Published in J Nutr Biochem on September 11, 2006
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med (2009) 2.33
Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter. Vitam Horm (2008) 1.05
Dietary folate deficiency blocks prostate cancer progression in the TRAMP model. Cancer Prev Res (Phila) (2011) 0.89
The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice. BMC Cancer (2009) 0.80
The essential role of methylthioadenosine phosphorylase in prostate cancer. Oncotarget (2016) 0.79
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet (2002) 3.11
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Am J Obstet Gynecol (2008) 2.82
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet (2009) 2.58
Neural tube defects and folate: case far from closed. Nat Rev Neurosci (2006) 2.30
A new partner for the international knockout mouse consortium. Cell (2007) 2.23
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem (2002) 2.20
Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2. J Med Genet (2006) 2.10
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res (2008) 2.08
Characteristics of users of online personalized genomic risk assessments: implications for physician-patient interactions. Genet Med (2009) 2.07
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circ Res (2006) 1.99
Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98
Maternal periconceptional vitamins: interactions with selected factors and congenital anomalies? Epidemiology (2002) 1.93
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Nat Cell Biol (2009) 1.90
The continuing challenge of understanding, preventing, and treating neural tube defects. Science (2013) 1.86
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
Variation in IRF6 contributes to nonsyndromic cleft lip and palate. Am J Med Genet A (2005) 1.82
Putting science over supposition in the arena of personalized genomics. Nat Genet (2008) 1.80
Participation in genetic testing research varies by social group. Public Health Genomics (2010) 1.79
Functional characterization of BRCA1 sequence variants using a yeast small colony phenotype assay. Cancer Biol Ther (2004) 1.75
Patients' understanding of and responses to multiplex genetic susceptibility test results. Genet Med (2012) 1.75
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet (2009) 1.74
Point: genetic risk feedback for common disease time to test the waters. Cancer Epidemiol Biomarkers Prev (2007) 1.64
Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. Epidemiology (2004) 1.63
A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood (2011) 1.62
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet (2006) 1.52
Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects. J Pediatr (2008) 1.52
Locus-specific databases and recommendations to strengthen their contribution to the classification of variants in cancer susceptibility genes. Hum Mutat (2008) 1.44
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics (2009) 1.44
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab (2003) 1.44
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci U S A (2011) 1.38
Novel mutations in VANGL1 in neural tube defects. Hum Mutat (2009) 1.37
Consumers' use of web-based information and their decisions about multiplex genetic susceptibility testing. J Med Internet Res (2010) 1.35
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood (2002) 1.34
Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull (2008) 1.33
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res (2003) 1.31
Association between health-service use and multiplex genetic testing. Genet Med (2012) 1.29
Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab (2003) 1.25
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. BMJ (2004) 1.24
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab (2007) 1.24
Integration of DNA sample collection into a multi-site birth defects case-control study. Teratology (2002) 1.22
Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. Am J Med Genet A (2005) 1.18
Choline and risk of neural tube defects in a folate-fortified population. Epidemiology (2009) 1.18
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate. Birth Defects Res A Clin Mol Teratol (2008) 1.18
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr (2005) 1.17
Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. Am J Med Genet (2002) 1.17
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr (2005) 1.17
Folic acid in early pregnancy: a public health success story. FASEB J (2010) 1.16
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J Biol Chem (2012) 1.16
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A (2012) 1.16
Maternal occupational exposure to polycyclic aromatic hydrocarbons: effects on gastroschisis among offspring in the National Birth Defects Prevention Study. Environ Health Perspect (2012) 1.16
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Hum Mutat (2009) 1.16
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Hum Mutat (2009) 1.15
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest (2010) 1.14
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem (2008) 1.14
Screening student athletes for sickle cell trait--a social and clinical experiment. N Engl J Med (2010) 1.14
Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS One (2011) 1.14
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (2006) 1.13
Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts. Birth Defects Res A Clin Mol Teratol (2004) 1.13
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice. Am J Clin Nutr (2005) 1.11
Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation. Dev Dyn (2004) 1.10
In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model (2006) 1.10
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Reduced folate carrier polymorphism (80A-->G) and neural tube defects. Eur J Hum Genet (2003) 1.08
Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. Birth Defects Res A Clin Mol Teratol (2010) 1.08
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med (2012) 1.08
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. BMC Med Genet (2012) 1.08
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J (2009) 1.07
Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model. Carcinogenesis (2005) 1.07
Folate pathway and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol (2010) 1.06
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients. Toxicol Appl Pharmacol (2005) 1.06
Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet (2002) 1.06
Investigations into the etiology of neural tube defects. Birth Defects Res C Embryo Today (2004) 1.05
The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. Am J Med Genet A (2007) 1.05
Teratogenic effects of antiepileptic drugs. Expert Rev Neurother (2010) 1.05
Whole genome microarray analysis, from neonatal blood cards. BMC Genet (2009) 1.05
Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? Am J Med Genet A (2005) 1.04
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology (2010) 1.04
Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population. Int J Circumpolar Health (2002) 1.04
Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts. Am J Epidemiol (2005) 1.04
Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects. J Hum Genet (2003) 1.04
Epidemiologic characteristics of anophthalmia and bilateral microphthalmia among 2.5 million births in California, 1989-1997. Am J Med Genet A (2005) 1.04
Autoantibodies to folate receptor during pregnancy and neural tube defect risk. J Reprod Immunol (2008) 1.03
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol (2009) 1.03
Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive history. Epidemiology (2002) 1.02
Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Am J Hum Genet (2002) 1.02
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr (2010) 1.01
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. J Invest Dermatol (2010) 1.01
Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation (2005) 1.01