Published in J Biol Chem on September 13, 2006
The twin-arginine translocation (Tat) protein export pathway. Nat Rev Microbiol (2012) 2.53
Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging. Proc Natl Acad Sci U S A (2008) 2.09
Co-operation between different targeting pathways during integration of a membrane protein. J Cell Biol (2012) 1.14
Following the path of a twin-arginine precursor along the TatABC translocase of Escherichia coli. J Biol Chem (2008) 1.13
Twin-arginine-dependent translocation of folded proteins. Philos Trans R Soc Lond B Biol Sci (2012) 1.09
TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli. FEBS Lett (2007) 1.06
Early contacts between substrate proteins and TatA translocase component in twin-arginine translocation. J Biol Chem (2011) 1.05
TatB functions as an oligomeric binding site for folded Tat precursor proteins. Mol Biol Cell (2010) 1.04
Visualizing interactions along the Escherichia coli twin-arginine translocation pathway using protein fragment complementation. PLoS One (2010) 0.99
Cysteine scanning mutagenesis and topological mapping of the Escherichia coli twin-arginine translocase TatC Component. J Bacteriol (2007) 0.98
Escherichia coli TatA and TatB proteins have N-out, C-in topology in intact cells. J Biol Chem (2012) 0.98
Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB. Nat Commun (2012) 0.91
Molecular dissection of TatC defines critical regions essential for protein transport and a TatB-TatC contact site. Mol Microbiol (2012) 0.91
Secretome of obligate intracellular Rickettsia. FEMS Microbiol Rev (2014) 0.89
Mechanistic Aspects of Folded Protein Transport by the Twin Arginine Translocase (Tat). J Biol Chem (2015) 0.87
Substrate-gated docking of pore subunit Tha4 in the TatC cavity initiates Tat translocase assembly. J Cell Biol (2014) 0.86
The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. Structure (2013) 0.86
Processing by rhomboid protease is required for Providencia stuartii TatA to interact with TatC and to form functional homo-oligomeric complexes. Mol Microbiol (2012) 0.84
Initial assembly steps of a translocase for folded proteins. Nat Commun (2015) 0.82
Twin-arginine translocation system in Helicobacter pylori: TatC, but not TatB, is essential for viability. MBio (2014) 0.80
Formation of functional Tat translocases from heterologous components. BMC Microbiol (2006) 0.79
A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase. Proc Natl Acad Sci U S A (2017) 0.77
YopN and TyeA Hydrophobic Contacts Required for Regulating Ysc-Yop Type III Secretion Activity by Yersinia pseudotuberculosis. Front Cell Infect Microbiol (2016) 0.75
Signal Peptide Hydrophobicity Modulates Interaction with the Twin-Arginine Translocase. MBio (2017) 0.75
Prediction of twin-arginine signal peptides. BMC Bioinformatics (2005) 3.03
Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocr Relat Cancer (2004) 3.03
Proline-induced distortions of transmembrane helices. J Mol Biol (2002) 2.76
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Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science (2010) 2.52
Liquid-vapor oscillations of water in hydrophobic nanopores. Proc Natl Acad Sci U S A (2003) 2.48
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Acquisition of siderophores in gram-negative bacteria. Nat Rev Mol Cell Biol (2003) 2.24
Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One (2008) 2.18
The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores. Phys Biol (2004) 2.13
Insertion and assembly of membrane proteins via simulation. J Am Chem Soc (2006) 2.12
Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging. Proc Natl Acad Sci U S A (2008) 2.09
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J (2010) 2.05
H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron (2007) 2.02
The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc Natl Acad Sci U S A (2005) 2.02
Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes. Mol Microbiol (2008) 1.99
Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res (2009) 1.98
Coarse-grained MD simulations of membrane protein-bilayer self-assembly. Structure (2008) 1.98
The Tat protein translocation pathway and its role in microbial physiology. Adv Microb Physiol (2003) 1.96
Role of the Escherichia coli Tat pathway in outer membrane integrity. Mol Microbiol (2003) 1.96
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer (2007) 1.94
The complex extracellular biology of Streptomyces. FEMS Microbiol Rev (2009) 1.94
Coarse-grained molecular dynamics simulations of membrane proteins and peptides. J Struct Biol (2006) 1.91
Membrane proteins: molecular dynamics simulations. Curr Opin Struct Biol (2008) 1.86
Setting up and optimization of membrane protein simulations. Eur Biophys J (2002) 1.79
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit. EMBO J (2005) 1.79
Protein targeting by the bacterial twin-arginine translocation (Tat) pathway. Curr Opin Microbiol (2005) 1.78
Secretion by numbers: Protein traffic in prokaryotes. Mol Microbiol (2006) 1.75
Properties of integral membrane protein structures: derivation of an implicit membrane potential. Proteins (2005) 1.74
Genetic analysis of the twin arginine translocator secretion pathway in bacteria. J Biol Chem (2002) 1.74
Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A (2005) 1.73
Coordinating assembly and export of complex bacterial proteins. EMBO J (2004) 1.73
Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst (2013) 1.70
A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor. Phys Biol (2006) 1.70
Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends Microbiol (2008) 1.69
3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. EMBO J (2005) 1.66
A photoactive carotenoid protein acting as light intensity sensor. Proc Natl Acad Sci U S A (2008) 1.62
A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease. Int J Cancer (2012) 1.60
Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations. Proc Natl Acad Sci U S A (2007) 1.59
How Escherichia coli is equipped to oxidize hydrogen under different redox conditions. J Biol Chem (2009) 1.59
The pore structure and gating mechanism of K2P channels. EMBO J (2011) 1.56
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
Molecular simulation approaches to membrane proteins. Structure (2011) 1.52
Coarse-grained molecular dynamics simulations of the energetics of helix insertion into a lipid bilayer. Biochemistry (2008) 1.51
Outer membrane protein G: Engineering a quiet pore for biosensing. Proc Natl Acad Sci U S A (2008) 1.48
Conserved network of proteins essential for bacterial viability. J Bacteriol (2009) 1.48
Behaviour of topological marker proteins targeted to the Tat protein transport pathway. Mol Microbiol (2002) 1.47
Membrane protein dynamics versus environment: simulations of OmpA in a micelle and in a bilayer. J Mol Biol (2003) 1.47
How does a voltage sensor interact with a lipid bilayer? Simulations of a potassium channel domain. Structure (2007) 1.46
Not ions alone: barriers to ion permeation in nanopores and channels. J Am Chem Soc (2004) 1.46
The structural basis of ZMPSTE24-dependent laminopathies. Science (2013) 1.43
Export of complex cofactor-containing proteins by the bacterial Tat pathway. Trends Microbiol (2005) 1.42
K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study. Biophys J (2002) 1.42
Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. EMBO J (2007) 1.41
Changes in transmembrane helix alignment by arginine residues revealed by solid-state NMR experiments and coarse-grained MD simulations. J Am Chem Soc (2010) 1.41
PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations. Biochemistry (2009) 1.40
Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel. EMBO Rep (2006) 1.39
Structure and dynamics of the membrane-bound cytochrome P450 2C9. PLoS Comput Biol (2011) 1.37
A subset of bacterial inner membrane proteins integrated by the twin-arginine translocase. Mol Microbiol (2003) 1.36
From in silico target prediction to multi-target drug design: current databases, methods and applications. J Proteomics (2011) 1.35
Complete ion-coordination structure in the rotor ring of Na+-dependent F-ATP synthases. J Mol Biol (2009) 1.34
The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor. Proc Natl Acad Sci U S A (2006) 1.34
Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway. J Bacteriol (2004) 1.34
Transmembrane helix prediction: a comparative evaluation and analysis. Protein Eng Des Sel (2005) 1.33
Structural determinants underlying photoprotection in the photoactive orange carotenoid protein of cyanobacteria. J Biol Chem (2010) 1.33
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. EMBO Rep (2005) 1.32
Viral ion channels: structure and function. Biochim Biophys Acta (2002) 1.31
Conformational sampling and dynamics of membrane proteins from 10-nanosecond computer simulations. Proteins (2004) 1.31
Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. J Chem Inf Model (2012) 1.29
Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A (2009) 1.29
Stable-isotope labeling with amino acids in nematodes. Nat Methods (2011) 1.28
Export pathway selectivity of Escherichia coli twin arginine translocation signal peptides. J Biol Chem (2007) 1.28
Oligomeric properties and signal peptide binding by Escherichia coli Tat protein transport complexes. J Mol Biol (2002) 1.28
OmpA: a pore or not a pore? Simulation and modeling studies. Biophys J (2002) 1.28
In vivo dissection of the Tat translocation pathway in Escherichia coli. J Mol Biol (2002) 1.28
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. J Gen Physiol (2008) 1.28
Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica. Microbiology (2002) 1.28
Coarse-grained simulation: a high-throughput computational approach to membrane proteins. Biochem Soc Trans (2008) 1.25
Analysis and evaluation of channel models: simulations of alamethicin. Biophys J (2002) 1.25
The selectivity of K+ ion channels: testing the hypotheses. Biophys J (2008) 1.24
Characterization and membrane assembly of the TatA component of the Escherichia coli twin-arginine protein transport system. Biochemistry (2002) 1.24
Structure of the TatC core of the twin-arginine protein transport system. Nature (2012) 1.23