Published in Mol Carcinog on November 01, 2006
VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71
Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells. J Clin Invest (2010) 2.06
Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget (2012) 1.37
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol (2011) 1.30
Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem J (2011) 1.14
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem J (2010) 1.07
Function of members of the neuropilin family as essential pleiotropic cell surface receptors. Biochemistry (2012) 0.99
Neuropilins: expression and roles in the epithelium. Int J Exp Pathol (2012) 0.98
The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis. J Biol Chem (2012) 0.98
Receptor complexes for each of the Class 3 Semaphorins. Front Cell Neurosci (2012) 0.97
Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1. Mol Cancer (2010) 0.96
The emerging role of class-3 semaphorins and their neuropilin receptors in oncology. Onco Targets Ther (2014) 0.86
Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors. PLoS One (2013) 0.84
2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axis. Mol Cancer Ther (2010) 0.83
CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation. Oncogene (2014) 0.83
Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Front Oncol (2015) 0.83
Increased expression of neuropilin 1 in melanoma progression and its prognostic significance in patients with melanoma. Mol Med Rep (2015) 0.81
GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis. Oncotarget (2016) 0.80
A perspective on the role of class III semaphorin signaling in central nervous system trauma. Front Cell Neurosci (2014) 0.80
Pericytes on the tumor vasculature: jekyll or hyde? Cancer Microenviron (2012) 0.80
Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury. Cardiovasc Res (2015) 0.79
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol (2015) 0.79
The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. Oncotarget (2016) 0.79
Neuropilin Functions as an Essential Cell Surface Receptor. J Biol Chem (2015) 0.78
Pancreatic tumor cell secreted CCN1/Cyr61 promotes endothelial cell migration and aberrant neovascularization. Sci Rep (2014) 0.78
Neuropilins and liver. World J Gastroenterol (2015) 0.75
The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature. Curr Opin Hematol (2016) 0.75
NRP1 transport of cancer therapeutics mediated by tumor-penetrating peptides. Drugs Future (2017) 0.75
Engineering vascularized skeletal muscle tissue. Nat Biotechnol (2005) 7.73
Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med (2006) 6.21
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest (2005) 3.77
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One (2008) 3.46
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A (2009) 2.59
Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development (2002) 2.57
Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol (2004) 2.56
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med (2003) 2.52
Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol (2007) 2.27
Vascular endothelial growth factor localization in the adult. Am J Pathol (2006) 2.20
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev (2008) 1.73
RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J (2010) 1.67
Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res (2008) 1.65
VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci (2006) 1.59
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.58
VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med (2008) 1.54
Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Dev Dyn (2006) 1.54
Forty-year journey of angiogenesis translational research. Sci Transl Med (2011) 1.51
Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. Cancer Res (2005) 1.51
Roles for VEGF in the adult. Microvasc Res (2007) 1.48
TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One (2009) 1.38
Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev (2005) 1.35
Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell (2007) 1.26
Defective pulmonary development in the absence of heparin-binding vascular endothelial growth factor isoforms. Am J Respir Cell Mol Biol (2002) 1.25
Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis. Mol Cancer (2011) 1.23
Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci (2012) 1.21
Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 1.21
Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp Eye Res (2003) 1.19
Pericyte isolation and use in endothelial/pericyte coculture models. Methods Enzymol (2008) 1.19
Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol (2011) 1.17
Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer. Int J Cancer (2002) 1.16
Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling. Arterioscler Thromb Vasc Biol (2009) 1.14
The role of hypoxia in vascular injury and repair. Annu Rev Pathol (2008) 1.14
Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Cancer Lett (2007) 1.13
Endothelial cell-astrocyte interactions and TGF beta are required for induction of blood-neural barrier properties. Brain Res Dev Brain Res (2004) 1.13
Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation. Stem Cells Dev (2004) 1.13
Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways. Biochemistry (2006) 1.11
Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther (2009) 1.11
Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. Cancer Res (2008) 1.10
Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis (2006) 1.10
CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. Cancer Res (2008) 1.09
Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization. J Cell Sci (2007) 1.08
Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A (2013) 1.08
VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis. Biochemistry (2008) 1.06
Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not. Growth Factors (2007) 1.03
Identification of genes involved in VEGF-mediated vascular morphogenesis using embryonic stem cell-derived cystic embryoid bodies. Lab Invest (2004) 1.02
Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment. Cancer Res (2010) 1.01
Arterial versus venous endothelial cells. Cell Tissue Res (2008) 1.01
Getting Tie(2)d up in angiogenesis. J Clin Invest (2002) 1.00
Evaluation of a multi-pronged intervention to improve access to safe abortion care in two districts in Jharkhand. BMC Health Serv Res (2014) 0.99
WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. Neoplasia (2003) 0.99
The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci (2011) 0.99
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol. Mol Cancer Res (2004) 0.98
The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis. J Biol Chem (2012) 0.98
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J (2013) 0.97
A brief history of anti-VEGF for the treatment of ocular angiogenesis. Am J Pathol (2012) 0.96
Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells. Cancer Res (2007) 0.96
Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1. Mol Cancer (2010) 0.96
Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. J Biol Chem (2011) 0.96
Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations. J Mol Med (Berl) (2004) 0.95
Repression of vascular endothelial growth factor expression by the zinc finger transcription factor ZNF24. Cancer Res (2007) 0.92
Molecular regulation of vascular endothelial growth factor expression in the retinal pigment epithelium. Mol Vis (2012) 0.92
Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway. Int J Oncol (2003) 0.91
CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet (2005) 0.90
The function of vascular endothelial growth factor. Biofactors (2009) 0.90
Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res (2005) 0.90
Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci (2008) 0.90
VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg (2004) 0.90
Therapeutic angiogenesis for cardiovascular disease. Curr Control Trials Cardiovasc Med (2001) 0.89
Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Dev Biol (2011) 0.89