TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

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Published in J Biol Chem on October 28, 2010

Authors

Zhihong Zeng1, Felipe Cortés-Ledesma, Sherif F El Khamisy, Keith W Caldecott

Author Affiliations

1: Genome Damage and Stability Centre, Science Park Road, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.

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