Published in Pediatr Res on July 20, 2006
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A (2015) 0.94
The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem (2012) 0.81
Regulation of the microenvironment for cardiac tissue engineering. Regen Med (2017) 0.75
Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol (2005) 3.44
Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet (2003) 3.00
Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79
FlgM gains structure in living cells. Proc Natl Acad Sci U S A (2002) 2.46
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res (2004) 2.06
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol (2006) 2.06
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res (2007) 2.05
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest (2008) 2.02
Macromolecular crowding in the Escherichia coli periplasm maintains alpha-synuclein disorder. J Mol Biol (2005) 2.01
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem (2003) 1.99
Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.98
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I. J Biol Chem (2006) 1.89
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem (2003) 1.87
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. J Physiol (2003) 1.85
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol (2007) 1.84
Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis (2005) 1.83
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res (2003) 1.82
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem (2008) 1.75
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res (2007) 1.74
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem (2003) 1.73
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J (2007) 1.61
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol (2007) 1.60
Effects of proteins on protein diffusion. J Am Chem Soc (2010) 1.58
Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation (2006) 1.53
Differential dynamical effects of macromolecular crowding on an intrinsically disordered protein and a globular protein: implications for in-cell NMR spectroscopy. J Am Chem Soc (2008) 1.49
Protein crowding tunes protein stability. J Am Chem Soc (2011) 1.49
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circ Res (2007) 1.48
A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation. Physiology (Bethesda) (2007) 1.48
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol (2004) 1.48
RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J Virol (2003) 1.47
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I. J Biol Chem (2008) 1.46
Protein (19)F NMR in Escherichia coli. J Am Chem Soc (2010) 1.46
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol (2009) 1.46
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res (2012) 1.39
Impact of protein denaturants and stabilizers on water structure. J Am Chem Soc (2004) 1.39
Macromolecular crowding and protein stability. J Am Chem Soc (2012) 1.38
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J (2005) 1.38
The cellular environment stabilizes adenine riboswitch RNA structure. Biochemistry (2013) 1.38
Volume exclusion and soft interaction effects on protein stability under crowded conditions. Biochemistry (2010) 1.37
MicroRNAs can regulate human APP levels. Mol Neurodegener (2008) 1.34
Residue-level interrogation of macromolecular crowding effects on protein stability. J Am Chem Soc (2008) 1.33
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res (2009) 1.33
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res (2004) 1.32
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res (2007) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation (2010) 1.29
The significance of regulatory light chain phosphorylation in cardiac physiology. Arch Biochem Biophys (2011) 1.27
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. J Biol Chem (2012) 1.27
Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem (2004) 1.27
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res (2007) 1.26
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol (2006) 1.25
An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener (2007) 1.22
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci (2004) 1.22
Macromolecular crowding fails to fold a globular protein in cells. J Am Chem Soc (2011) 1.21
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol (2010) 1.21
In vivo selection for metastasis promoting genes in the mouse. Proc Natl Acad Sci U S A (2007) 1.20
Impact of reconstituted cytosol on protein stability. Proc Natl Acad Sci U S A (2013) 1.20
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts. Am J Physiol Heart Circ Physiol (2008) 1.20
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation (2010) 1.18
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation (2008) 1.17
Unexpected effects of macromolecular crowding on protein stability. Biochemistry (2012) 1.17
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol (2008) 1.16
Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. J Biol Chem (2008) 1.15
Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem (2007) 1.14
Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties. J Mol Cell Cardiol (2012) 1.14
Temperature-induced reversible conformational change in the first 100 residues of alpha-synuclein. Protein Sci (2006) 1.14
Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res (2005) 1.14
A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. J Biol Chem (2012) 1.12
Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovasc Res (2008) 1.12
In situ structural characterization of a recombinant protein in native Escherichia coli membranes with solid-state magic-angle-spinning NMR. J Am Chem Soc (2011) 1.11
RNA interference using boranophosphate siRNAs: structure-activity relationships. Nucleic Acids Res (2004) 1.11
Troponin I serines 43/45 and regulation of cardiac myofilament function. Am J Physiol Heart Circ Physiol (2002) 1.11
p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. Am J Physiol Regul Integr Comp Physiol (2007) 1.11
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol (2011) 1.10
Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex. Biochemistry (2003) 1.10
Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PLoS One (2011) 1.10
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
Retracted Protein dynamics in living cells. Biochemistry (2005) 1.10
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically. J Physiol (2004) 1.09
The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Mol Cell Biochem (2004) 1.08
Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction. Am J Physiol Heart Circ Physiol (2005) 1.08
Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments. J Biol Chem (2010) 1.08
Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice. J Biol Chem (2010) 1.07
Stability and apoptotic activity of recombinant human cytochrome c. Biochem Biophys Res Commun (2003) 1.06
Translational and rotational diffusion of a small globular protein under crowded conditions. J Phys Chem B (2009) 1.05
Barriers to HPV immunization for African American adolescent females. Vaccine (2012) 1.05
A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. Mol Cell Proteomics (2010) 1.05
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo. Am J Physiol Heart Circ Physiol (2004) 1.04
Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. J Biol Chem (2006) 1.04
Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy. Proteomics (2008) 1.04
19F NMR studies of alpha-synuclein conformation and fibrillation. Biochemistry (2009) 1.04
PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. Biochemistry (2007) 1.04
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. Am J Physiol Heart Circ Physiol (2002) 1.03
Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia. Circ Res (2005) 1.03
Infections diagnosed in the first year after pediatric stem cell transplantation. Pediatr Infect Dis J (2002) 1.03
Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circ Res (2002) 1.02
Using NMR to distinguish viscosity effects from nonspecific protein binding under crowded conditions. J Am Chem Soc (2009) 1.02