Published in J Immunol on August 01, 2002
Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest (2004) 5.16
Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol (2012) 3.43
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol (2005) 3.12
Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med (2004) 2.94
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides. Proc Natl Acad Sci U S A (2005) 2.83
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med (2007) 2.37
Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J Clin Invest (2007) 1.83
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. J Immunol (2009) 1.81
CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med (2003) 1.63
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc Natl Acad Sci U S A (2004) 1.61
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2013) 1.60
Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A (2009) 1.57
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J Exp Med (2006) 1.56
Invariant NKT cells are required for airway inflammation induced by environmental antigens. J Exp Med (2011) 1.51
The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode. J Exp Med (2010) 1.50
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. J Exp Med (2006) 1.32
Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med (2007) 1.15
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med (2010) 1.11
NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. J Immunol (2011) 1.04
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity. J Clin Invest (2011) 1.03
Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells. Immunol Rev (2012) 0.99
Harnessing human CD1d restricted T cells for tumor immunity: progress and challenges. Front Biosci (Landmark Ed) (2009) 0.96
Optimizing NKT cell ligands as vaccine adjuvants. Immunotherapy (2014) 0.93
Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection. J Immunol (2013) 0.89
Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines (2008) 0.86
Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells. Ann N Y Acad Sci (2012) 0.82
Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics (2003) 0.80
The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells. ChemMedChem (2009) 0.80
Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Immunology (2003) 0.79
Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol (2016) 0.77
Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1d. ACS Med Chem Lett (2012) 0.76
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79
NKT cells: what's in a name? Nat Rev Immunol (2004) 7.84
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med (2003) 6.42
Recognition of bacterial glycosphingolipids by natural killer T cells. Nature (2005) 6.38
CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med (2006) 5.89
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51
Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci U S A (2002) 5.17
Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest (2004) 5.16
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol (2009) 4.76
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72
Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol (2002) 3.61
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (2013) 3.59
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol (2011) 3.48
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46
Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J (2004) 3.41
The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol (2007) 3.34
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25
How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20
Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol (2003) 2.95
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol (2007) 2.78
Homeostasis of V alpha 14i NKT cells. Nat Immunol (2002) 2.67
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron (2007) 2.54
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol (2003) 2.48
Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol (2007) 2.46
Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45
Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med (2002) 2.38
An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell (2013) 2.36
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A (2006) 2.34
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis (2008) 2.33
Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science (2005) 2.32
Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med (2003) 2.30
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A (2003) 2.28
Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27
Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27
Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J Immunol (2002) 2.26
Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol (2006) 2.18
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol (2010) 2.15
Antigen recognition determinants of gammadelta T cell receptors. Science (2005) 2.14
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A (2005) 2.13
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol (2005) 2.12
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology (2012) 2.11
Structure of the measles virus hemagglutinin. Nat Struct Mol Biol (2007) 2.11
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol (2013) 2.11
Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol (2003) 2.09
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature (2012) 2.08
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06
A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron (2005) 2.03
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity (2005) 2.03
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells. Chem Biol (2008) 1.95
TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol (2008) 1.90
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity (2011) 1.86
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides. Immunity (2002) 1.83
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. J Immunol (2009) 1.81
Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure (2010) 1.79
Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell (2007) 1.77
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A (2002) 1.73
Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology (2002) 1.72
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A (2005) 1.71
Specificity and degeneracy of T cells. Mol Immunol (2004) 1.71
CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A (2002) 1.70
Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity (2002) 1.69
Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (2008) 1.67
A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med (2008) 1.67
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc Natl Acad Sci U S A (2006) 1.66
Deconstructing the form and function of the TCR/CD3 complex. Immunity (2006) 1.64
Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63
The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63
CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med (2003) 1.63
Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity (2006) 1.63
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity (2009) 1.62
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc Natl Acad Sci U S A (2004) 1.61
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol (2005) 1.61
Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem Biol (2010) 1.60
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. Eur J Immunol (2003) 1.60
Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A (2009) 1.57
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med (2005) 1.57
Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med (2003) 1.56
Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus. J Clin Invest (2003) 1.55
BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expr Purif (2008) 1.53
The structure of interleukin-2 complexed with its alpha receptor. Science (2005) 1.53
Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med (2013) 1.53
Invariant NKT cells are required for airway inflammation induced by environmental antigens. J Exp Med (2011) 1.51