Published in PLoS One on September 16, 2013
Uncovering the PI3Ksome: phosphoinositide 3-kinases and counteracting PTEN form a signaling complex with intrinsic regulatory properties. Mol Cell Biol (2014) 0.75
In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal (2017) 0.75
Stochastic gene expression in a single cell. Science (2002) 34.54
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00
Biological robustness. Nat Rev Genet (2004) 9.98
Weak pairwise correlations imply strongly correlated network states in a neural population. Nature (2006) 9.18
Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32
Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol (2008) 7.43
Robustness of cellular functions. Cell (2004) 6.65
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Towards a theory of biological robustness. Mol Syst Biol (2007) 3.82
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta (1993) 3.77
Back in the water: the return of the inositol phosphates. Nat Rev Mol Cell Biol (2001) 3.69
Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science (2008) 3.38
Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev (2009) 3.35
BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains. Bioinformatics (2004) 3.32
Statistical mechanics for natural flocks of birds. Proc Natl Acad Sci U S A (2012) 3.23
Origins of extrinsic variability in eukaryotic gene expression. Nature (2005) 3.18
Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat Immunol (2002) 2.79
Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42
Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell (2012) 2.28
Pleckstrin homology domains: a common fold with diverse functions. Annu Rev Biophys Biomol Struct (1998) 2.06
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1. Cold Spring Harb Perspect Biol (2010) 1.95
Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem (2001) 1.81
PIP3, PIP2, and cell movement--similar messages, different meanings? Dev Cell (2001) 1.70
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A (2011) 1.54
Positive regulation of Itk PH domain function by soluble IP4. Science (2007) 1.52
Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem (1997) 1.52
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry (2004) 1.52
A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium. Mol Biol Cell (1998) 1.51
Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity (2004) 1.50
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med (2005) 1.49
T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol (2010) 1.45
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity (2007) 1.33
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med (2010) 1.32
Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta (2006) 1.32
Signaling in thymic selection. Curr Opin Immunol (2011) 1.29
Modeling cell signaling networks. Biol Cell (2004) 1.21
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A (2004) 1.20
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate. Nat Rev Immunol (2010) 1.17
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development. Nat Immunol (2003) 1.16
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med (2010) 1.12
The cell in an era of systems biology. Cell (2011) 1.12
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A (2011) 1.09
Lipid signaling in T-cell development and function. Cold Spring Harb Perspect Biol (2010) 1.08
T-cell receptor affinity in thymic development. Immunology (2012) 0.99
Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors. J Biol Chem (2006) 0.98
Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk. J Mol Biol (2003) 0.98
Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain. J Mol Biol (2009) 0.96
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Sci Signal (2010) 0.91
Stochastic noise and synchronisation during dictyostelium aggregation make cAMP oscillations robust. PLoS Comput Biol (2007) 0.90
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A (2008) 0.89
Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling. Cell Mol Life Sci (2010) 0.88
Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol (2010) 0.84
The Tec family kinase Itk exists as a folded monomer in vivo. J Biol Chem (2009) 0.83
Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling. Blood (2012) 0.82
Cell signaling. The art of the soluble. Science (2007) 0.80
Pleckstrin homology domains of tec family protein kinases. Biochem Biophys Res Commun (1999) 0.78
Stochastic population mechanics in the relational systems formalism: Volterra-Lotka ecological dynamics. J Theor Biol (1970) 0.77
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05
IL-21 is required to control chronic viral infection. Science (2009) 4.80
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J (2004) 3.41
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16
The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity (2008) 2.13
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity (2009) 1.94
TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am J Psychiatry (2009) 1.85
A major susceptibility locus for specific language impairment is located on 13q21. Am J Hum Genet (2002) 1.79
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A (2002) 1.70
Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity (2002) 1.69
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene. Am J Med Genet B Neuropsychiatr Genet (2005) 1.64
Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity (2006) 1.63
Positive regulation of Itk PH domain function by soluble IP4. Science (2007) 1.52
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity (2007) 1.52
HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity. Am J Hum Genet (2002) 1.51
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44
Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci U S A (2007) 1.43
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities. Proc Natl Acad Sci U S A (2007) 1.42
Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A (2008) 1.41
Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Hum Hered (2004) 1.38
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol (2002) 1.38
Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal (2009) 1.33
Mechanisms of drug resistance in kinases. Expert Opin Investig Drugs (2011) 1.29
Evaluation of FOXP2 as an autism susceptibility gene. Am J Med Genet (2002) 1.25
Pairing computation with experimentation: a powerful coupling for understanding T cell signalling. Nat Rev Immunol (2010) 1.25
The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker. Hum Hered (2005) 1.24
KELVIN: a software package for rigorous measurement of statistical evidence in human genetics. Hum Hered (2011) 1.23
Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage. Genet Epidemiol (2007) 1.21
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A (2004) 1.20
Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7. Am J Med Genet B Neuropsychiatr Genet (2003) 1.20
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 1.19
Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nat Immunol (2007) 1.13
Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. J Immunol (2003) 1.13
SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. J Clin Endocrinol Metab (2013) 1.12
Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. J Biol Chem (2010) 1.09
Lipid signaling in T-cell development and function. Cold Spring Harb Perspect Biol (2010) 1.08
Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability. J Med Genet (2010) 1.06
T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
Multivariate analysis of surface water quality in the Three Gorges area of China and implications for water management. J Environ Sci (China) (2011) 1.05
TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol (2003) 1.05
A new method for computing the multipoint posterior probability of linkage. Hum Hered (2004) 1.02
Protein kinase C η is required for T cell activation and homeostatic proliferation. Sci Signal (2011) 1.00
A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol (2005) 0.99
The emperor's new methods. Am J Hum Genet (2003) 0.99
Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data set. Am J Hum Genet (2005) 0.98
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Mol Cell (2009) 0.96
Association statistics under the PPL framework. Genet Epidemiol (2010) 0.95
Exploiting gene x gene interaction in linkage analysis. BMC Proc (2007) 0.95
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest (2012) 0.95
Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol (2004) 0.95
Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families. BMC Genet (2005) 0.94
Expected monotonicity--a desirable property for evidence measures? Hum Hered (2010) 0.94
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol (2008) 0.91
Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. J Leukoc Biol (2005) 0.91
Fast and accurate calculation of a computationally intensive statistic for mapping disease genes. J Comput Biol (2009) 0.91
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. J Allergy Clin Immunol (2009) 0.91
Balancing pro- and anti-inflammatory TLR4 signaling. Nat Immunol (2012) 0.90
The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal (2013) 0.89
A case of autism and uniparental disomy of chromosome 1. Hum Genet (2005) 0.89
Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. J Immunol (2003) 0.89
Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci. BMC Proc (2007) 0.89
Host-to-host variation of ecological interactions in polymicrobial infections. Phys Biol (2014) 0.88
Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal (2009) 0.87
The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPL. Hum Hered (2006) 0.87
Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. J Immunol Methods (2009) 0.87
New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B. Expert Opin Ther Targets (2008) 0.87
Large cargo transport by nuclear pores: implications for the spatial organization of FG-nucleoporins. EMBO J (2013) 0.86
Employing MCMC under the PPL framework to analyze sequence data in large pedigrees. Front Genet (2013) 0.85
Interaction between single molecules of Mac-1 and ICAM-1 in living cells: an atomic force microscopy study. Exp Cell Res (2007) 0.83
CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep (2011) 0.83
Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83
Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals. Eur J Immunol (2014) 0.82
Choreography of importin-α/CAS complex assembly and disassembly at nuclear pores. Proc Natl Acad Sci U S A (2013) 0.82
Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genet Epidemiol (2007) 0.82
Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling. Blood (2012) 0.82
Tespa1: another gatekeeper for positive selection. Nat Immunol (2012) 0.82
Combined linkage and linkage disequilibrium analysis of a motor speech phenotype within families ascertained for autism risk loci. J Neurodev Disord (2010) 0.81
A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. J Immunol (2009) 0.81
Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. Biochemistry (2005) 0.81
Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics (2003) 0.80