Published in Gastroenterology on September 01, 2006
Adipokines and insulin resistance. Mol Med (2008) 2.97
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab (2008) 2.57
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36
Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm (2010) 1.80
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem Biol Interact (2011) 1.44
Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment. World J Gastroenterol (2008) 1.43
Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples. BMC Mol Biol (2010) 1.42
Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol (2009) 1.41
The metabolically benign and malignant fatty liver. Diabetes (2011) 1.39
Liver diseases and metabolic syndrome. J Gastroenterol (2008) 1.33
Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair (2008) 1.30
Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes. PLoS One (2010) 1.25
Obesity, diabetes mellitus, and liver fibrosis. Am J Physiol Gastrointest Liver Physiol (2011) 1.24
Fat distribution, aerobic fitness, blood lipids, and insulin sensitivity in African-American and European-American women. Obesity (Silver Spring) (2009) 1.17
Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring) (2009) 1.08
Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass. PLoS One (2012) 1.06
Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease. Semin Liver Dis (2013) 1.05
Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol (2010) 1.03
Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. J Nutr Biochem (2010) 1.03
Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. Alcohol Clin Exp Res (2011) 0.98
Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses. J Biol Chem (2012) 0.97
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? Semin Immunopathol (2009) 0.96
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord (2015) 0.94
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes (2012) 0.94
Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity. PLoS One (2012) 0.93
Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice. PLoS One (2012) 0.93
The multi-hit process and the antagonistic roles of tumor necrosis factor-alpha and adiponectin in non alcoholic fatty liver disease. Hippokratia (2009) 0.92
Reversal of liver fibrosis. Saudi J Gastroenterol (2009) 0.90
Adipokines and insulin action: A sensitive issue. Adipocyte (2014) 0.88
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH). Semin Immunopathol (2013) 0.87
Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance. J Clin Biochem Nutr (2015) 0.87
Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance. J Biol Chem (2011) 0.86
Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents. Pediatr Obes (2012) 0.84
Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells. Clin Exp Immunol (2012) 0.84
Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease. Dig Dis Sci (2011) 0.83
Physical Activity is Related to Fatty Liver Marker in Obese Youth, Independently of Central Obesity or Cardiorespiratory Fitness. J Sports Sci Med (2015) 0.83
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82
Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance? PLoS One (2015) 0.82
Steatocholecystitis and fatty gallbladder disease. Dig Dis Sci (2008) 0.81
Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction. Evid Based Complement Alternat Med (2014) 0.80
Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population. Arch Med Sci (2011) 0.79
Non-alcoholic fatty liver disease and psoriasis: So far, so near. World J Hepatol (2015) 0.79
Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children. Eur J Med Res (2009) 0.79
Natural killer T cells and non-alcoholic fatty liver disease: fat chews on the immune system. World J Gastroenterol (2008) 0.79
Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat. Environ Health Prev Med (2012) 0.79
Molecular Pathogenesis of NASH. Int J Mol Sci (2016) 0.78
Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life. Biomed Res Int (2015) 0.78
Chronic prehepatic portal hypertension in the rat: is it a type of metabolic inflammatory syndrome? Lipids Health Dis (2008) 0.78
Combination with Red ginseng and Polygoni Multiflori ameliorates highfructose diet induced metabolic syndrome. BMC Complement Altern Med (2016) 0.78
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. Cancer Prev Res (Phila) (2012) 0.78
The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis. PLoS One (2017) 0.77
Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models. Nutrients (2016) 0.77
Chronic stress induces steatohepatitis while decreases visceral fat mass in mice. BMC Gastroenterol (2014) 0.76
Non-Alcoholic Fatty Liver Disease: Cause or Effect of Metabolic Syndrome. Visc Med (2016) 0.75
Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity. PLoS One (2015) 0.75
Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis. World J Hepatol (2015) 0.75
Increased Expression Profile and Functionality of TLR6 in Peripheral Blood Mononuclear Cells and Hepatocytes of Morbidly Obese Patients with Non-Alcoholic Fatty Liver Disease. Int J Mol Sci (2016) 0.75
Effect of pioglitazone, quercetin and hydroxy citric acid on extracellular matrix components in experimentally induced non-alcoholic steatohepatitis. Iran J Basic Med Sci (2015) 0.75
Computed Tomography Measurement of Hepatic Steatosis: Prevalence of Hepatic Steatosis in a Canadian Population. Can J Gastroenterol Hepatol (2016) 0.75
Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats. Evid Based Complement Alternat Med (2015) 0.75
UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss. BMC Complement Altern Med (2017) 0.75
Linking atrial fibrillation with non-alcoholic fatty liver disease: potential common therapeutic targets. Oncotarget (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Inflammation, stress, and diabetes. J Clin Invest (2005) 17.11
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 9.83
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature (2007) 4.59
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res (2007) 3.96
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab (2005) 3.51
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A (2006) 3.02
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest (2008) 2.55
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation (2003) 2.52
Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med (2010) 2.48
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell (2007) 2.35
Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res (2010) 2.20
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab (2012) 2.04
Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. J Nutr (2004) 2.00
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol (2002) 1.94
Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Biol (2005) 1.92
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One (2008) 1.90
Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes (2003) 1.88
The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol (2011) 1.87
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology (2002) 1.80
Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. Clin Chem (2003) 1.70
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature (2013) 1.69
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation (2004) 1.60
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A (2011) 1.59
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes (2006) 1.56
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. Am J Clin Nutr (2010) 1.55
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med (2013) 1.55
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest (2006) 1.54
The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol (2005) 1.53
Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes (2013) 1.50
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res (2003) 1.34
Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol (2006) 1.31
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26
Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol (2003) 1.25
Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol (2007) 1.25
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab (2013) 1.19
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes (2002) 1.19
Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. PLoS One (2011) 1.13
Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology (2004) 1.09
The role of JNK proteins in metabolism. Sci Transl Med (2010) 1.09
Linking the inflammasome to obesity-related disease. Nat Med (2011) 1.05
Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metab (2003) 1.02
Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet (2012) 1.01
FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes (2013) 0.98
Stressing the brain, fattening the body. Cell (2008) 0.96
Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol (2013) 0.95
The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep (2013) 0.95
Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. Curr Atheroscler Rep (2007) 0.93
Turning off the inflammatory, but not the metabolic, flames. Nat Med (2013) 0.93
Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes. Arterioscler Thromb Vasc Biol (2011) 0.93
Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol (2002) 0.92
Metabolism: Host and microbes in a pickle. Nature (2010) 0.89
Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol (2013) 0.87
Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab (2012) 0.86
Developmental biology: cell fate in the mammary gland. Nature (2007) 0.85
GATA transcription factors and fat cell formation. Drug News Perspect (2003) 0.85
Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol (2006) 0.85
Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization. Cell Metab (2013) 0.84
Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem (2012) 0.83
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One (2013) 0.83
Impact of ER protein homeostasis on metabolism. Diabetes (2013) 0.82
The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep (2005) 0.82
Promoting atherosclerosis in type 1 diabetes through the selective activation of arachidonic acid and PGE(2) production. Circ Res (2012) 0.76
Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med (2017) 0.75