Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMC 1599930)

Published in Proc Natl Acad Sci U S A on September 11, 2006

Authors

Elaine E Hamm1, Daniel E Voth, Jimmy D Ballard

Author Affiliations

1: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Articles citing this

Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol (2009) 7.89

Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. J Infect Dis (2011) 1.98

Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology (2014) 1.77

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature (2016) 1.47

The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives. Gut Microbes (2010) 1.37

An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. J Microbiol Methods (2009) 1.34

Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile. PLoS Pathog (2010) 1.26

Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease. J Infect Dis (2012) 1.25

Clostridium difficile toxins: mediators of inflammation. J Innate Immun (2012) 1.21

Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun (2009) 1.21

Clostridium difficile infection. Am J Med Sci (2010) 1.17

Models for the study of Clostridium difficile infection. Gut Microbes (2012) 1.16

Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB. PLoS Pathog (2013) 1.08

The enterotoxicity of Clostridium difficile toxins. Toxins (Basel) (2010) 1.07

Clostridium difficile in the ICU: the struggle continues. Chest (2011) 1.01

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections. MBio (2015) 0.99

Variations in virulence and molecular biology among emerging strains of Clostridium difficile. Microbiol Mol Biol Rev (2013) 0.99

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res (2014) 0.97

TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing. Mol Microbiol (2012) 0.93

The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge. Zoonoses Public Health (2010) 0.93

Clostridium difficile infection: molecular pathogenesis and novel therapeutics. Expert Rev Anti Infect Ther (2014) 0.92

Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun (2014) 0.91

Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice. Vaccine (2011) 0.91

Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen. Gut Microbes (2014) 0.86

Vaccination against Clostridium difficile using toxin fragments: Observations and analysis in animal models. Gut Microbes (2014) 0.85

Identification of toxemia in patients with Clostridium difficile infection. PLoS One (2015) 0.84

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo. Infect Immun (2014) 0.80

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects. Toxins (Basel) (2016) 0.77

'Get in Early'; Biofilm and Wax Moth (Galleria mellonella) Models Reveal New Insights into the Therapeutic Potential of Clostridium difficile Bacteriophages. Front Microbiol (2016) 0.77

A Perspective on the Toxicity of Low Concentrations of Petroleum-Derived Polycyclic Aromatic Hydrocarbons to Early Life Stages of Herring and Salmon. Hum Ecol Risk Assess (2012) 0.77

The roles of toxin A and toxin B in Clostridium difficile infection: insights from the gnotobiotic piglet model. Gut Microbes (2013) 0.75

Articles cited by this

Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature (1995) 6.08

Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev (2005) 5.69

Effects of Clostridium difficile toxins given intragastrically to animals. Infect Immun (1985) 5.44

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation (1998) 3.72

Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (1996) 3.63

Headwaters of the zebrafish -- emergence of a new model vertebrate. Nat Rev Genet (2002) 3.56

Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity (2002) 3.48

Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol Microbiol (1995) 2.96

Fatal pseudomembranous colitis associated with a variant clostridium difficile strain not detected by toxin A immunoassay. Ann Intern Med (2001) 2.72

Drosophila as a model host for Pseudomonas aeruginosa infection. J Bacteriol (2001) 2.36

Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster. Cell Microbiol (2003) 2.34

Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides. J Biol Chem (1993) 2.23

Clostridium difficile toxin B acts on the GTP-binding protein Rho. J Biol Chem (1994) 2.09

Streptococcus-zebrafish model of bacterial pathogenesis. Infect Immun (2002) 2.01

Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections. Cell Microbiol (2003) 1.98

The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. Development (2002) 1.97

Clostridium difficile colitis associated with chronic renal failure. Nephrol Dial Transplant (1998) 1.94

Differential effects of Clostridium difficile toxins on tissue-cultured cells. J Clin Microbiol (1982) 1.87

A star with stripes: zebrafish as an infection model. Trends Microbiol (2004) 1.76

pH-induced conformational changes in Clostridium difficile toxin B. Infect Immun (2000) 1.75

Drosophila melanogaster is a genetically tractable model host for Mycobacterium marinum. Infect Immun (2003) 1.73

Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model. Cell Microbiol (2003) 1.70

VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev (2005) 1.53

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol (1999) 1.48

Ultrastructural effects of Clostridium difficile toxin B on smooth muscle cells and fibroblasts. Exp Cell Res (1983) 1.46

Tackling both sides of the host-pathogen equation with Caenorhabditis elegans. Microbes Infect (2002) 1.44

Sensitivity in culture of epithelial cells from rhesus monkey kidney and human colon carcinoma to toxins A and B from Clostridium difficile. Toxicon (1992) 1.31

Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome. Intensive Care Med (2003) 1.28

Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity. Cell Microbiol (2005) 1.25

Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells. Cell Microbiol (2002) 1.25

Internalization of Clostridium difficile cytotoxin into cultured human lung fibroblasts. Biochim Biophys Acta (1983) 1.23

Mice, microbes and models of infection. Nat Rev Genet (2003) 1.20

Bacterial toxins: friends or foes? Emerg Infect Dis (1999) 1.18

Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS Microbiol Lett (2003) 1.17

Genetic models in pathogenesis. Annu Rev Genet (2004) 1.14

Clostridium difficile and acute respiratory distress syndrome. Heart Lung (2004) 1.11

A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C. difficile toxin B and C. sordellii lethal toxin. Toxicon (1991) 1.10

Bacterial toxins inhibiting or activating small GTP-binding proteins. Ann N Y Acad Sci (1999) 1.08

Zebrafish as a model host for streptococcal pathogenesis. Acta Trop (2004) 1.08

Cytosolic delivery and characterization of the TcdB glucosylating domain by using a heterologous protein fusion. Infect Immun (2001) 1.07

New directions in strategies using cell therapy for heart disease. J Mol Med (Berl) (2003) 1.04

Ultrastructural changes of cultured human amnion cells by Clostridiu difficile toxin. Infect Immun (1979) 0.99

Liver abscess caused by Clostridium difficile. Scand J Infect Dis (2001) 0.95

Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cell Microbiol (2003) 0.92

Is cardiorespiratory failure induced by bacterial toxins the cause of sudden infant death syndrome? Studies with an animal model (the rabbit). Toxicon (1995) 0.91

In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia. Eur J Pharmacol (2000) 0.91

A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase. J Neurochem (2000) 0.88

Clostridium difficile toxins A and B inhibit human immune response in vitro. Infect Immun (1988) 0.85

Advances in the molecular mechanisms of heart failure. Curr Opin Cardiol (2000) 0.83

Bacterial toxins and the immune system: show me the in vivo targets. J Exp Med (2005) 0.83

[Selenium deficiency favors the appearance of heart failure after multiple injury]. Ann Fr Anesth Reanim (1997) 0.78

Pseudomembranous colitis with fatal outcome in a 43-year-old man. Leg Med (Tokyo) (2002) 0.77

In vitro effects of Clostridium difficile toxins on hepatocytes. J Surg Res (1998) 0.77

Articles by these authors

Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev (2005) 5.69

Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella. Infect Immun (2008) 2.38

Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages. MBio (2011) 1.76

Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59

Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile. PLoS Pathog (2010) 1.26

Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells. Cell Microbiol (2002) 1.25

Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity. Cell Microbiol (2005) 1.25

Clostridium difficile infection. Am J Med Sci (2010) 1.17

Proteome and antigen profiling of Coxiella burnetii developmental forms. Infect Immun (2006) 1.14

A method adapting microarray technology for signature-tagged mutagenesis of Desulfovibrio desulfuricans G20 and Shewanella oneidensis MR-1 in anaerobic sediment survival experiments. Appl Environ Microbiol (2005) 1.12

Effects of endogenous D-alanine synthesis and autoinhibition of Bacillus anthracis germination on in vitro and in vivo infections. Infect Immun (2007) 1.11

Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08

Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB. PLoS Pathog (2013) 1.08

Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages. Cell Microbiol (2013) 1.06

Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. PLoS Pathog (2009) 1.02

Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies. Infect Immun (2008) 1.01

Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge. J Infect Dis (2010) 1.01

Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages. Proc Natl Acad Sci U S A (2003) 1.00

CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. Infect Immun (2010) 1.00

Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cell Microbiol (2006) 0.99

The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes. Infect Immun (2009) 0.99

Anthrax vaccination induced anti-lethal factor IgG: fine specificity and neutralizing capacity. Vaccine (2011) 0.99

Variations in virulence and molecular biology among emerging strains of Clostridium difficile. Microbiol Mol Biol Rev (2013) 0.99

Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun (2010) 0.99

Variations in lethal toxin and cholesterol-dependent cytolysin production correspond to differences in cytotoxicity among strains of Clostridium sordellii. FEMS Microbiol Lett (2006) 0.98

Refining the plasmid-encoded type IV secretion system substrate repertoire of Coxiella burnetii. J Bacteriol (2013) 0.97

Clostridium sordellii toxic shock syndrome. Lancet Infect Dis (2009) 0.96

Desulfovibrio sp. genes involved in the respiration of sulfate during metabolism of hydrogen and lactate. Appl Environ Microbiol (2002) 0.96

Medical microbiology: A toxin contest. Nature (2010) 0.95

Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomes. Infect Immun (2014) 0.95

Regulatory interactions of a virulence-associated serine/threonine phosphatase-kinase pair in Bacillus anthracis. J Bacteriol (2009) 0.95

TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing. Mol Microbiol (2012) 0.93

Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation. Front Microbiol (2010) 0.93

Functional comparison of the two Bacillus anthracis glutamate racemases. J Bacteriol (2007) 0.92

Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cell Microbiol (2003) 0.92

Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFNγ. PLoS One (2011) 0.91

Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages. Infect Immun (2011) 0.90

Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J Immunol (2009) 0.90

Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE). J Biol Chem (2013) 0.89

Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication. PLoS Pathog (2013) 0.88

Identification of Anaplasma marginale type IV secretion system effector proteins. PLoS One (2011) 0.88

Genes that enhance the ecological fitness of Shewanella oneidensis MR-1 in sediments reveal the value of antibiotic resistance. Appl Environ Microbiol (2006) 0.87

High-throughput, single-cell analysis of macrophage interactions with fluorescently labeled Bacillus anthracis spores. Appl Environ Microbiol (2008) 0.87

Mutational analysis of the enzymatic domain of Clostridium difficile toxin B reveals novel inhibitors of the wild-type toxin. Infect Immun (2003) 0.86

Bacillus anthracis edema toxin activates nuclear glycogen synthase kinase 3beta. Infect Immun (2008) 0.85

Identification of genes that confer sediment fitness to Desulfovibrio desulfuricans G20. Appl Environ Microbiol (2007) 0.85

Coxiella burnetii alters cyclic AMP-dependent protein kinase signaling during growth in macrophages. Infect Immun (2012) 0.83

The mechanism of Bacillus anthracis intracellular germination requires multiple and highly diverse genetic loci. Infect Immun (2008) 0.83

Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival. Cell Microbiol (2013) 0.83

Cheating death: a coxiella effector prevents apoptosis. Front Microbiol (2011) 0.83

Clostridium sordellii lethal toxin is maintained in a multimeric protein complex. Infect Immun (2004) 0.82

Evidence for chimeric sequences formed during random arbitrarily primed PCR. J Microbiol Methods (2003) 0.80

Adenomatous polyposis coli protein associates with C/EBP beta and increases Bacillus anthracis edema toxin-stimulated gene expression in macrophages. J Biol Chem (2011) 0.79

Elucidating the in vivo targets of bacterial toxins. Future Microbiol (2007) 0.79

Toxin inhibition of antimicrobial factors induced by Bacillus anthracis peptidoglycan in human blood. Infect Immun (2013) 0.78

Differential expression of Desulfovibrio vulgaris genes in response to Cu(II) and Hg(II) toxicity. Appl Environ Microbiol (2004) 0.78

Coxiella subversion of intracellular host signaling. Adv Exp Med Biol (2012) 0.77

Autoregulatory characteristics of a Bacillus anthracis serine/threonine kinase. J Bacteriol (2011) 0.77

Critical intermediate steps in Clostridium sordellii lethal toxin-induced apoptosis. Biochem Biophys Res Commun (2007) 0.76

Determination of serum antibodies to Clostridium difficile toxin B in patients with inflammatory bowel disease. Gastroenterol Hepatol (N Y) (2012) 0.75

Serum amyloid A protects murine macrophages from lethal toxin-mediated death. Cell Immunol (2011) 0.75

Differential inflammatory responses triggered by toxic small molecules. Environ Sci Pollut Res Int (2011) 0.75