Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.

PubWeight™: 3.13‹?› | Rank: Top 1%

🔗 View Article (PMID 16905561)

Published in Hum Mol Genet on August 11, 2006

Authors

Lisa F Barcellos1, Stephen Sawcer, Patricia P Ramsay, Sergio E Baranzini, Glenys Thomson, Farren Briggs, Bruce C A Cree, Ann B Begovich, Pablo Villoslada, Xavier Montalban, Antonio Uccelli, Giovanni Savettieri, Robin R Lincoln, Carolyn DeLoa, Jonathan L Haines, Margaret A Pericak-Vance, Alastair Compston, Stephen L Hauser, Jorge R Oksenberg

Author Affiliations

1: Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, UK. barcello@genepi.berkeley.edu

Articles citing this

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16

Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. Am J Hum Genet (2010) 2.64

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31

HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology (2010) 2.29

HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS One (2007) 2.05

A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99

Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol (2011) 1.86

Human MHC architecture and evolution: implications for disease association studies. Int J Immunogenet (2008) 1.70

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A (2009) 1.69

The complex genetics of multiple sclerosis: pitfalls and prospects. Brain (2008) 1.68

Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis. J Neurol Sci (2010) 1.59

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 1.55

The inheritance of resistance alleles in multiple sclerosis. PLoS Genet (2007) 1.54

A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PLoS One (2010) 1.38

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain (2008) 1.37

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol (2009) 1.10

HLA-class I markers and multiple sclerosis susceptibility in the Italian population. Genes Immun (2009) 1.09

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun (2011) 1.08

Genetics and pathogenesis of multiple sclerosis. Semin Immunol (2009) 1.06

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med (2011) 1.06

Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms. Int J Mol Sci (2012) 1.04

The immunogenetics of multiple sclerosis. Immunogenetics (2008) 1.04

The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun (2015) 1.04

From genes to function: the next challenge to understanding multiple sclerosis. Nat Rev Immunol (2009) 1.01

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet (2010) 1.01

Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia. PLoS One (2009) 1.00

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet (2016) 0.97

Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice. J Autoimmun (2011) 0.96

Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract (2014) 0.96

HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma. J Immunol (2008) 0.95

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies. Blood (2014) 0.94

A functional variant in ERAP1 predisposes to multiple sclerosis. PLoS One (2012) 0.93

Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol (2010) 0.93

Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet (2010) 0.93

Evidence for more than one Parkinson's disease-associated variant within the HLA region. PLoS One (2011) 0.92

Multiple sclerosis: major histocompatibility complexity and antigen presentation. Genome Med (2009) 0.92

Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. PLoS One (2013) 0.92

Heterogeneity in multiple sclerosis: scratching the surface of a complex disease. Autoimmune Dis (2010) 0.92

Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet (2015) 0.90

Epistasis and immunity: the role of genetic interactions in autoimmune diseases. Immunology (2012) 0.90

Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populations. PLoS One (2012) 0.90

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet (2016) 0.90

An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene. BMC Med Genet (2009) 0.90

TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. PLoS One (2011) 0.86

Nonparametric methods for molecular biology. Methods Mol Biol (2010) 0.85

HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J Immunol (2009) 0.85

Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS One (2010) 0.85

HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia. PLoS One (2012) 0.84

Impact of MS genetic loci on familial aggregation, clinical phenotype, and disease prediction. Neurol Neuroimmunol Neuroinflamm (2015) 0.84

Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. Mult Scler (2011) 0.84

Interaction between HLA-DRB1-DQB1 haplotypes in Sardinian multiple sclerosis population. PLoS One (2013) 0.82

Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis. Genes Immun (2008) 0.82

Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis. J Neuroimmunol (2011) 0.82

Feasibility study for remote assessment of cognitive function in multiple sclerosis. J Neurol Neuromedicine (2016) 0.82

Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk. Int J Epidemiol (2014) 0.81

Structural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation study. PLoS One (2013) 0.81

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). J Neurol (2009) 0.80

DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands. PLoS One (2012) 0.80

Multiple sclerosis pharmacogenetics: personalized approach towards tailored therapeutics. EPMA J (2010) 0.79

The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania. BMC Neurol (2013) 0.78

SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun (2011) 0.77

Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol (2017) 0.77

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol (2016) 0.77

Multiple sclerosis and the blood-central nervous system barrier. Cardiovasc Psychiatry Neurol (2013) 0.76

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis. Genes Immun (2016) 0.76

A meta-analysis of interaction between Epstein-Barr virus and HLA-DRB1*1501 on risk of multiple sclerosis. Sci Rep (2015) 0.76

Occasional presence of herpes viruses in synovial fluid and blood from patients with rheumatoid arthritis and axial spondyloarthritis. Clin Rheumatol (2015) 0.75

Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the future. Ther Adv Neurol Disord (2009) 0.75

The genetic aspects of multiple sclerosis. Ann Indian Acad Neurol (2009) 0.75

Polyreactive monoclonal autoantibodies in multiple sclerosis: functional selection from phage display library and characterization by deep sequencing analysis. Acta Naturae (2013) 0.75

HLA class I & II alleles in multiple sclerosis patients from Puerto Rico. Bol Asoc Med P R (2013) 0.75

Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Expert Rev Neurother (2014) 0.75

The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis. Medicine (Baltimore) (2016) 0.75

Asparaginase allergies: it's all in the genes. Blood (2014) 0.75

Genomic NGFB variation and multiple sclerosis in a case control study. BMC Med Genet (2008) 0.75

DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-Like Disease: Potential Function of DQB1*06:02 as a Disease-Predisposing Allele. Front Oncol (2014) 0.75

Old game, new players: Linking classical theories to new trends in transplant immunology. World J Transplant (2017) 0.75

Role of tumour necrosis factor (TNF)-α and TNFRSF1A R92Q mutation in the pathogenesis of TNF receptor-associated periodic syndrome and multiple sclerosis. Clin Exp Immunol (2011) 0.75

Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail. JAMA Neurol (2016) 0.75

Obesity and Multiple Sclerosis Susceptibility: A Review. J Neurol Neuromedicine (2016) 0.75

Primary Progressive Multiple Sclerosis: Putting Together the Puzzle. Front Neurol (2017) 0.75

Burden of genetic risk variants in multiple sclerosis families in the Netherlands. Mult Scler J Exp Transl Clin (2016) 0.75

Articles by these authors

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol (2011) 25.66

Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95

Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05

Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med (2010) 13.82

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27

Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09

Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8.33

Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature (2009) 8.12

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet (2004) 7.45

Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39

Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med (2006) 7.18

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16

Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science (2005) 7.03

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44

Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet (2008) 6.42

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol (2009) 5.97

Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood (2005) 5.82

Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39

A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34

European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27

Human mesenchymal stem cells modulate B-cell functions. Blood (2005) 5.12

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85

The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79

No gene is an island: the flip-flop phenomenon. Am J Hum Genet (2007) 4.69

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet (2004) 4.46

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30

Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25

The beautiful and ethereal neurological exam: an appeal for research. Ann Neurol (2011) 4.10

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet (2011) 3.76