Published in Immunity on July 27, 2006
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med (2007) 2.37
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. Immunity (2009) 2.16
Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination. Immunity (2011) 2.12
How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol (2012) 1.80
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity (2007) 1.52
Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals. PLoS One (2016) 1.38
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest (2009) 1.37
A constant affinity threshold for T cell tolerance. J Exp Med (2007) 1.36
Insights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design. J Immunol (2011) 1.35
Signaling in thymic selection. Curr Opin Immunol (2011) 1.29
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery. Proc Natl Acad Sci U S A (2010) 1.28
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol (2009) 1.20
Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position. J Immunol (2009) 1.18
CD8 controls T cell cross-reactivity. J Immunol (2010) 1.15
Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity. Cancer Res (2015) 1.13
A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol (2009) 1.11
Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination. J Immunol (2013) 1.06
T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. Eur J Immunol (2007) 1.06
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol (2014) 1.02
NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation. PLoS One (2009) 1.01
Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model. J Immunol (2012) 0.98
A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change. J Immunol (2008) 0.97
The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol (2009) 0.96
The molecular determinants of CD8 co-receptor function. Immunology (2012) 0.94
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol (2008) 0.91
Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells. Proc Natl Acad Sci U S A (2012) 0.91
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression. Immunology (2010) 0.91
Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. J Immunol (2012) 0.90
Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling. PLoS One (2012) 0.88
Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Front Immunol (2013) 0.87
Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor. Nat Commun (2014) 0.84
CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep (2011) 0.83
Initiation of TCR phosphorylation and signal transduction. Front Immunol (2011) 0.81
A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection. J Recept Signal Transduct Res (2010) 0.81
Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8. J Immunol (2011) 0.80
Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanisms. J Immunol (2014) 0.80
Visualizing intermolecular interactions in T cells. Curr Top Microbiol Immunol (2009) 0.79
Gads regulates the expansion phase of CD8+ T cell-mediated immunity. J Immunol (2011) 0.78
Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol (2015) 0.76
Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse. Clin Dev Immunol (2013) 0.76
Visualization of Protein Interactions in Living Cells. Self Nonself (2011) 0.76
A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire. Cell Rep (2016) 0.75
The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. PLoS One (2013) 0.75
Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner. PLoS One (2017) 0.75
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05
Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J (2004) 3.41
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med (2009) 2.66
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85
CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A (2002) 1.70
Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity (2002) 1.69
Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A (2008) 1.54
Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci U S A (2012) 1.50
Body-barrier surveillance by epidermal γδ TCRs. Nat Immunol (2012) 1.48
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol (2002) 1.38
Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal (2009) 1.33
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature (2013) 1.21
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 1.19
Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J Immunol (2009) 1.16
Molecular interactions at the T cell-antigen-presenting cell interface. Curr Opin Immunol (2004) 1.15
T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol (2003) 1.05
The stabilization and targeting of surfactant-synthesized gold nanorods. Nanotechnology (2009) 1.03
Protein kinase C η is required for T cell activation and homeostatic proliferation. Sci Signal (2011) 1.00
A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol (2005) 0.99
Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Cell Res (2012) 0.99
Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun (2013) 0.97
Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol (2004) 0.95
Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. J Leukoc Biol (2005) 0.91
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol (2008) 0.91
Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. J Immunol (2003) 0.89
Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. J Immunol Methods (2009) 0.87
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest (2015) 0.86
Co-receptors and recognition of self at the immunological synapse. Curr Top Microbiol Immunol (2010) 0.84
CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep (2011) 0.83
Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83
Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides (2005) 0.83
Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64. Integr Biol (Camb) (2013) 0.82
Tespa1: another gatekeeper for positive selection. Nat Immunol (2012) 0.82
Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics (2003) 0.80
Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol (2004) 0.80
The role of protein kinase cη in T cell biology. Front Immunol (2012) 0.80
Visualizing intermolecular interactions in T cells. Curr Top Microbiol Immunol (2009) 0.79
Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells. Mol Immunol (2006) 0.79
In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness. PLoS One (2013) 0.79
Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers. PLoS One (2012) 0.78
Distinct footprints of TCR engagement with highly homologous ligands. J Immunol (2004) 0.77
Protein kinase Cη, an emerging player in T-cell biology. Cell Cycle (2012) 0.76
Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. J Clin Invest (2016) 0.75
Too fast to die. Sci Signal (2013) 0.75
A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions. PLoS One (2012) 0.75
CD8+ thymocyte differentiation: T cell two-step. Nat Immunol (2010) 0.75
Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells. Traffic (2006) 0.75
Binding kinetics of superantigen with TCR and MHC class II. Methods Mol Biol (2003) 0.75
Thymic origins of T cell receptor alloreactivity. Transplantation (2017) 0.75