Published in Proc Natl Acad Sci U S A on January 26, 2010
Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol (2010) 1.54
Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci (2010) 1.39
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun (2013) 1.35
Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure. PLoS One (2014) 0.95
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes. J Biol Chem (2012) 0.90
Physiological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica neurons. J Neurophysiol (2011) 0.87
D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems. Amino Acids (2012) 0.87
Synthesis, accumulation, and release of d-aspartate in the Aplysia californica CNS. J Neurochem (2010) 0.85
Hydrogen sulfide and polysulfides as signaling molecules. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.85
A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the Aplysia californica central nervous system. J Biol Chem (2011) 0.82
Regulation of adult neurogenesis in the hippocampus by stress, acetylcholine and dopamine. J Nat Sci Biol Med (2011) 0.81
Production of hydrogen sulfide from d-cysteine and its therapeutic potential. Front Endocrinol (Lausanne) (2013) 0.80
Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals. Transl Psychiatry (2014) 0.80
D-serine increases adult hippocampal neurogenesis. Front Neurosci (2013) 0.78
Metabolic profiling of somatic tissues from Monochamus alternatus (Coleoptera: Cerambycidae) reveals effects of irradiation on metabolism. Int J Mol Sci (2014) 0.77
Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase? Amino Acids (2014) 0.76
D-Amino Acids in the Nervous and Endocrine Systems. Scientifica (Cairo) (2016) 0.75
Analysis of the Enantioselective Effects of PCB95 in Zebrafish (Danio rerio) Embryos through Targeted Metabolomics by UPLC-MS/MS. PLoS One (2016) 0.75
The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine. Curr Top Med Chem (2016) 0.75
d-Amino Acid Levels in Perfused Mouse Brain Tissue and Blood: A Comparative Study. ACS Chem Neurosci (2017) 0.75
D-Alanine in the islets of Langerhans of rat pancreas. Biochem Biophys Res Commun (2014) 0.75
Characterization of chiral amino acids from different milk origins using ultra-performance liquid chromatography coupled to ion-mobility mass spectrometry. Sci Rep (2017) 0.75
D-Glutamate is metabolized in the heart mitochondria. Sci Rep (2017) 0.75
Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50
Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci (2005) 8.96
GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature (2005) 7.04
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell (2006) 4.53
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature (2006) 4.01
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron (2009) 2.72
D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry (1998) 2.36
Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proc Natl Acad Sci U S A (2003) 2.35
Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol Rev (1998) 2.28
Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde. J Chromatogr (1992) 1.91
G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol (2007) 1.56
The presence of free D-aspartic acid in rodents and man. Biochem Biophys Res Commun (1986) 1.46
D-aspartate localizations imply neuronal and neuroendocrine roles. Proc Natl Acad Sci U S A (1997) 1.31
Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci (1996) 1.28
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. J Neurosci (2008) 1.27
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet (2009) 1.18
Properties of aspartate racemase, a pyridoxal 5'-phosphate-independent amino acid racemase. J Biol Chem (1992) 1.08
Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Neurosci Lett (1993) 1.08
Serine racemase binds to PICK1: potential relevance to schizophrenia. Mol Psychiatry (2006) 1.08
D-aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release. Neuroscience (2000) 1.05
Localization of D-aspartic acid in elongate spermatids in rat testis. Arch Biochem Biophys (1998) 0.94
Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase. J Biol Chem (1997) 0.91
Mechanism of racemization of amino acids by aspartate aminotransferase. Eur J Biochem (1992) 0.90
Occurrence of D-Amino Acids and a pyridoxal 5'-phosphate-dependent aspartate racemase in the acidothermophilic archaeon, Thermoplasma acidophilum. Biochem Biophys Res Commun (2001) 0.89
D-aspartate localization in the rat pituitary gland and retina. Brain Res (1999) 0.81
Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity. Eur J Biochem (1995) 0.80
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci (2005) 8.96
Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron (2011) 8.06
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature (2005) 7.04
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron (2007) 5.31
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
H2S signals through protein S-sulfhydration. Sci Signal (2009) 4.54
Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A (2002) 4.38
Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics (2004) 3.54
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell (2011) 3.47
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34
Phosphorylation of proteins by inositol pyrophosphates. Science (2004) 3.27
Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci (2011) 3.27
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell (2012) 3.26
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science (2005) 3.05
Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem (2004) 2.95
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res (2011) 2.94
Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol (2004) 2.94
Novel neural modulators. Annu Rev Neurosci (2003) 2.91
Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron (2009) 2.72
Signaling by gasotransmitters. Sci Signal (2009) 2.66
H₂S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol (2012) 2.59
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science (2009) 2.39
Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci (2010) 2.39
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31
Hydrogen sulfide as a gasotransmitter. J Neurochem (2010) 2.30
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab (2011) 2.24
GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci (2006) 2.23
GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22
Schizophrenia: diverse approaches to a complex disease. Science (2002) 2.20
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J Neurosci (2005) 2.06
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A (2010) 2.04
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
Development of neural stem cell in the adult brain. Curr Opin Neurobiol (2008) 2.02
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A (2009) 1.96
GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci (2009) 1.96
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2002) 1.96
Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science (2006) 1.95
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A (2008) 1.90
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev (2006) 1.88
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83
Synaptic integration and plasticity of new neurons in the adult hippocampus. J Physiol (2008) 1.82
The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials (2008) 1.82
Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol (2012) 1.79
Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci (2013) 1.78
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci U S A (2002) 1.76
Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol Neurobiol (2006) 1.75
Cell signaling and neuronal death. Annu Rev Pharmacol Toxicol (2007) 1.75
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell (2006) 1.75
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proc Natl Acad Sci U S A (2005) 1.75
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nat Neurosci (2011) 1.74
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74
S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron (2005) 1.73
Akt as a mediator of cell death. Proc Natl Acad Sci U S A (2003) 1.73
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A (2002) 1.69
Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68
G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res (2011) 1.67
BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66
Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A (2006) 1.66
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron (2013) 1.64
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem (2004) 1.63
DNA methylation presents distinct binding sites for human transcription factors. Elife (2013) 1.63
D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc Natl Acad Sci U S A (2003) 1.57