Published in J Appl Physiol (1985) on September 01, 2006
Point: Hypoxic pulmonary vasoconstriction is mediated by increased production of reactive oxygen species. J Appl Physiol (1985) (2006) 4.61
Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species. J Appl Physiol (1985) (2006) 2.48
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J Cell Sci (2003) 2.46
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J (2006) 2.13
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11
Altered pulmonary vascular reactivity in mice with excessive erythrocytosis. Am J Respir Crit Care Med (2003) 1.48
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest (2016) 1.42
Cellular oxygen sensing need in CNS function: physiological and pathological implications. J Exp Biol (2004) 1.36
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J (2003) 1.36
Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2. J Biol Chem (2006) 1.29
Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol (2007) 1.29
The proinflammatory cytokine interleukin 1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells through hypoxia inducible factor 1 activation. Cancer Res (2005) 1.24
Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol (2006) 1.21
A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Proc Natl Acad Sci U S A (2004) 1.17
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood (2002) 1.11
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem (2009) 1.08
NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells. Am J Physiol Cell Physiol (2002) 1.07
Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. J Am Coll Cardiol (2007) 1.07
Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem (2003) 1.06
Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem (2009) 1.04
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases. Cardiovasc Res (2006) 1.03
Hypoxia-induced erythropoietin expression in human neuroblastoma requires a methylation free HIF-1 binding site. J Cell Biochem (2004) 1.00
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells. Free Radic Biol Med (2005) 1.00
Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha. J Biol Chem (2004) 0.99
The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis. Anesthesiology (2013) 0.99
Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation. J Interferon Cytokine Res (2005) 0.98
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J Biol Chem (2004) 0.98
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood (2012) 0.95
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res (2011) 0.95
Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide. J Biol Chem (2008) 0.95
Retracted Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC. Blood (2011) 0.94
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res (2012) 0.94
Retracted Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance. J Immunol (2009) 0.92
Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression. News Physiol Sci (2000) 0.91
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab Invest (2003) 0.90
Neural substrates for behaviorally conditioned immunosuppression in the rat. J Neurosci (2005) 0.89
Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1. Thromb Haemost (2003) 0.89
Oxygen-sensing under the influence of nitric oxide. Cell Signal (2010) 0.89
Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. Endocrinology (2008) 0.88
Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis. Blood (2003) 0.88
Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies. Anesthesiology (2013) 0.87
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood (2012) 0.87
Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells. Biol Chem (2013) 0.86
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis (2009) 0.86
Optical analysis of the HIF-1 complex in living cells by FRET and FRAP. FASEB J (2006) 0.85
Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors. Biochem Biophys Res Commun (2009) 0.85
Thrombopoietin gene expression in the developing human central nervous system. Brain Res Dev Brain Res (2003) 0.85
Myeloid hypoxia-inducible factor-1α is essential for skeletal muscle regeneration in mice. J Immunol (2013) 0.85
Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1. Am J Physiol Regul Integr Comp Physiol (2004) 0.84
Oxygenation and response to irradiation of organotypic multicellular spheroids of human glioma. Anticancer Res (2003) 0.84
The HIF-1 response to simulated ischemia in mouse skeletal muscle cells neither enhances glycolysis nor prevents myotube cell death. Am J Physiol Regul Integr Comp Physiol (2007) 0.84
Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling. J Cell Sci (2012) 0.84
Unusual cytochrome a592 with low PO2 affinity correlates as putative oxygen sensor with rat carotid body chemoreceptor discharge. FASEB J (2002) 0.82
Single- and two-photon spectral imaging of intrinsic fluorescence of transformed human hepatocytes. Microsc Res Tech (2007) 0.82
A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica (2014) 0.82
A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit. J Clin Endocrinol Metab (2011) 0.81
Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat. J Invest Surg (2010) 0.80
Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo. Am J Physiol Cell Physiol (2011) 0.80
Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis. Br J Haematol (2002) 0.80
Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. Br J Haematol (2014) 0.80
Molecular imaging: into in vivo interaction of HIF-1alpha and HIF-2alpha with ARNT. Ann N Y Acad Sci (2009) 0.79
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS One (2011) 0.79
More insights into the CCN3/Connexin43 interaction complex and its role for signaling. J Cell Biochem (2010) 0.79
Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures. Biol Chem (2004) 0.79
Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis. Anesthesiology (2016) 0.79
A cordial affair - erythropoietin and cardioprotection. Cardiovasc Res (2006) 0.78
No evidence for protective erythropoietin alpha signalling in rat hepatocytes. BMC Gastroenterol (2009) 0.77
The impact of N-nitrosomelatonin as nitric oxide donor in cell culture experiments. J Pineal Res (2008) 0.77
Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris. Shock (2011) 0.77
Measurement of ROS Levels and Membrane Potential Dynamics in the Intact Carotid Body Ex Vivo. Adv Exp Med Biol (2015) 0.77
Monitoring of cellular responses to hypoxia. Methods Mol Biol (2010) 0.77
Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signaling. Biol Chem (2010) 0.75
Nanoscopy of the cellular response to hypoxia by means of fluorescence resonance energy transfer (FRET) and new FRET software. PMC Biophys (2010) 0.75
Hypoxia induced gene expression: the specificity switch! Cell Cycle (2015) 0.75
Oxygen and the cell. Biol Chem (2004) 0.75