CD8+ thymocyte differentiation: T cell two-step.

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98

CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med (2004) 2.52

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity (2008) 2.49

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol (2010) 2.19

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity (2000) 1.83

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity (1996) 1.83

CCR7 directs the migration of thymocytes into the thymic medulla. J Immunol (2004) 1.72

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J Exp Med (2003) 1.58

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol (2004) 1.57

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med (2006) 1.32

Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A (2009) 1.27

Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation. Immunity (2009) 1.20

Visualization and identification of IL-7 producing cells in reporter mice. PLoS One (2009) 1.11

Transcriptional regulation in helper versus cytotoxic-lineage decision. Curr Opin Immunol (2009) 0.96

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05

Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J (2004) 3.41

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12

TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A (2002) 1.70

Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity (2002) 1.69

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity (2006) 1.63

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol (2002) 1.38

Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal (2009) 1.33

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 1.19

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06

TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol (2003) 1.05

Protein kinase C η is required for T cell activation and homeostatic proliferation. Sci Signal (2011) 1.00

A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol (2005) 0.99

Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol (2004) 0.95

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol (2008) 0.91

Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. J Leukoc Biol (2005) 0.91

Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. J Immunol (2003) 0.89

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. J Immunol Methods (2009) 0.87

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83

CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep (2011) 0.83

Tespa1: another gatekeeper for positive selection. Nat Immunol (2012) 0.82

Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol (2004) 0.80

Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics (2003) 0.80

The role of protein kinase cη in T cell biology. Front Immunol (2012) 0.80

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness. PLoS One (2013) 0.79

Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells. Mol Immunol (2006) 0.79

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers. PLoS One (2012) 0.78

Distinct footprints of TCR engagement with highly homologous ligands. J Immunol (2004) 0.77

Protein kinase Cη, an emerging player in T-cell biology. Cell Cycle (2012) 0.76

Too fast to die. Sci Signal (2013) 0.75

Thymic origins of T cell receptor alloreactivity. Transplantation (2017) 0.75

Binding kinetics of superantigen with TCR and MHC class II. Methods Mol Biol (2003) 0.75

Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells. Traffic (2006) 0.75