Published in Sci Transl Med on December 21, 2011
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem (2013) 1.62
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
Micro-CT imaging of tumor angiogenesis: quantitative measures describing micromorphology and vascularization. Am J Pathol (2013) 1.23
Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol (2013) 1.13
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A (2013) 1.07
Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. Anticancer Agents Med Chem (2013) 1.00
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients. Proc Natl Acad Sci U S A (2015) 0.97
Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery. J Transl Med (2012) 0.96
Spheroid Culture of Mesenchymal Stem Cells. Stem Cells Int (2015) 0.96
Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proc Natl Acad Sci U S A (2013) 0.95
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts. J Mol Med (Berl) (2013) 0.95
Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta (2013) 0.94
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues. Proc Natl Acad Sci U S A (2014) 0.92
Macrophages in collateral arteriogenesis. Front Physiol (2012) 0.90
Monitoring tumor response to linifanib therapy with SPECT/CT using the integrin αvβ3-targeted radiotracer 99mTc-3P-RGD2. J Pharmacol Exp Ther (2013) 0.88
Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nat Commun (2014) 0.85
Slug promoted vasculogenic mimicry in hepatocellular carcinoma. J Cell Mol Med (2013) 0.85
Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors. Angiogenesis (2012) 0.85
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A (2013) 0.84
Human proangiogenic circulating hematopoietic stem and progenitor cells promote tumor growth in an orthotopic melanoma xenograft model. Angiogenesis (2013) 0.83
Future options of anti-angiogenic cancer therapy. Chin J Cancer (2016) 0.83
Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes. Sci Rep (2015) 0.82
Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype. Nat Commun (2015) 0.81
Anti-angiogenic effects of a mutant endostatin: a new prospect for treating retinal and choroidal neovascularization. PLoS One (2014) 0.81
Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway. Oncotarget (2015) 0.80
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model. Sci Rep (2015) 0.79
Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis. Clin Cancer Res (2016) 0.79
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A. Oncogenesis (2014) 0.79
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Carcinogenesis (2015) 0.78
Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. Microvasc Res (2014) 0.78
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Nat Commun (2016) 0.78
Myeloid Cells as Targets for Therapy in Solid Tumors. Cancer J (2015) 0.78
Pericyte-fibroblast transition promotes tumor growth and metastasis. Proc Natl Acad Sci U S A (2016) 0.78
Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis. Cell Mol Life Sci (2016) 0.77
Implantable tissue isolation chambers for analyzing tumor dynamics in vivo. Lab Chip (2016) 0.77
Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy. Proc Natl Acad Sci U S A (2016) 0.77
C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling. J Mol Med (Berl) (2016) 0.76
Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. Arterioscler Thromb Vasc Biol (2014) 0.76
Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway. J Biol Chem (2015) 0.75
Targeting osteosarcoma vasculature with peptide obtained by phage display. Contemp Oncol (Pozn) (2014) 0.75
Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces "angiogenic switch off" in a hepatoma mouse model. Mol Ther Oncolytics (2015) 0.75
Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors. Sci Rep (2016) 0.75
Three-Dimensional Characterization of Mechanical Interactions between Endothelial Cells and Extracellular Matrix during Angiogenic Sprouting. Sci Rep (2016) 0.75
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep (2017) 0.75
IDO1 is an Integral Mediator of Inflammatory Neovascularization. EBioMedicine (2016) 0.75
Tongxinluo mitigates atherogenesis by regulating angiogenic factors and inhibiting vasa vasorum neovascularization in apolipoprotein E-deficient mice. Oncotarget (2016) 0.75
PPARG is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target. EMBO Mol Med (2017) 0.75
Angiopoietin pathway gene expression associated with poor breast cancer survival. Breast Cancer Res Treat (2017) 0.75
De novo protein sequencing, humanization and in vitro effects of an antihuman CD34 mouse monoclonal antibody. Biochem Biophys Rep (2016) 0.75
Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol (2007) 17.80
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov (2009) 12.46
Engineering vascularized skeletal muscle tissue. Nat Biotechnol (2005) 7.73
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A (2006) 6.90
Impact of nanotechnology on drug delivery. ACS Nano (2009) 6.87
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol (2008) 6.81
Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A (2006) 6.66
Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med (2006) 6.21
Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med (2012) 5.92
Reconstituting organ-level lung functions on a chip. Science (2010) 5.75
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol (2004) 5.51
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41
Transdermal drug delivery. Nat Biotechnol (2008) 5.11
Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A (2002) 4.77
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A (2008) 4.57
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res (2004) 4.56
Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial. Am J Epidemiol (2005) 4.55
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (2008) 4.46
A tough biodegradable elastomer. Nat Biotechnol (2002) 4.35
Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A (2010) 4.25
Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A (2004) 4.13
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials (2006) 4.09
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med (2005) 4.04
Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat Mater (2008) 4.00
A reversibly switching surface. Science (2003) 3.97
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Small-scale systems for in vivo drug delivery. Nat Biotechnol (2003) 3.90
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A (2008) 3.80
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest (2005) 3.77
Nanoparticle delivery of cancer drugs. Annu Rev Med (2011) 3.75
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell (2005) 3.74
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70
Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2002) 3.66
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A (2008) 3.62
First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med (2012) 3.56
Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol (2009) 3.55
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One (2008) 3.46
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J (2002) 3.45
Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules (2005) 3.44
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (2010) 3.43
Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov (2004) 3.41
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci (2006) 3.35
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A (2002) 3.35
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33
Treating metastatic cancer with nanotechnology. Nat Rev Cancer (2011) 3.30
Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.19
Mechanical control of tissue and organ development. Development (2010) 3.18
Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med (2008) 3.16
Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol (2010) 3.15
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol (2012) 3.09
Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl (2009) 3.09
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci (2006) 2.98
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92
Microengineered hydrogels for tissue engineering. Biomaterials (2007) 2.87
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A (2003) 2.86
Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl (2003) 2.83
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
The inflammatory responses to silk films in vitro and in vivo. Biomaterials (2005) 2.79
Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science (2002) 2.79
Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res (2004) 2.78
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano (2008) 2.76
Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun (2003) 2.71
Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev (2006) 2.69
Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat Mater (2003) 2.65
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell (2013) 2.64
A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res (2008) 2.63
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A (2009) 2.59
A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A (2008) 2.58
Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater (2012) 2.57
Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development (2002) 2.57
Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol (2004) 2.56
VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J Cell Biochem (2002) 2.53
Light-induced shape-memory polymers. Nature (2005) 2.52
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med (2003) 2.52
Calcification of multipotent prostate tumor endothelium. Cancer Cell (2008) 2.49
Risk of cardiovascular disease by hysterectomy status, with and without oophorectomy: the Women's Health Initiative Observational Study. Circulation (2005) 2.49
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature (2004) 2.48
Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton (2002) 2.45
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A (2003) 2.45
High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res (2007) 2.43
Cell tension, matrix mechanics, and cancer development. Cancer Cell (2005) 2.42
Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol (2003) 2.42
Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett (2007) 2.40
A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A (2013) 2.40
Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther (2009) 2.39
Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force. Genet Med (2002) 2.39