Published in Mol Cell Oncol on July 15, 2014
Translesion Synthesis DNA Polymerase Kappa Is Indispensable for DNA Repair Synthesis in Cisplatin Exposed Dorsal Root Ganglion Neurons. Mol Neurobiol (2017) 0.75
Evolutionary dynamics and significance of multiple subclonal mutations in cancer. DNA Repair (Amst) (2017) 0.75
Serial analysis of gene expression. Science (1995) 60.15
Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res (1988) 32.89
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Expandable DNA repeats and human disease. Nature (2007) 5.50
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
Trading places: how do DNA polymerases switch during translesion DNA synthesis? Mol Cell (2005) 3.25
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell (2007) 2.46
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair. Nat Cell Biol (2006) 2.45
Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Genes Dev (2000) 2.38
Non-B DNA structure-induced genetic instability and evolution. Cell Mol Life Sci (2009) 2.37
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J (2009) 2.37
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18
Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A (1999) 2.15
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell (2010) 2.09
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem (2000) 2.06
Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc Natl Acad Sci U S A (2002) 1.98
Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol Cell Biol (2006) 1.85
Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell (2010) 1.84
Checkpoint activation regulates mutagenic translesion synthesis. Genes Dev (2003) 1.81
The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst) (2005) 1.81
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. Proc Natl Acad Sci U S A (2002) 1.59
Y-family DNA polymerases in mammalian cells. Cell Mol Life Sci (2009) 1.56
Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle (2006) 1.53
Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis. Cell Cycle (2010) 1.51
Role of human DNA polymerase kappa as an extender in translesion synthesis. Proc Natl Acad Sci U S A (2002) 1.51
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A (2010) 1.48
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem (2009) 1.48
Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics (2006) 1.47
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci U S A (2009) 1.34
A 'DNA replication' signature of progression and negative outcome in colorectal cancer. Oncogene (2009) 1.33
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis. J Cell Biol (2013) 1.30
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene. J Biol Chem (2001) 1.28
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog (2009) 1.24
Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci. J Cell Sci (2004) 1.15
Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. J Mol Biol (2010) 1.12
Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J Biol Chem (2007) 1.11
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer. Cancer Res (2001) 1.09
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. Cancer Res (2005) 1.09
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. EMBO J (2011) 1.08
Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability. Nucleic Acids Res (2011) 1.07
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J (2013) 1.05
Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro Oncol (2010) 1.03
Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa. DNA Repair (Amst) (2003) 1.03
Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells. Proc Natl Acad Sci U S A (2010) 1.02
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients. Oncogenesis (2012) 1.00
Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers. Cancer Lett (2005) 0.99
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint. Cell Cycle (2007) 0.99
Postreplication gaps at UV lesions are signals for checkpoint activation. Proc Natl Acad Sci U S A (2010) 0.98
Localisation of human DNA polymerase kappa to replication foci. J Cell Sci (2002) 0.98
Polk mutant mice have a spontaneous mutator phenotype. DNA Repair (Amst) (2009) 0.97
The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity. J Mol Biol (2013) 0.96
Overexpression of DNA polymerase beta: a genomic instability enhancer process. FASEB J (1999) 0.96
Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage. J Biol Chem (2005) 0.96
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer. Oncogene (2006) 0.95
Replication-independent repair of DNA interstrand crosslinks. Mol Cell (2012) 0.95
Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs? Bioessays (2013) 0.94
A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. PLoS Genet (2012) 0.93
Separate roles of structured and unstructured regions of Y-family DNA polymerases. Adv Protein Chem Struct Biol (2009) 0.93
Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer. Semin Cancer Biol (2010) 0.92
Elevated mutation rates in the germline of Polkappa mutant male mice. DNA Repair (Amst) (2006) 0.91
Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. J Mol Biol (2012) 0.88
PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage. Nucleic Acids Res (2014) 0.87
Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair (Amst) (2013) 0.86
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome. DNA Repair (Amst) (2013) 0.85
Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletions. Nucleic Acids Res (2013) 0.84
Y-family polymerase conformation is a major determinant of fidelity and translesion specificity. Structure (2012) 0.83
Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide. Environ Toxicol Pharmacol (2011) 0.78
Identification of two functional PCNA-binding domains in human DNA polymerase κ. Genes Cells (2014) 0.78