Published in Science on November 18, 2005
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A (2007) 3.02
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89
An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia. Am J Psychiatry (2008) 2.53
Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophr Bull (2009) 1.44
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev (2010) 1.24
DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull (2010) 1.04
NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. J Neurosci (2009) 1.04
Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings. Schizophr Bull (2006) 0.91
Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem (2011) 0.89
Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder. Cell Mol Neurobiol (2007) 0.87
DISC1 as a therapeutic target for mental illnesses. Expert Opin Ther Targets (2012) 0.87
PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis. Transl Psychiatry (2012) 0.86
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Transl Psychiatry (2013) 0.85
Genetic association of cyclic AMP signaling genes with bipolar disorder. Transl Psychiatry (2012) 0.81
Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet (2014) 0.80
Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia. Schizophr Res (2013) 0.80
Schizophrenia: A point of disruption. Nature (2009) 0.75
Disordered ripples are a common feature of genetically distinct mouse models relevant to schizophrenia. Mol Neuropsychiatry (2015) 0.75
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28
H2S signals through protein S-sulfhydration. Sci Signal (2009) 4.54
Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A (2002) 4.38
Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics (2004) 3.54
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34
Phosphorylation of proteins by inositol pyrophosphates. Science (2004) 3.27
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell (2012) 3.26
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science (2005) 3.05
Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem (2004) 2.95
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res (2011) 2.94
Novel neural modulators. Annu Rev Neurosci (2003) 2.91
Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79
Signaling by gasotransmitters. Sci Signal (2009) 2.66
H₂S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol (2012) 2.59
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science (2009) 2.39
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31
Hydrogen sulfide as a gasotransmitter. J Neurochem (2010) 2.30
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab (2011) 2.24
GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22
Schizophrenia: diverse approaches to a complex disease. Science (2002) 2.20
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A (2010) 2.04
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A (2009) 1.96
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2002) 1.96
Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science (2006) 1.95
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83
Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol (2012) 1.79
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci U S A (2002) 1.76
Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol Neurobiol (2006) 1.75
Cell signaling and neuronal death. Annu Rev Pharmacol Toxicol (2007) 1.75
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell (2006) 1.75
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proc Natl Acad Sci U S A (2005) 1.75
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nat Neurosci (2011) 1.74
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74
S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron (2005) 1.73
Akt as a mediator of cell death. Proc Natl Acad Sci U S A (2003) 1.73
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A (2002) 1.69
Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68
Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A (2006) 1.66
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem (2004) 1.63
D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc Natl Acad Sci U S A (2003) 1.57
Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci (2013) 1.55
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A (2012) 1.50
Sulfhydration mediates neuroprotective actions of parkin. Nat Commun (2013) 1.49
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem (2004) 1.47
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A (2008) 1.46
A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A (2005) 1.42
Heme oxygenase-2 is activated by calcium-calmodulin. J Biol Chem (2004) 1.41
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2008) 1.39
Inositol pyrophosphates as mammalian cell signals. Sci Signal (2011) 1.38
S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron (2011) 1.35
Hydrogen sulfide: a gasotransmitter of clinical relevance. J Mol Med (Berl) (2012) 1.29
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A (2011) 1.27
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc Natl Acad Sci U S A (2002) 1.27
Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci U S A (2007) 1.27
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry (2002) 1.25
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. Chem Biol (2008) 1.24
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proc Natl Acad Sci U S A (2005) 1.24
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron (2011) 1.21
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc Natl Acad Sci U S A (2006) 1.20
Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron (2003) 1.20
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2010) 1.20
Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. J Biol Chem (2010) 1.19
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol (2011) 1.15
RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release. Proc Natl Acad Sci U S A (2004) 1.13
S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity. Proc Natl Acad Sci U S A (2008) 1.13
Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci (2005) 1.13
Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A (2014) 1.13
Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci (2010) 1.10
Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2006) 1.09
Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Proc Natl Acad Sci U S A (2009) 1.09
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts. Neurobiol Dis (2005) 1.08
Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport (2004) 1.08
Regulation of AMPA receptor localization in lipid rafts. Mol Cell Neurosci (2008) 1.07
Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal (2013) 1.06
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis. Proc Natl Acad Sci U S A (2010) 1.06
Protein modifications involved in neurotransmitter and gasotransmitter signaling. Trends Neurosci (2010) 1.06
Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation. Proc Natl Acad Sci U S A (2011) 1.04
S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. Proc Natl Acad Sci U S A (2009) 1.04
Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally derived NADH. Proc Natl Acad Sci U S A (2005) 1.03
UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. J Biol Chem (2002) 1.02
Apoptosis and calcium: new roles for cytochrome c and inositol 1,4,5-trisphosphate. Cell Cycle (2004) 1.00
Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition. Proc Natl Acad Sci U S A (2004) 0.99
Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum). Neuropharmacology (2010) 0.99
Modulation of D-serine levels in brains of mice lacking PICK1. Biol Psychiatry (2008) 0.98
Schizophrenia: neural mechanisms for novel therapies. Mol Med (2003) 0.98
Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. Chem Biol (2002) 0.98
Messenger molecules and cell death: therapeutic implications. JAMA (2006) 0.98
Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc Natl Acad Sci U S A (2002) 0.98
PIKE GTPase: a novel mediator of phosphoinositide signaling. J Cell Sci (2004) 0.98