Published in Cell Cycle on October 01, 2006
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell (2008) 3.42
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A (2011) 1.90
Retracted A cell cycle regulatory network controlling NF-kappaB subunit activity and function. EMBO J (2007) 1.58
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol (2011) 1.53
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer (2011) 1.39
Claspin promotes normal replication fork rates in human cells. Mol Biol Cell (2008) 1.38
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Mol Cell Biol (2011) 1.21
Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability. J Cell Biol (2008) 1.14
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One (2010) 1.12
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection. J Virol (2008) 1.11
Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling. Am J Hum Genet (2007) 1.06
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J (2013) 1.05
Heterozygous mutations in PALB2 cause DNA replication and damage response defects. Nat Commun (2013) 1.02
A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function. J Biol Chem (2008) 1.02
BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression. Nucleic Acids Res (2010) 1.02
Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle (2012) 1.01
Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. Leuk Lymphoma (2008) 1.00
Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol (2011) 1.00
Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. Oncotarget (2012) 0.97
The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell (2013) 0.94
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Mol Cell (2015) 0.93
Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Chromosome Res (2010) 0.93
Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol (2008) 0.91
The fork and the kinase: a DNA replication tale from a CHK1 perspective. Mutat Res Rev Mutat Res (2014) 0.87
Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. PLoS One (2011) 0.84
SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. PLoS One (2013) 0.81
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest (2011) 0.81
Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress. Nucleic Acids Res (2014) 0.81
Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Oncotarget (2016) 0.80
Telomere shortening in cultured human dermal fibroblasts is associated with acute photodamage induced by UVA irradiation. Postepy Dermatol Alergol (2013) 0.78
Downregulation of Col1a1 induces differentiation in mouse spermatogonia. Asian J Androl (2012) 0.77
p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells. Int J Cancer (2014) 0.77
DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts. Photochem Photobiol (2014) 0.76
Human CDK18 promotes replication stress signaling and genome stability. Nucleic Acids Res (2016) 0.76
Hpz1 modulates the G1-S transition in fission yeast. PLoS One (2012) 0.75
Role of DNA polymerase κ in the maintenance of genomic stability. Mol Cell Oncol (2014) 0.75
Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry (2016) 0.75
Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase. Oncotarget (2016) 0.75
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res (2003) 3.85
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature (2005) 2.98
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
DNA strand break repair and human genetic disease. Annu Rev Genomics Hum Genet (2007) 2.80
Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat Genet (2010) 2.74
Spatial and temporal cellular responses to single-strand breaks in human cells. Mol Cell Biol (2003) 2.70
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell (2004) 2.46
Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J (2007) 2.44
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature (2009) 2.33
Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Mol Cell Biol (2006) 2.05
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. DNA Repair (Amst) (2004) 1.86
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J (2007) 1.85
PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell (2011) 1.77
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71
Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. DNA Repair (Amst) (2003) 1.70
Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair. Mol Cell Biol (2002) 1.64
TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem (2010) 1.50
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci (2009) 1.43
APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Mol Cell Biol (2008) 1.41
Claspin promotes normal replication fork rates in human cells. Mol Biol Cell (2008) 1.38
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Res (2003) 1.32
TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. DNA Repair (Amst) (2007) 1.28
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Mol Cancer Ther (2009) 1.20
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Res (2012) 1.18
Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol Cell Biol (2008) 1.16
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair (Amst) (2009) 1.16
Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1. EMBO J (2002) 1.14
DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress. Mol Cell Biol (2009) 1.14
XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Res (2004) 1.13
APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J (2012) 1.09
Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. Methods Enzymol (2006) 1.08
XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. J Biol Chem (2007) 1.06
Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. Biochemistry (2004) 1.03
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet (2013) 1.03
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Res (2013) 0.97
Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair. Nucleic Acids Res (2012) 0.93
Short-patch single-strand break repair in ataxia oculomotor apraxia-1. Biochem Soc Trans (2009) 0.88
DNA strand break repair and neurodegeneration. DNA Repair (Amst) (2013) 0.86
Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose. Nat Struct Mol Biol (2012) 0.84
TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis (2006) 0.83
DNA damage responses and neurological disease. Preface. DNA Repair (Amst) (2008) 0.75
3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease". Mech Ageing Dev (2011) 0.75
An Achilles' heel for breast cancer? Nat Struct Mol Biol (2005) 0.75