
Morphogen transport along epithelia, an integrated trafficking problem. Dev Cell (2002) 1.07
The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila. Development (2003) 1.06
Function of the spalt/spalt-related gene complex in positioning the veins in the Drosophila wing. Mech Dev (2000) 1.03
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1. Gene (2006) 1.01
How are the sizes of cells, organs, and bodies controlled? PLoS Biol (2003) 1.00
Modulation of developmental signals by endocytosis: different means and many ends. Curr Opin Cell Biol (2003) 1.00
adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS. Development (1999) 0.94
Phosphatidylinositol 3,5-bisphosphate: metabolism and function. Arch Biochem Biophys (2002) 0.84
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol (2002) 5.83
Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol (2009) 4.74
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol (2009) 4.31
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell (2003) 2.97
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol (2010) 2.57
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell (2010) 2.37
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet (2008) 2.16
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88
Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea. Curr Biol (2006) 1.87
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila. Dev Cell (2007) 1.79
Endocytosis and signaling. Curr Opin Cell Biol (2011) 1.78
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res (2010) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci (2002) 1.74
A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila trachea. Dev Cell (2005) 1.73
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol (2010) 1.65
Autophagy in tumour suppression and promotion. Mol Oncol (2009) 1.64
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin. EMBO Rep (2012) 1.57
Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems. Trends Cell Biol (2003) 1.52
Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol (2005) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic (2009) 1.44
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42
Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev (2004) 1.41
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome. Int J Cancer (2011) 1.39
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol (2009) 1.36
Cytokinesis and cancer. FEBS Lett (2010) 1.36
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic (2002) 1.35
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic (2007) 1.35
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell (2008) 1.34
Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development (2002) 1.31
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain. Nat Struct Mol Biol (2006) 1.27
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes. Histochem Cell Biol (2003) 1.27