Published in Neuron on September 21, 2006
GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol (2007) 2.80
Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci (2009) 2.73
Microtubule stabilization specifies initial neuronal polarization. J Cell Biol (2008) 2.60
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog (2009) 2.29
Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol (2010) 2.17
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am J Hum Genet (2011) 1.58
Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons. J Neurosci (2009) 1.48
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
Neuronal polarity. Cold Spring Harb Perspect Biol (2009) 1.42
Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics (2007) 1.42
ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol (2008) 1.37
New insights into the molecular mechanisms specifying neuronal polarity in vivo. Curr Opin Neurobiol (2008) 1.25
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci (2012) 1.22
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Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex. Small GTPases (2011) 1.19
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity. Mol Biol Cell (2010) 1.17
Insights into the biological functions of Dock family guanine nucleotide exchange factors. Genes Dev (2014) 1.15
Localized activation of p21-activated kinase controls neuronal polarity and morphology. J Neurosci (2007) 1.15
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem (2011) 1.10
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A (2008) 1.07
Role of T198 modification in the regulation of p27(Kip1) protein stability and function. PLoS One (2011) 1.04
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem (2010) 1.04
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc Natl Acad Sci U S A (2009) 1.01
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One (2008) 1.01
Altered thermogenesis and impaired bone remodeling in Misty mice. J Bone Miner Res (2013) 0.99
Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development. J Biol Chem (2009) 0.97
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Microtubule dynamics in neuronal morphogenesis. Open Biol (2013) 0.94
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Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell (2008) 0.90
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J Cell Biol (2012) 0.90
Regulation of chandelier cell cartridge and bouton development via DOCK7-mediated ErbB4 activation. Cell Rep (2014) 0.90
ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions. J Biol Chem (2012) 0.89
The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell (2008) 0.89
Stathmin is required for stability of the Drosophila neuromuscular junction. J Neurosci (2011) 0.89
Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Biochem J (2008) 0.89
Apoptotic cell recognition receptors and scavenger receptors. Immunol Rev (2016) 0.87
Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. AAPS J (2010) 0.86
Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness. Am J Hum Genet (2014) 0.85
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Rho-guanine nucleotide exchange factors during development: Force is nothing without control. Small GTPases (2010) 0.85
Evidence for the involvement of Lfc and Tctex-1 in axon formation. J Neurosci (2010) 0.85
Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. Biochemistry (2013) 0.84
Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol (2008) 0.83
Rac1 modulates stimulus-evoked Ca(2+) release in neuronal growth cones via parallel effects on microtubule/endoplasmic reticulum dynamics and reactive oxygen species production. Mol Biol Cell (2009) 0.83
Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev (2013) 0.83
The cytoskeleton and neurite initiation. Bioarchitecture (2014) 0.83
Nervous Rac: DOCK7 regulation of axon formation. Neuron (2006) 0.82
Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction. Cell Adh Migr (2009) 0.82
Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons. Cereb Cortex (2014) 0.82
The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases. Front Cell Neurosci (2014) 0.81
Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs. Biomed Res Int (2015) 0.81
The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. Small GTPases (2012) 0.79
Neuronal polarization in the developing cerebral cortex. Front Neurosci (2015) 0.79
The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics. J Biol Chem (2013) 0.78
Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells. Biol Open (2014) 0.77
Zizimin and Dock guanine nucleotide exchange factors in cell function and disease. Small GTPases (2012) 0.77
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells. Biol Open (2015) 0.77
Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia. J Cell Mol Med (2015) 0.77
Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons. J Biol Chem (2012) 0.76
Identification of microtubule growth deceleration and its regulation by conserved and novel proteins. Mol Biol Cell (2016) 0.76
Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation. Br J Cancer (2014) 0.76
Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system. Biochem J (2016) 0.76
Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet (2016) 0.75
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PLoS One (2016) 0.75
Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone (2017) 0.75
Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks. Front Cell Neurosci (2017) 0.75
Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev (2002) 4.80
Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell (2002) 4.50
The role of the Rho GTPases in neuronal development. Genes Dev (2005) 4.47
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci (2004) 2.26
Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19
Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68
The role of Rho GTPases in disease development. Gene (2002) 1.51
Rho-linked genes and neurological disorders. Pflugers Arch (2007) 1.39
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev (2009) 1.35
The role of Rho GTPase proteins in CNS neuronal migration. Dev Neurobiol (2011) 1.28
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics (2003) 1.27
Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med (2004) 1.23
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci (2012) 1.22
Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol (2006) 1.22
Regulators of Rho GTPases in neuronal development. J Neurosci (2006) 1.11
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem (2011) 1.10
Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J Neurosci (2010) 1.08
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol (2007) 1.06
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol (2006) 1.05
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1. Curr Biol (2009) 1.05
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells. Blood (2006) 1.01
Association of syncoilin and desmin: linking intermediate filament proteins to the dystrophin-associated protein complex. J Biol Chem (2001) 1.00
Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery. Neuron (2011) 0.98
The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. Stem Cells Dev (2009) 0.95
Genetically encoded proton sensors reveal activity-dependent pH changes in neurons. Front Mol Neurosci (2012) 0.93
The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. J Physiol (2011) 0.92
Characterization of oligophrenin-1, a RhoGAP lost in patients affected with mental retardation: lentiviral injection in organotypic brain slice cultures. Methods Enzymol (2008) 0.89
A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system. Front Cell Neurosci (2013) 0.88
Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation. Mol Cell Biol (2011) 0.87
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS One (2013) 0.86
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest (2015) 0.84
Dialogue between RhoA/ROCK and members of the Par complex in cell polarity. Dev Cell (2008) 0.81
Microvessel networks [corrected] pre-formed in artificial clinical grade dermal substitutes in vitro using cells from haematopoietic tissues. Burns (2012) 0.79
The RASputin effect. Genes Dev (2002) 0.79
Driving actin dynamics under the influence of alcohol. Cell (2006) 0.78
DOK2 inhibits EGFR-mutated lung adenocarcinoma. PLoS One (2013) 0.78
Signaling mechanisms. Curr Opin Neurobiol (2010) 0.75
Using cDNA-representational difference analysis (cDNA-RDA) in combination with microarrays to identify Rac regulated genes. Methods Mol Biol (2002) 0.75
Introduction to the ECR special issue on the roles of small GTPases. Exp Cell Res (2013) 0.75
Signaling and gradients: what's going down? Curr Opin Cell Biol (2012) 0.75