Risk alleles for multiple sclerosis identified by a genomewide study.

A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07

Rheumatoid arthritis association at 6q23. Nat Genet (2007) 6.71

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44

Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Am J Hum Genet (2009) 5.65

Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol (2008) 5.08

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet (2009) 4.97

Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79

Autoimmune T cell responses in the central nervous system. Nat Rev Immunol (2009) 4.73

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59

Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet (2009) 3.54

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52

Deconstructing the peptide-MHC specificity of T cell recognition. Cell (2014) 3.24

Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94

Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med (2012) 2.90

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med (2007) 2.88

CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun (2008) 2.76

Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. Am J Hum Genet (2010) 2.64

Long non-coding RNAs in nervous system function and disease. Brain Res (2010) 2.53

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47

Retracted Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med (2010) 2.43

Multiple sclerosis. J Clin Invest (2012) 2.41

Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41

The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A (2009) 2.38

Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study. Lancet Neurol (2014) 2.37

What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet (2008) 2.35

Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet (2007) 2.32

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet (2011) 2.32

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30

Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet (2009) 2.23

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A (2010) 2.19

The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun (2008) 2.17

Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev Immunol (2009) 2.16

A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Ann Hum Genet (2009) 2.15

Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol (2012) 2.15

Risk for multiple sclerosis in relatives and spouses of patients diagnosed with autoimmune and related conditions. Neurogenetics (2008) 2.11

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03

Incidence of acquired CNS demyelinating syndromes in a multiethnic cohort of children. Neurology (2011) 1.99

The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol (2012) 1.97

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet (2009) 1.97

An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings. BMC Genet (2010) 1.96

Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet (2009) 1.93

Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology (2009) 1.93

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol Lett (2007) 1.91

Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis. PLoS Genet (2009) 1.91

Old suspects found guilty--the first genome profile of multiple sclerosis. N Engl J Med (2007) 1.90

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet (2010) 1.89

The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. Eur J Epidemiol (2007) 1.89

Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol (2014) 1.88

Refining genetic associations in multiple sclerosis. Lancet Neurol (2008) 1.85

IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun (2010) 1.83

Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet (2008) 1.81

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Hum Mol Genet (2009) 1.80

Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med (2010) 1.78

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game. J Immunol (2011) 1.76

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS. Mult Scler (2012) 1.75

A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J Neurol (2008) 1.74

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet (2014) 1.74

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology (2009) 1.73

IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis. Sci Transl Med (2011) 1.73

Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS One (2008) 1.72

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A (2009) 1.69

The complex genetics of multiple sclerosis: pitfalls and prospects. Brain (2008) 1.68

Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci (2015) 1.63

Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci U S A (2012) 1.60

Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet (2008) 1.59

Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis. J Neurol Sci (2010) 1.59

An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol (2010) 1.57

Interferon-β inhibits toll-like receptor 9 processing in multiple sclerosis. Ann Neurol (2010) 1.56

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 1.55

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol (2009) 1.55

The inheritance of resistance alleles in multiple sclerosis. PLoS Genet (2007) 1.54

Human regulatory T cells and autoimmunity. Eur J Immunol (2008) 1.54

Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol (2008) 1.52

Unraveling the genetics of autoimmunity. Cell (2010) 1.51

MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood. PLoS One (2010) 1.49

Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes (2010) 1.48

Assessment of the genetic basis of rosacea by genome-wide association study. J Invest Dermatol (2015) 1.48

Multiple sclerosis-a quiet revolution. Nat Rev Neurol (2015) 1.47

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat Rev Neurol (2014) 1.46

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J Clin Invest (2008) 1.44

Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet (2013) 1.42

Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proc Natl Acad Sci U S A (2007) 1.42

Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci (2013) 1.39

Modeling genetic inheritance of copy number variations. Nucleic Acids Res (2008) 1.39

A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PLoS One (2010) 1.38

Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med (2012) 1.38

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain (2008) 1.37

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

The structure of haplotype blocks in the human genome. Science (2002) 50.88

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Integrative genomics viewer. Nat Biotechnol (2011) 42.83

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96

Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins (2003) 32.38

Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60

Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02

Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83

Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature (2003) 29.16

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21

Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol (2009) 27.17

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (2006) 25.99

Efficiency and power in genetic association studies. Nat Genet (2005) 25.56

Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04

High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Proc Natl Acad Sci U S A (2010) 22.97

ARACHNE: a whole-genome shotgun assembler. Genome Res (2002) 22.72

Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00

A molecular signature of metastasis in primary solid tumors. Nat Genet (2002) 21.36

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

ALLPATHS: de novo assembly of whole-genome shotgun microreads. Genome Res (2008) 20.61

International network of cancer genome projects. Nature (2010) 20.35

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08

Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A (2007) 18.83

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81

Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs. Nat Biotechnol (2010) 18.44

The mammalian epigenome. Cell (2007) 18.13

Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51

Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28

Gene expression correlates of clinical prostate cancer behavior. Cancer Cell (2002) 16.27

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol (2013) 16.13

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89