Cell signaling and neuronal death.

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron (2008) 3.46

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat Rev Neurosci (2007) 2.79

Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol Neurobiol (2008) 1.93

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proc Natl Acad Sci U S A (2012) 1.30

The bright side of being blue: depression as an adaptation for analyzing complex problems. Psychol Rev (2009) 1.28

Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor. J Biol Chem (2010) 1.18

Glutathione in cancer cell death. Cancers (Basel) (2011) 1.15

Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. J Neurosci (2008) 1.13

Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. Am J Physiol Renal Physiol (2010) 1.13

Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain (2010) 1.10

Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci (2010) 1.10

Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways. Exp Neurol (2009) 1.07

Calcium-induced calcium release contributes to synaptic release from mouse rod photoreceptors. Neuroscience (2009) 1.07

Endoplasmic reticulum Ca2+ dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na+-K+-Cl- cotransporter. J Neurochem (2008) 1.06

CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04

Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice. Brain Res (2009) 1.01

Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. J Neurosci Res (2008) 1.00

Motor neuron trophic factors: therapeutic use in ALS? Brain Res Rev (2010) 0.98

Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo. Graefes Arch Clin Exp Ophthalmol (2009) 0.98

The role of glutamate in neuronal ischemic injury: the role of spark in fire. Neurol Sci (2011) 0.97

Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One (2009) 0.96

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity. BMC Neurosci (2008) 0.96

Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies. J Neurosci Res (2008) 0.94

Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection. J Neuroinflammation (2008) 0.93

S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep (2014) 0.91

Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes. J Neurochem (2011) 0.91

Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity. J Neurosci (2013) 0.90

Role of calpain in apoptosis. Cell J (2011) 0.89

Neuroprotection in glaucoma. Indian J Ophthalmol (2011) 0.88

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases. Oxid Med Cell Longev (2015) 0.87

The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism. Hippocampus (2011) 0.87

Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. J Bioenerg Biomembr (2008) 0.87

NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice. Psychopharmacology (Berl) (2012) 0.87

Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. J Cereb Blood Flow Metab (2013) 0.86

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function. J Biol Chem (2012) 0.86

Therapeutic approaches to preventing cell death in Huntington disease. Prog Neurobiol (2012) 0.84

A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma. J Biol Chem (2012) 0.84

Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. J Cell Biol (2008) 0.82

Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk. Neurosci Res (2009) 0.82

NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test. Psychopharmacology (Berl) (2009) 0.81

Glutamate-induced post-activation inhibition of locus coeruleus neurons is mediated by AMPA/kainate receptors and sodium-dependent potassium currents. Br J Pharmacol (2009) 0.81

Hyperglycaemia and apoptosis of microglial cells in human septic shock. Crit Care (2011) 0.81

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Res (2014) 0.81

Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage. Mol Brain (2014) 0.80

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system. Mol Neurodegener (2012) 0.80

Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79

Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke. Cell Mol Neurobiol (2015) 0.78

Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line. J Mol Neurosci (2010) 0.78

Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain. Inflammopharmacology (2014) 0.78

SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci (2015) 0.78

Exacerbation of apoptosis of cortical neurons following traumatic brain injury in par-4 transgenic mice. Int J Clin Exp Pathol (2008) 0.78

Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential. ASN Neuro (2015) 0.77

Effects of embryonic cyclosporine exposures on brain development and behavior. Behav Brain Res (2015) 0.77

Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau. Brain Res (2008) 0.77

The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plast (2016) 0.77

Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke. J Rehabil Res Dev (2008) 0.77

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Rep (2016) 0.77

Eszopiclone prevents excitotoxicity and neurodegeneration in the hippocampus induced by experimental apnea. Sleep (2009) 0.77

The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY) (2015) 0.76

Live imaging of endogenous Ca(2+) /calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity. J Neurochem (2015) 0.76

Ischemia-reperfusion model in rat spinal cord: cell viability and apoptosis signaling study. Int J Clin Exp Pathol (2015) 0.75

Herbal formula GAPT prevents beta amyloid deposition induced Ca(2+)/Calmodulin-dependent protein kinase II and Ca(2+)/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice. BMC Complement Altern Med (2016) 0.75

Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo. Neurochem Int (2015) 0.75

SCYL pseudokinases in neuronal function and survival. Neural Regen Res (2016) 0.75

Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout. Sci Rep (2016) 0.75

The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci (2016) 0.75

The mu opioid receptor activation does not affect ischemia-induced agonal currents in rat spinal ventral horn. J Anesth (2014) 0.75

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28

H2S signals through protein S-sulfhydration. Sci Signal (2009) 4.54

Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A (2002) 4.38

Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics (2004) 3.54

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34

Phosphorylation of proteins by inositol pyrophosphates. Science (2004) 3.27

Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell (2012) 3.26

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science (2005) 3.05

Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem (2004) 2.95

Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res (2011) 2.94

Novel neural modulators. Annu Rev Neurosci (2003) 2.91

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79

Signaling by gasotransmitters. Sci Signal (2009) 2.66

H₂S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol (2012) 2.59

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science (2009) 2.39

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31

Hydrogen sulfide as a gasotransmitter. J Neurochem (2010) 2.30

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab (2011) 2.24

GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22

Schizophrenia: diverse approaches to a complex disease. Science (2002) 2.20

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17

PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06

H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A (2010) 2.04

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03

Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A (2009) 1.96

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2002) 1.96

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science (2006) 1.95

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94

Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92

GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83

NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83

Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol (2012) 1.79

Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci U S A (2002) 1.76

Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol Neurobiol (2006) 1.75

A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell (2006) 1.75

Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proc Natl Acad Sci U S A (2005) 1.75

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nat Neurosci (2011) 1.74

From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74

S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron (2005) 1.73

Akt as a mediator of cell death. Proc Natl Acad Sci U S A (2003) 1.73

Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71

Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A (2002) 1.69

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68

Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A (2006) 1.66

Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem (2004) 1.63

D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc Natl Acad Sci U S A (2003) 1.57

Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci (2013) 1.55

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A (2012) 1.50

Sulfhydration mediates neuroprotective actions of parkin. Nat Commun (2013) 1.49

PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem (2004) 1.47

Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A (2008) 1.46

A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A (2005) 1.42

Heme oxygenase-2 is activated by calcium-calmodulin. J Biol Chem (2004) 1.41

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2008) 1.39

Inositol pyrophosphates as mammalian cell signals. Sci Signal (2011) 1.38

S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron (2011) 1.35

Hydrogen sulfide: a gasotransmitter of clinical relevance. J Mol Med (Berl) (2012) 1.29

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A (2011) 1.27

Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc Natl Acad Sci U S A (2002) 1.27

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci U S A (2007) 1.27

Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry (2002) 1.25

Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. Chem Biol (2008) 1.24

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proc Natl Acad Sci U S A (2005) 1.24

Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron (2011) 1.21

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2010) 1.20

Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron (2003) 1.20

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc Natl Acad Sci U S A (2006) 1.20

Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. J Biol Chem (2010) 1.19

Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol (2011) 1.15

S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity. Proc Natl Acad Sci U S A (2008) 1.13

RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release. Proc Natl Acad Sci U S A (2004) 1.13

Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci (2005) 1.13

Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A (2014) 1.13

Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci (2010) 1.10

Genetics. Two genes link two distinct psychoses. Science (2005) 1.09

Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2006) 1.09

Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Proc Natl Acad Sci U S A (2009) 1.09

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts. Neurobiol Dis (2005) 1.08

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport (2004) 1.08

Regulation of AMPA receptor localization in lipid rafts. Mol Cell Neurosci (2008) 1.07

Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal (2013) 1.06

Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis. Proc Natl Acad Sci U S A (2010) 1.06

Protein modifications involved in neurotransmitter and gasotransmitter signaling. Trends Neurosci (2010) 1.06

Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation. Proc Natl Acad Sci U S A (2011) 1.04

S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. Proc Natl Acad Sci U S A (2009) 1.04

Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally derived NADH. Proc Natl Acad Sci U S A (2005) 1.03

UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. J Biol Chem (2002) 1.02

Apoptosis and calcium: new roles for cytochrome c and inositol 1,4,5-trisphosphate. Cell Cycle (2004) 1.00

Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition. Proc Natl Acad Sci U S A (2004) 0.99

Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum). Neuropharmacology (2010) 0.99

Modulation of D-serine levels in brains of mice lacking PICK1. Biol Psychiatry (2008) 0.98

Schizophrenia: neural mechanisms for novel therapies. Mol Med (2003) 0.98

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc Natl Acad Sci U S A (2002) 0.98

Messenger molecules and cell death: therapeutic implications. JAMA (2006) 0.98

Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. Chem Biol (2002) 0.98

PIKE GTPase: a novel mediator of phosphoinositide signaling. J Cell Sci (2004) 0.98