Published in J Biol Chem on April 20, 2006
SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS One (2009) 1.51
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. J Biol Chem (2009) 1.31
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J Biol Chem (2012) 1.16
Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. J Biol Chem (2010) 1.07
Serine and one-carbon metabolism in cancer. Nat Rev Cancer (2016) 1.06
FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism. Chem Biol Interact (2008) 1.04
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (2010) 1.03
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. J Nutrigenet Nutrigenomics (2012) 1.01
One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. Hum Genet (2007) 0.98
A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis. PLoS One (2011) 0.96
Proteomic analysis of fructose-induced fatty liver in hamsters. Metabolism (2008) 0.89
Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress. Genes Cancer (2011) 0.87
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. J Biol Chem (2013) 0.85
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med (2012) 0.84
Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (2009) 0.83
Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. Chem Biol Interact (2011) 0.83
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes. Chem Biol Interact (2011) 0.83
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles. BMC Genomics (2013) 0.82
10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status. Mol Cancer Res (2009) 0.81
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. Mol Med (2011) 0.80
Comparison of protein expression profiles of the hepatopancreas in Fenneropenaeus chinensis challenged with heat-inactivated Vibrio anguillarum and white spot syndrome virus. Mar Biotechnol (NY) (2013) 0.79
Methotrexate-induced decrease in embryonic 5-methyl-tetrahydrofolate is irreversible with leucovorin supplementation. Zebrafish (2013) 0.78
Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition. Acta Crystallogr D Biol Crystallogr (2015) 0.75
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells. J Nutr (2017) 0.75
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr (2007) 4.37
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 4.34
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med (2005) 3.17
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst (2003) 2.92
A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev (2007) 2.91
Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation (2011) 2.62
C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes (2008) 2.50
Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation (2010) 2.32
Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med (2005) 2.29
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem (2002) 2.20
Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet (2008) 2.07
A multi-marker approach to predict incident CKD and microalbuminuria. J Am Soc Nephrol (2010) 1.95
Folic acid intake from fortification in United States exceeds predictions. J Nutr (2002) 1.94
Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr (2006) 1.89
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
Folate-mediated one-carbon metabolism. Vitam Horm (2008) 1.81
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem (2008) 1.73
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr (2004) 1.70
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone (2005) 1.69
High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke (2008) 1.67
Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol (2002) 1.66
Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation (2007) 1.65
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. J Biol Chem (2007) 1.65
Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med (2002) 1.63
Relationship between homocysteine and mortality in chronic kidney disease. Circulation (2006) 1.58
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr (2011) 1.53
SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS One (2009) 1.51
The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry (2006) 1.50
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab (2003) 1.44
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Res C Embryo Today (2007) 1.42
Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase. Clin Chem Lab Med (2007) 1.38
B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A (2008) 1.37
Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr (2008) 1.37
Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J (2004) 1.37
Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst (2005) 1.36
Circulating folic acid in plasma: relation to folic acid fortification. Am J Clin Nutr (2008) 1.35
The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A (2003) 1.35
Elevated plasma osteopontin associated with gastric cancer development, invasion and survival. Gut (2006) 1.35
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood (2002) 1.34
Multiple biomarkers and the risk of incident hypertension. Hypertension (2007) 1.34
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age (Dordr) (2006) 1.33
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr (2010) 1.32
Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A (2011) 1.30
Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis (2004) 1.30
Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA (2003) 1.30
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr (2009) 1.28
Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma. J Biol Chem (2005) 1.28
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr (2008) 1.26
Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation (2008) 1.26
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology (2007) 1.23
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr (2008) 1.22
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am J Clin Nutr (2011) 1.19
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr (2005) 1.17
Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr (2002) 1.17
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr (2005) 1.17
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. Cancer Res (2011) 1.16
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J Biol Chem (2012) 1.16
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr (2008) 1.15
Multimarker approach for the prediction of heart failure incidence in the community. Circulation (2010) 1.15
Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci U S A (2004) 1.15
Trafficking of intracellular folates. Adv Nutr (2011) 1.15
Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol (2008) 1.14
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem (2008) 1.14
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14
Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS One (2011) 1.14
One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev (2008) 1.14
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology (2002) 1.13
Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res (2004) 1.13
Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution. Clin Cancer Res (2007) 1.12
Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol (2005) 1.10
In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model (2006) 1.10
A ferritin-responsive internal ribosome entry site regulates folate metabolism. J Biol Chem (2007) 1.09
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr (2009) 1.09
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. BMC Med Genet (2012) 1.08
Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr (2004) 1.07