PubRank

Takehiko Sasaki

Author PubWeight™ 99.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002 4.35
2 Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 2006 4.09
3 Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004 3.92
4 Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol 2006 3.19
5 PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol 2006 3.12
6 Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science 2009 2.23
7 The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 2005 2.18
8 Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 2003 2.16
9 DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol 2006 1.86
10 Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 2007 1.86
11 A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A 2008 1.85
12 Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 2004 1.81
13 Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 2002 1.77
14 Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 2003 1.75
15 CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 2007 1.60
16 Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med 2011 1.52
17 MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol 2004 1.51
18 Portrait of PTEN: messages from mutant mice. Cancer Sci 2008 1.44
19 Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol 2009 1.39
20 Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003 1.36
21 Physiological functions of Pten in mouse tissues. Cell Struct Funct 2003 1.36
22 Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol 2003 1.34
23 Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest 2008 1.33
24 Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res 2006 1.29
25 CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med 2012 1.28
26 Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med 2012 1.23
27 Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med 2005 1.22
28 The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 2010 1.21
29 Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res 2008 1.19
30 Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest 2012 1.16
31 Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation. J Neurosci 2007 1.14
32 Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol 2006 1.12
33 Dynamics of human erythroblast enucleation. Int J Hematol 2008 1.11
34 Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol 2009 1.11
35 Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem 2003 1.11
36 Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem 2013 1.10
37 JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem 2003 1.09
38 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc Natl Acad Sci U S A 2012 1.07
39 IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts. Bone 2008 1.07
40 Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J Neurochem 2004 1.06
41 The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS One 2011 1.05
42 Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem 2002 1.04
43 Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A 2008 1.02
44 Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem 2010 1.01
45 The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood 2006 1.00
46 Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol 2008 1.00
47 Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J Immunol 2008 1.00
48 Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol Res 2006 0.99
49 A new PICTure of nucleolar stress. Cancer Sci 2012 0.98
50 Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation. FEBS Lett 2003 0.95
51 Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. J Bone Miner Res 2012 0.95
52 Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun 2012 0.93
53 Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A 2013 0.91
54 CD45 regulated signaling pathways. Curr Top Med Chem 2003 0.90
55 LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell 2012 0.90
56 Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J Biol Chem 2012 0.90
57 SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J 2003 0.89
58 Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A 2011 0.88
59 Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 2008 0.88
60 Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells. J Biol Chem 2004 0.88
61 LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J Lipid Res 2011 0.86
62 Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet 2012 0.84
63 Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem 2002 0.84
64 Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol Res 2009 0.84
65 Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood 2007 0.84
66 Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions. J Biochem 2013 0.81
67 Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology 2006 0.81
68 The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation. Int Arch Allergy Immunol 2010 0.81
69 5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration. Chembiochem 2010 0.80
70 Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression. Endocr Relat Cancer 2013 0.78
71 Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PLoS One 2011 0.78
72 Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J Gastroenterol Hepatol 2011 0.78
73 Assessment of the anatomical relationship between the arcuate eminence and superior semicircular canal by computed tomography. Neurol Med Chir (Tokyo) 2007 0.78
74 Alternative selective oxidation pathways for aldehyde oxidation and alkene epoxidation on a SiO2-supported Ru-monomer complex catalyst. J Am Chem Soc 2010 0.77
75 Oxide surface-promoted Pd-complex catalysis for intramolecular O-activated alkene hydroamination: catalyst preparation, characterization, and performance. Chem Commun (Camb) 2004 0.77
76 Selective oxidation of benzene to phenol with molecular oxygen on rhenium/zeolite catalysts. Chem Commun (Camb) 2004 0.76
77 Gamma knife radiosurgery for skull-base meningiomas. Prog Neurol Surg 2009 0.76
78 Density functional theoretical calculations for a Co2/gamma-Al2O3 model catalyst: structures of the gamma-Al2O3 bulk and surface and attachment sites for Co2+ ions. J Phys Chem B 2006 0.75
79 [Surgical outcome of external decompression associated with anterior and medial temporal lobectomy for massive hemispheric infarction due to internal carotid artery occlusion]. No Shinkei Geka 2010 0.75
80 [Phosphoinositides in membrane traffic]. Tanpakushitsu Kakusan Koso 2008 0.75
81 Surface-assisted transfer hydrogenation catalysis on a γ-Al2O3-supported Ir dimer. Phys Chem Chem Phys 2012 0.75
82 Photoinduced reversible structural transformation and selective oxidation catalysis of unsaturated ruthenium complexes supported on SiO2. Angew Chem Int Ed Engl 2008 0.75
83 Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis. FEBS J 2011 0.75
84 [Carotid endarterectomy preceding distal plaque-end dissection followed by internal shunt insertion: a case report]. No Shinkei Geka 2010 0.75
85 Simple landmark for preservation of the cochlea during maximum drilling of the petrous apex through the anterior transpetrosal approach. Neurol Med Chir (Tokyo) 2010 0.75
86 Co(OH)3 nanobelts: synthesis, characterization and shape-preserved transformation to pseudo-single-crystalline Co3O4 nanobelts. Nanotechnology 2009 0.75
87 Cu nanoclusters supported on nanocrystalline SiO₂-MnO₂: a bifunctional catalyst for the one-step conversion of glycerol to acrylic acid. Chem Commun (Camb) 2014 0.75
88 [Role of PTEN tumor suppressor gene in disease: PTEN-deficient mice]. Seikagaku 2008 0.75
89 Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L. Bioorg Med Chem 2008 0.75
90 Direct phenol synthesis by selective oxidation of benzene with molecular oxygen on an interstitial-N/Re cluster/zeolite catalyst. Angew Chem Int Ed Engl 2006 0.75