Molecular dissection of TatC defines critical regions essential for protein transport and a TatB-TatC contact site.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3712464)

Published in Mol Microbiol on July 13, 2012

Authors

Holger Kneuper1, Barbara Maldonado, Franziska Jäger, Martin Krehenbrink, Grant Buchanan, Rebecca Keller, Matthias Müller, Ben C Berks, Tracy Palmer

Author Affiliations

1: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Articles citing this

Structure of the TatC core of the twin-arginine protein transport system. Nature (2012) 1.23

Mapping the signal peptide binding and oligomer contact sites of the core subunit of the pea twin arginine protein translocase. Plant Cell (2013) 1.11

Channel crossing: how are proteins shipped across the bacterial plasma membrane? Philos Trans R Soc Lond B Biol Sci (2015) 0.92

Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB. Nat Commun (2012) 0.91

Substrate-dependent assembly of the Tat translocase as observed in live Escherichia coli cells. PLoS One (2013) 0.91

Mechanistic Aspects of Folded Protein Transport by the Twin Arginine Translocase (Tat). J Biol Chem (2015) 0.87

Substrate-gated docking of pore subunit Tha4 in the TatC cavity initiates Tat translocase assembly. J Cell Biol (2014) 0.86

The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. Structure (2013) 0.86

Initial assembly steps of a translocase for folded proteins. Nat Commun (2015) 0.82

The TatC component of the twin-arginine protein translocase functions as an obligate oligomer. Mol Microbiol (2015) 0.79

Identification and evaluation of twin-arginine translocase inhibitors. Antimicrob Agents Chemother (2012) 0.78

A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase. Proc Natl Acad Sci U S A (2017) 0.77

Assembling the Tat protein translocase. Elife (2016) 0.76

Diversity and evolution of bacterial twin arginine translocase protein, TatC, reveals a protein secretion system that is evolving to fit its environmental niche. PLoS One (2013) 0.76

Signal Peptide Hydrophobicity Modulates Interaction with the Twin-Arginine Translocase. MBio (2017) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics (2005) 34.83

Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences. Proc Natl Acad Sci U S A (1979) 22.59

The Jpred 3 secondary structure prediction server. Nucleic Acids Res (2008) 13.32

X-ray structure of a protein-conducting channel. Nature (2003) 9.20

A common export pathway for proteins binding complex redox cofactors? Mol Microbiol (1996) 5.00

Protein translocation across the bacterial cytoplasmic membrane. Annu Rev Biochem (2008) 4.07

Overlapping functions of components of a bacterial Sec-independent protein export pathway. EMBO J (1998) 3.59

A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. Cell (1998) 3.33

An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria. J Biol Chem (1998) 2.86

Proline-induced distortions of transmembrane helices. J Mol Biol (2002) 2.76

The twin-arginine translocation (Tat) protein export pathway. Nat Rev Microbiol (2012) 2.53

Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction. Anal Biochem (1995) 2.39

Differential interactions between a twin-arginine signal peptide and its translocase in Escherichia coli. Mol Cell (2003) 2.35

Sec-independent protein translocation in Escherichia coli. A distinct and pivotal role for the TatB protein. J Biol Chem (1999) 2.21

Thylakoid DeltapH-dependent precursor proteins bind to a cpTatC-Hcf106 complex before Tha4-dependent transport. J Cell Biol (2001) 2.17

TatB and TatC form a functional and structural unit of the twin-arginine translocase from Escherichia coli. J Biol Chem (2001) 2.11

TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. J Biol Chem (2000) 2.10

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging. Proc Natl Acad Sci U S A (2008) 2.09

Sec-independent protein translocation by the maize Hcf106 protein. Science (1997) 2.09

The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc Natl Acad Sci U S A (2005) 2.02

Role of the Escherichia coli Tat pathway in outer membrane integrity. Mol Microbiol (2003) 1.96

Hypermutagenic PCR involving all four transitions and a sizeable proportion of transversions. Nucleic Acids Res (1996) 1.67

Two minimal Tat translocases in Bacillus. Mol Microbiol (2004) 1.58

Purified components of the Escherichia coli Tat protein transport system form a double-layered ring structure. Eur J Biochem (2001) 1.55

Oligomers of Tha4 organize at the thylakoid Tat translocase during protein transport. J Biol Chem (2005) 1.51

A set of temperature sensitive-replication/-segregation and temperature resistant plasmid vectors with different copy numbers and in an isogenic background (chloramphenicol, kanamycin, lacZ, repA, par, polA). Gene (2000) 1.35

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A (2009) 1.29

Oligomeric properties and signal peptide binding by Escherichia coli Tat protein transport complexes. J Mol Biol (2002) 1.28

Constitutive expression of Escherichia coli tat genes indicates an important role for the twin-arginine translocase during aerobic and anaerobic growth. J Bacteriol (2001) 1.27

Efficient twin arginine translocation (Tat) pathway transport of a precursor protein covalently anchored to its initial cpTatC binding site. J Biol Chem (2005) 1.23

Targeting of unfolded PhoA to the TAT translocon of Escherichia coli. J Biol Chem (2005) 1.21

Functional complexity of the twin-arginine translocase TatC component revealed by site-directed mutagenesis. Mol Microbiol (2002) 1.21

Separate analysis of twin-arginine translocation (Tat)-specific membrane binding and translocation in Escherichia coli. J Biol Chem (2002) 1.14

Cysteine-scanning mutagenesis and disulfide mapping studies of the conserved domain of the twin-arginine translocase TatB component. J Biol Chem (2006) 1.12

Clustering of C-terminal stromal domains of Tha4 homo-oligomers during translocation by the Tat protein transport system. Mol Biol Cell (2009) 1.12

Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis. J Am Chem Soc (2010) 1.10

Escherichia coli twin arginine (Tat) mutant translocases possessing relaxed signal peptide recognition specificities. J Biol Chem (2007) 1.09

Twin-arginine-dependent translocation of folded proteins. Philos Trans R Soc Lond B Biol Sci (2012) 1.09

Bifunctional TatA subunits in minimal Tat protein translocases. Trends Microbiol (2005) 1.08

The entire N-terminal half of TatC is involved in twin-arginine precursor binding. Biochemistry (2007) 1.07

The inducible trimethylamine-N-oxide reductase of Escherichia coli K12: biochemical and immunological studies. Biochim Biophys Acta (1988) 1.07

Multiple precursor proteins bind individual Tat receptor complexes and are collectively transported. EMBO J (2010) 1.05

Escherichia coli tatC mutations that suppress defective twin-arginine transporter signal peptides. J Mol Biol (2007) 1.01

Mapping precursor-binding site on TatC subunit of twin arginine-specific protein translocase by site-specific photo cross-linking. J Biol Chem (2012) 1.00

Consensus structural features of purified bacterial TatABC complexes. J Mol Biol (2003) 0.99

TMKink: a method to predict transmembrane helix kinks. Protein Sci (2011) 0.98

Cysteine scanning mutagenesis and topological mapping of the Escherichia coli twin-arginine translocase TatC Component. J Bacteriol (2007) 0.98

Characterisation of Tat protein transport complexes carrying inactivating mutations. Biochem Biophys Res Commun (2005) 0.95

Genetic evidence for a TatC dimer at the core of the Escherichia coli twin arginine (Tat) protein translocase. J Mol Microbiol Biotechnol (2011) 0.92

Essential cytoplasmic domains in the Escherichia coli TatC protein. J Biol Chem (2002) 0.92

Mutations in subunits of the Escherichia coli twin-arginine translocase block function via differing effects on translocation activity or tat complex structure. J Mol Biol (2005) 0.91

Analysis of Tat targeting function and twin-arginine signal peptide activity in Escherichia coli. Methods Mol Biol (2010) 0.90

Characterisation of the membrane-extrinsic domain of the TatB component of the twin arginine protein translocase. FEBS Lett (2011) 0.86

Processing by rhomboid protease is required for Providencia stuartii TatA to interact with TatC and to form functional homo-oligomeric complexes. Mol Microbiol (2012) 0.84

Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase. FEBS J (2005) 0.83

Articles by these authors

Prediction of twin-arginine signal peptides. BMC Bioinformatics (2005) 3.03

Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocr Relat Cancer (2004) 3.03

Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron (2006) 2.53

The twin-arginine translocation (Tat) protein export pathway. Nat Rev Microbiol (2012) 2.53

Differential interactions between a twin-arginine signal peptide and its translocase in Escherichia coli. Mol Cell (2003) 2.35

Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One (2008) 2.18

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging. Proc Natl Acad Sci U S A (2008) 2.09

Fifteen-year single center experience with the "Giessen Hybrid" approach for hypoplastic left heart and variants: current strategies and outcomes. Pediatr Cardiol (2014) 2.08

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood (2005) 2.07

Pulmonary artery banding in infants and young children with left ventricular dilated cardiomyopathy: a novel therapeutic strategy before heart transplantation. J Heart Lung Transplant (2013) 2.06

The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc Natl Acad Sci U S A (2005) 2.02

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes. Mol Microbiol (2008) 1.99

Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res (2009) 1.98

The Tat protein translocation pathway and its role in microbial physiology. Adv Microb Physiol (2003) 1.96

Role of the Escherichia coli Tat pathway in outer membrane integrity. Mol Microbiol (2003) 1.96

Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer (2007) 1.94

The complex extracellular biology of Streptomyces. FEMS Microbiol Rev (2009) 1.94

Protein targeting by the bacterial twin-arginine translocation (Tat) pathway. Curr Opin Microbiol (2005) 1.78

Secretion by numbers: Protein traffic in prokaryotes. Mol Microbiol (2006) 1.75

Impact of working memory training on memory performance in old-old adults. Psychol Aging (2008) 1.74

Genetic analysis of the twin arginine translocator secretion pathway in bacteria. J Biol Chem (2002) 1.74

Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A (2005) 1.73

Coordinating assembly and export of complex bacterial proteins. EMBO J (2004) 1.73

Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst (2013) 1.70

Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends Microbiol (2008) 1.69

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66

A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease. Int J Cancer (2012) 1.60

How Escherichia coli is equipped to oxidize hydrogen under different redox conditions. J Biol Chem (2009) 1.59

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc Natl Acad Sci U S A (2004) 1.58

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol (2011) 1.56

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation. Arthritis Rheum (2009) 1.52

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors. Cancer Res (2011) 1.52

First clinical results of the Locking Compression Plate (LCP). Injury (2003) 1.50

Conserved network of proteins essential for bacterial viability. J Bacteriol (2009) 1.48

Behaviour of topological marker proteins targeted to the Tat protein transport pathway. Mol Microbiol (2002) 1.47

Dynamics of medial smooth muscle changes after carotid artery transplantation in transgenic mice expressing green fluorescent protein. Transplantation (2003) 1.43

Export of complex cofactor-containing proteins by the bacterial Tat pathway. Trends Microbiol (2005) 1.42

A subset of bacterial inner membrane proteins integrated by the twin-arginine translocase. Mol Microbiol (2003) 1.36

Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway. J Bacteriol (2004) 1.34

The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor. Proc Natl Acad Sci U S A (2006) 1.34

Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J Cell Sci (2011) 1.30

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A (2009) 1.29

New insights into paracrine mechanisms of human cardiac progenitor cells. Eur J Heart Fail (2010) 1.29

Export pathway selectivity of Escherichia coli twin arginine translocation signal peptides. J Biol Chem (2007) 1.28

Stable-isotope labeling with amino acids in nematodes. Nat Methods (2011) 1.28

Oligomeric properties and signal peptide binding by Escherichia coli Tat protein transport complexes. J Mol Biol (2002) 1.28

In vivo dissection of the Tat translocation pathway in Escherichia coli. J Mol Biol (2002) 1.28

Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica. Microbiology (2002) 1.28

Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement. Genesis (2005) 1.25

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone. J Bone Miner Res (2011) 1.25

Characterization and membrane assembly of the TatA component of the Escherichia coli twin-arginine protein transport system. Biochemistry (2002) 1.24

Structure of the TatC core of the twin-arginine protein transport system. Nature (2012) 1.23

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology (2009) 1.22

Functional complexity of the twin-arginine translocase TatC component revealed by site-directed mutagenesis. Mol Microbiol (2002) 1.21

Glucomannan-mediated attachment of Rhizobium leguminosarum to pea root hairs is required for competitive nodule infection. J Bacteriol (2008) 1.20

Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer. FASEB J (2007) 1.19

Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme. EMBO J (2002) 1.19

IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. J Biol Chem (2007) 1.19

In vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed (2007) 1.18

The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm. J Biol Chem (2007) 1.17

Cysteine scanning mutagenesis and disulfide mapping studies of the TatA component of the bacterial twin arginine translocase. J Biol Chem (2007) 1.16

Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins. FEMS Microbiol Lett (2006) 1.16

Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Eur J Clin Pharmacol (2004) 1.16

Novel phenotypes of Escherichia coli tat mutants revealed by global gene expression and phenotypic analysis. J Biol Chem (2004) 1.15

Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer (2007) 1.15

Separate analysis of twin-arginine translocation (Tat)-specific membrane binding and translocation in Escherichia coli. J Biol Chem (2002) 1.14

Co-operation between different targeting pathways during integration of a membrane protein. J Cell Biol (2012) 1.14

Ingestion of colostrum from specific cows induces Bovine Neonatal Pancytopenia (BNP) in some calves. BMC Vet Res (2011) 1.13

Following the path of a twin-arginine precursor along the TatABC translocase of Escherichia coli. J Biol Chem (2008) 1.13

Cysteine-scanning mutagenesis and disulfide mapping studies of the conserved domain of the twin-arginine translocase TatB component. J Biol Chem (2006) 1.12

Signal integration by the Cpx-envelope stress system. FEMS Microbiol Lett (2011) 1.12

The Escherichia coli cell division protein and model Tat substrate SufI (FtsP) localizes to the septal ring and has a multicopper oxidase-like structure. J Mol Biol (2008) 1.11

Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. J Biol Chem (2002) 1.10

Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS J (2006) 1.09

Twin-arginine-dependent translocation of folded proteins. Philos Trans R Soc Lond B Biol Sci (2012) 1.09