Published in J Med Chem on July 27, 2006
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther (2009) 1.63
RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem (2010) 1.18
Natural products as a source of Alzheimer's drug leads. Nat Prod Rep (2010) 1.13
Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ Health Perspect (2010) 1.03
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The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect (2006) 3.81
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Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97
Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology (2006) 1.97
Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet (2010) 1.95
Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun (2008) 1.89
Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology (2007) 1.87
In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect (2008) 1.82
Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun (2008) 1.79
Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol (2009) 1.77
NMR quantitation of natural products at the nanomole scale. J Nat Prod (2009) 1.69
Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci (2007) 1.68
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Res (2003) 1.67
Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation. Immunol Cell Biol (2013) 1.60
Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus. J Nat Prod (2009) 1.60
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A (2009) 1.57
Gene expression changes in children with autism. Genomics (2007) 1.55
Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene. Mol Pharmacol (2008) 1.55
Altered T cell responses in children with autism. Brain Behav Immun (2010) 1.53
Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A (2004) 1.51
The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol (2009) 1.50
Photolabile ruthenium nitrosyls with planar dicarboxamide tetradentate N(4) ligands: effects of in-plane and axial ligand strength on NO release. Inorg Chem (2004) 1.47
Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol (2010) 1.46
Facile ring opening of iron(III) and iron(II) complexes of meso-amino-octaethylporphyrin by dioxygen. J Am Chem Soc (2004) 1.42
Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol (2008) 1.41
Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling. J Biol Chem (2003) 1.38
PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environ Sci Technol (2010) 1.38
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res (2008) 1.37
Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Plant J (2004) 1.34
A double concave hydrocarbon buckycatcher. J Am Chem Soc (2007) 1.34
Increased IgG4 levels in children with autism disorder. Brain Behav Immun (2008) 1.32
Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicol Sci (2005) 1.32
Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD. J Am Chem Soc (2007) 1.28
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environ Health Perspect (2008) 1.27
Hydroxonium hydrate tris-(2,4,6-tri-amino-1,3,5-triazin-1-ium) bis-[bis-(pyri-dine-2,6-dicarboxyl-ato)cuprate(II)] pyridine-2,6-dicarboxylic acid hexa-hydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.26
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J Biol Chem (2007) 1.25
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect (2012) 1.25
Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet (2010) 1.24
Lobocyclamides A-C, lipopeptides from a cryptic cyanobacterial mat containing Lyngbya confervoides. J Org Chem (2002) 1.24
Global increases in both common and rare copy number load associated with autism. Hum Mol Genet (2013) 1.24
Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins. J Biol Chem (2006) 1.23
Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations. J Biol Chem (2007) 1.22
Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. J Biol Chem (2003) 1.22
Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biol Psychiatry (2013) 1.21
MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res (2008) 1.19
Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet (2012) 1.19
Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect (2009) 1.19
Evidence for conformational coupling between two calcium channels. Proc Natl Acad Sci U S A (2004) 1.18
RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem (2010) 1.18
Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. J Biol Chem (2003) 1.17
Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ Health Perspect (2005) 1.17
Long-range stereo-relay: relative and absolute configuration of 1,n-glycols from circular dichroism of liposomal porphyrin esters. J Am Chem Soc (2004) 1.17
Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels. Biochem J (2007) 1.17
Long-chain 2H-azirines with heterogeneous terminal halogenation from the marine sponge Dysidea fragilis. J Org Chem (2008) 1.16
Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Hum Mol Genet (2012) 1.15
Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR. Am J Physiol Cell Physiol (2006) 1.14
Phorbasides A-E, cytotoxic chlorocyclopropane macrolide glycosides from the marine sponge Phorbas sp. CD determination of C-methyl sugar configurations. J Org Chem (2008) 1.14
1,10-Phenanthrolin-1-ium hydrogen (S,S)-tartrate trihydrate and a correction. Acta Crystallogr Sect E Struct Rep Online (2009) 1.14
A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale. J Am Chem Soc (2009) 1.14
Energetics and structural consequences of axial ligand coordination in nonplanar nickel porphyrins. J Am Chem Soc (2005) 1.13
PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect (2012) 1.12
Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A (2012) 1.12
Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet (2012) 1.12
Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem (2002) 1.12
2-[(3,5-Di-tert-butyl-4-hy-droxy-benz-yl)sulfan-yl]benzoic acid. Acta Crystallogr Sect E Struct Rep Online (2010) 1.11
Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. J Biol Chem (2005) 1.11
Behavioral correlates of maternal antibody status among children with autism. J Autism Dev Disord (2012) 1.11
Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem (2012) 1.10
PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect (2012) 1.10
Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen (2012) 1.09
Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophys J (2008) 1.09
One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A (2003) 1.09
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A (2012) 1.08
Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica. Angew Chem Int Ed Engl (2012) 1.08
Spontaneous reduction of a low-spin Fe(III) complex of a neutral pentadentate N(5) Schiff base ligand to the corresponding Fe(II) species in acetonitrile. Inorg Chem (2002) 1.07
Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. Angew Chem Int Ed Engl (2004) 1.06
Incorporation of μ(3)-CO(3) into an Mn/Mn Mn(12) cluster: {[(cyclam)Mn(μ-O)(2)Mn(H(2)O)(μ-OH)](6)(μ(3)-CO(3))(2)}Cl(8)·24H(2)O. Acta Crystallogr Sect E Struct Rep Online (2010) 1.06
Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis. J Nat Prod (2005) 1.06
Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1. J Biol Chem (2004) 1.05
Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. J Biol Chem (2004) 1.05
Isolation and structural characterization of a family of endohedral fullerenes including the large, chiral cage fullerenes Tb(3)N@C(88) and Tb(3)N@C(86) as well as the I(h) and D(5)(h) isomers of Tb(3)N@C(80). J Am Chem Soc (2007) 1.04
Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem (2013) 1.04
Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ Health Perspect (2010) 1.03
The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model. Biochemistry (2003) 1.03
A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR. J Gen Physiol (2010) 1.02
Synthesis and characterization of three-coordinate and related beta-diketiminate derivatives of manganese, iron, and cobalt. Inorg Chem (2002) 1.02
Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicol Teratol (2011) 1.02
Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO. Inorg Chem (2004) 1.00
Near-infrared light activated release of nitric oxide from designed photoactive manganese nitrosyls: strategy, design, and potential as NO donors. J Am Chem Soc (2008) 1.00
Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A (2011) 1.00
(+)-Zwittermicin A: assignment of its complete configuration by total synthesis of the enantiomer and implication of D-serine in its biosynthesis. Angew Chem Int Ed Engl (2008) 0.99
Synthesis of 7-(15)N-Oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale (1)H-(15)N HSQC and FTMS. J Nat Prod (2010) 0.99