Published in J Clin Invest on July 27, 2015
The metal face of protein tyrosine phosphatase 1B. Coord Chem Rev (2016) 0.78
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy? Front Aging Neurosci (2017) 0.77
PTP1B: a new therapeutic target for Rett syndrome. J Clin Invest (2015) 0.77
Systemic Radical Scavenger Treatment of a Mouse Model of Rett Syndrome: Merits and Limitations of the Vitamin E Derivative Trolox. Front Cell Neurosci (2016) 0.76
Characterization of PTP1B Inhibition by Chlorogenic Acid and Cichoric Acid. Biochemistry (2016) 0.75
Novel therapeutic approaches: Rett syndrome and human induced pluripotent stem cell technology. Stem Cell Investig (2017) 0.75
Leveraging reciprocity to identify and characterize unknown allosteric sites in protein tyrosine phosphatases. J Mol Biol (2017) 0.75
Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. Dev Cell (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet (1999) 22.84
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet (2001) 9.82
The story of Rett syndrome: from clinic to neurobiology. Neuron (2007) 8.08
AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res (2007) 6.36
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem (2002) 6.36
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci U S A (1997) 5.63
Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol (2002) 4.94
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A (2009) 3.23
TrkB signalling pathways in LTP and learning. Nat Rev Neurosci (2009) 3.12
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med (2013) 3.07
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am J Hum Genet (2014) 2.84
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet (2013) 2.59
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol (2012) 2.42
Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron (2008) 2.36
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem (2000) 2.32
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell (2000) 2.32
Activity-dependent neuronal signalling and autism spectrum disorder. Nature (2013) 2.23
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.91
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell (2013) 1.80
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68
Preclinical research in Rett syndrome: setting the foundation for translational success. Dis Model Mech (2012) 1.66
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry (2014) 1.62
The neurotrophin family of neurotrophic factors: an overview. Methods Mol Biol (2012) 1.51
Rett syndrome and plasma leptin levels. J Pediatr (2007) 1.44
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nat Chem Biol (2014) 1.40
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2012) 1.40
Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum Mol Genet (2011) 1.39
BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol (2014) 1.34
Parallel neural pathways mediate CO2 avoidance responses in Drosophila. Science (2013) 1.34
Rett syndrome diagnostic criteria: lessons from the Natural History Study. Ann Neurol (2010) 1.33
Leptin: a diverse regulator of neuronal function. J Neurochem (2006) 1.32
Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations. Curr Opin Neurol (2001) 1.30
Insulin receptor signaling in the development of neuronal structure and function. Neural Dev (2010) 1.29
Insulin in the brain: there and back again. Pharmacol Ther (2012) 1.25
Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochim Biophys Acta (2006) 1.23
β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2014) 1.23
Categorical perception of mouse pup ultrasound by lactating females. Naturwissenschaften (1981) 1.22
Ultrasonic communication in rodents. Nature (1970) 1.16
Multisensory integration of natural odors and sounds in the auditory cortex. Neuron (2011) 1.16
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet (2013) 1.15
Sex and parental experience determine the onset of an instinctive behavior in mice. Naturwissenschaften (1987) 1.15
Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met. Curr Opin Neurobiol (2011) 1.12
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J Biol Chem (2000) 1.12
MECP2 mutations in males. J Med Genet (2007) 1.05
The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase. J Biol Chem (2001) 0.96
MeCP2: the long trip from a chromatin protein to neurological disorders. Trends Mol Med (2014) 0.96
Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci (2013) 0.96
Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. EMBO J (2003) 0.94
A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. Dis Model Mech (2014) 0.94
Role of MeCP2, DNA methylation, and HDACs in regulating synapse function. J Neurodev Disord (2011) 0.88
Autism and dietary therapy: case report and review of the literature. J Child Neurol (2013) 0.87
Brain-derived neurotrophic factor and Rett syndrome. Handb Exp Pharmacol (2014) 0.87
Neurotrophic factors in the pathogenesis of Rett syndrome. J Child Neurol (2003) 0.85
Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome. Biochem Soc Trans (2014) 0.84
Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PLoS One (2012) 0.84
Abnormalities of thyroid function and glucose control in subjects with Rett syndrome. Horm Res (1995) 0.82
Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. J Biol Chem (2014) 0.81
Long-term plasma levels of leptin and adiponectin in Rett syndrome. Clin Endocrinol (Oxf) (2008) 0.81
Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives. Curr Clin Pharmacol (2013) 0.80
Neurotrophic factors in cerebrospinal fluid and serum of patients with Rett syndrome. J Child Neurol (1998) 0.79
Neuroscience. Path to treat Rett syndrome. Science (2013) 0.78
Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis. J Nat Med (2013) 0.76
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell (2002) 5.41
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60
Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell (2002) 4.50
The role of the Rho GTPases in neuronal development. Genes Dev (2005) 4.47
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med (2013) 3.07
Reactive oxygen species enhance insulin sensitivity. Cell Metab (2009) 2.77
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal (2011) 2.70
Representation of natural stimuli in the rodent main olfactory bulb. Neuron (2006) 2.70
The extended PP1 toolkit: designed to create specificity. Trends Biochem Sci (2010) 2.51
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron (2006) 2.49
Antitoxin MqsA helps mediate the bacterial general stress response. Nat Chem Biol (2011) 2.30
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci (2004) 2.26
Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19
Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost. Protein Expr Purif (2006) 2.02
Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure (2010) 1.89
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J (2004) 1.88
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem (2004) 1.81
Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68
A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol (2012) 1.67
Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog (2009) 1.65
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A (2008) 1.58
YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport. J Bacteriol (2006) 1.58
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem (2002) 1.57
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol (2010) 1.56
The role of Rho GTPases in disease development. Gene (2002) 1.51
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ Microbiol (2010) 1.46
Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus. J Biol Chem (2007) 1.44
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol Cell Biol (2003) 1.44
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol (2005) 1.41
Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. J Mol Biol (2004) 1.40
Rho-linked genes and neurological disorders. Pflugers Arch (2007) 1.39
Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells. FEBS J (2007) 1.39
Structure and function of the Escherichia coli protein YmgB: a protein critical for biofilm formation and acid-resistance. J Mol Biol (2007) 1.38
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors. J Mol Biol (2008) 1.38
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun (2007) 1.36
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev (2009) 1.35
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell (2011) 1.34
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
The role of Rho GTPase proteins in CNS neuronal migration. Dev Neurobiol (2011) 1.28
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics (2003) 1.27
Structural basis for protein phosphatase 1 regulation and specificity. FEBS J (2012) 1.26
State and neuronal class-dependent reconfiguration in the avian song system. J Neurophysiol (2003) 1.24
Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med (2004) 1.23
NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline. Proc Natl Acad Sci U S A (2005) 1.23
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci (2012) 1.22
Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol (2006) 1.22
The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. PLoS Biol (2013) 1.21
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. J Biol Chem (2003) 1.19
Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins (2004) 1.17
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16
Molecular basis of MAP kinase regulation. Protein Sci (2013) 1.15
Detailed structural characterization of unbound protein phosphatase 1 inhibitors. Biochemistry (2008) 1.14
NMR structure determination of the hypothetical protein TM1290 from Thermotoga maritima using automated NOESY analysis. J Biomol NMR (2004) 1.13
Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR. J Struct Funct Genomics (2005) 1.13
Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach. J Mol Biol (2013) 1.12
Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. J Biol Chem (2008) 1.12
Regulators of Rho GTPases in neuronal development. J Neurosci (2006) 1.11
Structural basis of p38α regulation by hematopoietic tyrosine phosphatase. Nat Chem Biol (2011) 1.11
Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity. J Biol Chem (2010) 1.11
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J Biol Chem (2010) 1.11
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem (2011) 1.10
Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia. Am J Pathol (2005) 1.10
Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. Proteins (2004) 1.09
Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J Neurosci (2010) 1.08
NMR assignment of the conserved hypothetical protein TM1290 of Thermotoga maritima. J Biomol NMR (2003) 1.08
Strategies to optimize protein expression in E. coli. Curr Protoc Protein Sci (2010) 1.07
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev (2011) 1.06
Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. Circ Res (2008) 1.06
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol (2007) 1.06
The conserved immunoglobulin domain controls the subcellular localization of the homophilic adhesion receptor protein-tyrosine phosphatase mu. J Biol Chem (2004) 1.05
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol (2006) 1.05
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1. Curr Biol (2009) 1.05
Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol (2005) 1.04
Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environ Microbiol (2013) 1.03
Engineering a novel c-di-GMP-binding protein for biofilm dispersal. Environ Microbiol (2010) 1.02
Self-consistency analysis of dipolar couplings in multiple alignments of ubiquitin. J Am Chem Soc (2003) 1.01
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site. J Mol Biol (2005) 1.00
Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution. Proteins (2004) 1.00
The NLRP12 pyrin domain: structure, dynamics, and functional insights. J Mol Biol (2011) 1.00
Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. J Biol Chem (2006) 0.99
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development (2002) 0.99
Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo. Methods (2005) 0.99