Published in Neurobiol Aging on July 20, 2006
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ (2010) 7.93
Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke (2010) 3.75
Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adults. J Am Geriatr Soc (2008) 3.21
Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health Study. J Am Geriatr Soc (2011) 1.87
Subtle neurological abnormalities as risk factors for cognitive and functional decline, cerebrovascular events, and mortality in older community-dwelling adults. Arch Intern Med (2008) 1.71
Total and cause-specific mortality in the cardiovascular health study. J Gerontol A Biol Sci Med Sci (2009) 1.53
A physiologic index of comorbidity: relationship to mortality and disability. J Gerontol A Biol Sci Med Sci (2008) 1.48
Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 1.08
White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes. Neurology (2015) 0.92
Association of a Modified Physiologic Index with mortality and incident disability: the Health, Aging, and Body Composition study. J Gerontol A Biol Sci Med Sci (2012) 0.91
Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial. J Clin Hypertens (Greenwich) (2010) 0.90
Anemia is associated with the progression of white matter disease in older adults with high blood pressure: the cardiovascular health study. J Am Geriatr Soc (2008) 0.90
Multisystem physiologic impairments and changes in gait speed of older adults. J Gerontol A Biol Sci Med Sci (2014) 0.90
Methadone use in a male with the FMRI premutation and FXTAS. Am J Med Genet A (2015) 0.89
Long-term survival in adults 65 years and older with white matter hyperintensity: association with performance on the digit symbol substitution test. Psychosom Med (2013) 0.87
Neuropathological approaches to cerebral aging and neuroplasticity. Dialogues Clin Neurosci (2013) 0.87
A population-based study on the influence of brain atrophy on 20-year survival after age 85. Neurology (2011) 0.85
Progression of magnetic resonance imaging-defined brain vascular disease predicts vascular events in elderly: the Cardiovascular Health Study. Stroke (2011) 0.85
Diabetes predicts long-term disability in an elderly urban cohort: the Northern Manhattan Study. Ann Epidemiol (2014) 0.84
Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based Sample: Age Gene/Environment Susceptibility-Reykjavik Study. J Gerontol A Biol Sci Med Sci (2014) 0.83
White matter disease as a biomarker for long-term cerebrovascular disease and dementia. Curr Treat Options Cardiovasc Med (2014) 0.82
Dementia and Alzheimer's disease: a new direction.The 2010 Jay L. Foster Memorial Lecture. Alzheimers Dement (2011) 0.82
WebParc: a tool for analysis of the topography and volume of stroke from MRI. Med Biol Eng Comput (2010) 0.81
Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens (2014) 0.81
Regional white matter hyperintensity volume and cognition predict death in a multiethnic community cohort of older adults. J Am Geriatr Soc (2013) 0.78
Establishing the bidirectional relationship between depression and subclinical arteriosclerosis--rationale, design, and characteristics of the BiDirect Study. BMC Psychiatry (2014) 0.78
Long-term Cognitive Trajectories and Mortality in Older Women. J Gerontol A Biol Sci Med Sci (2016) 0.76
Effects of Disease Burden and Functional Adaptation on Morbidity and Mortality on Older Adults. J Am Geriatr Soc (2016) 0.75
Structural brain changes and all-cause mortality in the elderly population-the mediating role of inflammation. Age (Dordr) (2016) 0.75
Preoperative white matter lesions are independent predictors of long-term survival after internal carotid endarterectomy. Cerebrovasc Dis Extra (2014) 0.75
MRI Markers Predict Cognitive Decline Assessed by Telephone Interview: The Northern Manhattan Study. Alzheimer Dis Assoc Disord (2016) 0.75
Whole blood gene expression and white matter Hyperintensities. Mol Neurodegener (2017) 0.75
Blood Pressure and Heart Rate Measures Associated With Increased Risk of Covert Brain Infarction and Worsening Leukoaraiosis in Older Adults. Arterioscler Thromb Vasc Biol (2017) 0.75
Subclinical Cerebrovascular Disease Increases the Risk of Incident Stroke and Mortality: The Northern Manhattan Study. J Am Heart Assoc (2017) 0.75
Differential Effect of Left vs. Right White Matter Hyperintensity Burden on Functional Decline: The Northern Manhattan Study. Front Aging Neurosci (2017) 0.75
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA (2005) 20.53
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med (2008) 18.34
Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med (2005) 15.30
Gait speed and survival in older adults. JAMA (2011) 15.01
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA (2010) 8.90
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
How to interpret a genome-wide association study. JAMA (2008) 7.54
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2006) 7.38
Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med (2009) 7.06
Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep (2006) 6.98
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group. Circ Cardiovasc Genet (2010) 6.74
Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc (2005) 6.73
Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci (2006) 6.61
Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med (2006) 6.58
Frailty consensus: a call to action. J Am Med Dir Assoc (2013) 6.54
Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study. J Am Geriatr Soc (2005) 6.54
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci (2005) 6.42
Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA (2012) 6.29
Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA (2007) 6.02
Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA (2008) 6.00
Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med (2002) 5.98
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
Validating administrative data in stroke research. Stroke (2002) 5.90
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med (2003) 5.87
Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation (2007) 5.87
Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med (2008) 5.86
Electronic medical records for genetic research: results of the eMERGE consortium. Sci Transl Med (2011) 5.82
Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc (2004) 5.80
Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg (2010) 5.72
Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation (2010) 5.70
Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA (2005) 5.46
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation (2009) 5.26
Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20
The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J Am Coll Cardiol (2008) 5.05
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med (2002) 4.97
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85
Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol (2010) 4.83
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA (2004) 4.73
Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation (2003) 4.67
Home use of automated external defibrillators for sudden cardiac arrest. N Engl J Med (2008) 4.64
Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med (2005) 4.57
Reporting genetic results in research studies: summary and recommendations of an NHLBI working group. Am J Med Genet A (2006) 4.56
Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc (2002) 4.55
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
Differences in life expectancy due to race and educational differences are widening, and many may not catch up. Health Aff (Millwood) (2012) 4.36
The 6-min walk test: a quick measure of functional status in elderly adults. Chest (2003) 4.29
Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care (2003) 4.23
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci (2002) 4.00
Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ (2009) 3.91
Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation (2007) 3.90
Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet (2002) 3.88
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet (2011) 3.85
Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation (2003) 3.76
Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis. Arch Intern Med (2008) 3.76
The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies. J Am Geriatr Soc (2005) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA (2012) 3.67
Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Ann Intern Med (2004) 3.66
Assuring the quality of next-generation sequencing in clinical laboratory practice. Nat Biotechnol (2012) 3.62
Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2007) 3.61
Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med (2005) 3.56
Rapid kidney function decline and mortality risk in older adults. Arch Intern Med (2008) 3.54
Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement. J Am Geriatr Soc (2004) 3.52
Limited literacy and mortality in the elderly: the health, aging, and body composition study. J Gen Intern Med (2006) 3.51
Thyroid status, cardiovascular risk, and mortality in older adults. JAMA (2006) 3.50
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet Epidemiol (2010) 3.48
Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr (2009) 3.44
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med (2005) 3.39
The clinical efficacy of magnetic resonance imaging in neuroimaging. Ann Intern Med (1994) 3.33
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc (2003) 3.30
Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc (2005) 3.29
Kidney function as a predictor of noncardiovascular mortality. J Am Soc Nephrol (2005) 3.28
A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. Arch Intern Med (2009) 3.27
Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke (2004) 3.26