Published in J Biol Chem on October 23, 2006
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer (2008) 4.71
Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood (2008) 2.09
Redox signaling in cardiac myocytes. Free Radic Biol Med (2011) 1.62
Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species. Chem Res Toxicol (2012) 1.51
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes (2008) 1.30
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. J Clin Invest (2013) 1.12
Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell (2012) 1.10
Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha. J Biol Chem (2008) 1.08
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem (2009) 1.08
The role of HIF prolyl hydroxylases in tumour growth. J Cell Mol Med (2010) 1.06
Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood (2008) 1.02
Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol (2007) 1.01
HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci (2008) 1.00
Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. Cancer Res (2013) 0.99
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99
Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells. PLoS One (2010) 0.98
Diabetic nephropathy: a disorder of oxygen metabolism? Nat Rev Nephrol (2009) 0.94
Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. J Neurosci Res (2008) 0.93
Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study. J Trauma Acute Care Surg (2012) 0.92
Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol (2013) 0.87
Role of nitric oxide in placental vascular development and function. Placenta (2011) 0.86
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis (2009) 0.86
Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells. Am J Physiol Cell Physiol (2008) 0.84
Imaging tumor hypoxia to advance radiation oncology. Antioxid Redox Signal (2014) 0.83
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma. Immunol Cell Biol (2009) 0.82
Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu. Immunology (2008) 0.82
Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells. World J Stem Cells (2015) 0.81
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology (2015) 0.81
Nitric oxide produced by cytochrome c oxidase helps stabilize HIF-1α in hypoxic mammalian cells. Biochem Biophys Res Commun (2012) 0.80
Increased endogenous nitric oxide release by iron chelation and purinergic activation in the rat carotid body. Open Biochem J (2007) 0.79
HIF-1alpha subunit and vasoactive HIF-1-dependent genes are involved in carbon monoxide-induced cerebral hypoxic stress response. Eur J Appl Physiol (2008) 0.79
Insights into the cellular responses to hypoxia in filamentous fungi. Curr Genet (2015) 0.78
The implications of hyponitroxia in cancer. Transl Oncol (2014) 0.76
Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury. Neural Regen Res (2012) 0.76
Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma. Oncotarget (2017) 0.75
Iron and restless legs syndrome: treatment, genetics and pathophysiology. Sleep Med (2016) 0.75
Partial Enteral Nutrition Mitigated Ischemia/Reperfusion-Induced Damage of Rat Small Intestinal Barrier. Nutrients (2016) 0.75
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J Cell Sci (2003) 2.46
Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study. Circulation (2010) 2.45
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J (2006) 2.13
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11
Altered pulmonary vascular reactivity in mice with excessive erythrocytosis. Am J Respir Crit Care Med (2003) 1.48
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest (2016) 1.42
Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol (2007) 1.29
The proinflammatory cytokine interleukin 1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells through hypoxia inducible factor 1 activation. Cancer Res (2005) 1.24
Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol (2006) 1.21
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood (2002) 1.11
Endovascular therapy of acute ischaemic stroke by interventional cardiologists: single-centre experience from Turkey. EuroIntervention (2014) 1.10
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem (2009) 1.08
NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells. Am J Physiol Cell Physiol (2002) 1.07
Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. J Am Coll Cardiol (2007) 1.07
Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem (2003) 1.06
Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem (2009) 1.04
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases. Cardiovasc Res (2006) 1.03
Hypoxia-induced erythropoietin expression in human neuroblastoma requires a methylation free HIF-1 binding site. J Cell Biochem (2004) 1.00
Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha. J Biol Chem (2004) 0.99
The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis. Anesthesiology (2013) 0.99
Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation. J Interferon Cytokine Res (2005) 0.98
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J Biol Chem (2004) 0.98
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res (2011) 0.95
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood (2012) 0.95
Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide. J Biol Chem (2008) 0.95
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res (2012) 0.94
Retracted Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC. Blood (2011) 0.94
Retracted Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance. J Immunol (2009) 0.92
Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression. News Physiol Sci (2000) 0.91
Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1. Thromb Haemost (2003) 0.89
Neural substrates for behaviorally conditioned immunosuppression in the rat. J Neurosci (2005) 0.89
Oxygen-sensing under the influence of nitric oxide. Cell Signal (2010) 0.89
Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis. Blood (2003) 0.88
Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. Endocrinology (2008) 0.88
Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies. Anesthesiology (2013) 0.87
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood (2012) 0.87
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis (2009) 0.86
Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells. Biol Chem (2013) 0.86
Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors. Biochem Biophys Res Commun (2009) 0.85
Optical analysis of the HIF-1 complex in living cells by FRET and FRAP. FASEB J (2006) 0.85
Thrombopoietin gene expression in the developing human central nervous system. Brain Res Dev Brain Res (2003) 0.85
Myeloid hypoxia-inducible factor-1α is essential for skeletal muscle regeneration in mice. J Immunol (2013) 0.85
Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1. Am J Physiol Regul Integr Comp Physiol (2004) 0.84
Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling. J Cell Sci (2012) 0.84
The HIF-1 response to simulated ischemia in mouse skeletal muscle cells neither enhances glycolysis nor prevents myotube cell death. Am J Physiol Regul Integr Comp Physiol (2007) 0.84
A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica (2014) 0.82
Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo. Am J Physiol Cell Physiol (2011) 0.80
Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. Br J Haematol (2014) 0.80
Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat. J Invest Surg (2010) 0.80
Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis. Br J Haematol (2002) 0.80
Molecular imaging: into in vivo interaction of HIF-1alpha and HIF-2alpha with ARNT. Ann N Y Acad Sci (2009) 0.79
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS One (2011) 0.79
Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures. Biol Chem (2004) 0.79
Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis. Anesthesiology (2016) 0.79
More insights into the CCN3/Connexin43 interaction complex and its role for signaling. J Cell Biochem (2010) 0.79
A cordial affair - erythropoietin and cardioprotection. Cardiovasc Res (2006) 0.78
Monitoring of cellular responses to hypoxia. Methods Mol Biol (2010) 0.77
The impact of N-nitrosomelatonin as nitric oxide donor in cell culture experiments. J Pineal Res (2008) 0.77
Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris. Shock (2011) 0.77
No evidence for protective erythropoietin alpha signalling in rat hepatocytes. BMC Gastroenterol (2009) 0.77
Measurement of ROS Levels and Membrane Potential Dynamics in the Intact Carotid Body Ex Vivo. Adv Exp Med Biol (2015) 0.77
Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signaling. Biol Chem (2010) 0.75
Nanoscopy of the cellular response to hypoxia by means of fluorescence resonance energy transfer (FRET) and new FRET software. PMC Biophys (2010) 0.75
Hypoxia induced gene expression: the specificity switch! Cell Cycle (2015) 0.75
Hypoxic pulmonary vasoconstriction is/is not mediated by increased production of reactive oxygen species. J Appl Physiol (1985) (2006) 0.75
Retraction: Hypoxia-Inducible Factor (HIF) 1α Accumulation and HIF Target Gene Expression Are Impaired after Induction of Endotoxin Tolerance. J Immunol (2017) 0.75
Two-photon imaging of cellular activities in oxygen sensing tissues. Microsc Microanal (2008) 0.75
Highlight: sensing hypoxia in the cell and the organism. Biol Chem (2013) 0.75
Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia. Onkologie (2005) 0.75
Oxygen and the cell. Biol Chem (2004) 0.75