Published in Genetics on September 01, 2003
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80
The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. J Cell Biol (2009) 1.90
Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7. J Neurosci (2008) 1.44
Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. Mol Biol Cell (2009) 1.33
Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. J Cell Biol (2011) 1.14
New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microbes Infect (2011) 1.14
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol (2007) 1.06
The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled. PLoS One (2006) 0.96
The small GTPase Rap1 is a modulator of Hedgehog signaling. Dev Biol (2015) 0.94
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. J Cell Biol (2011) 0.92
Distinct Rap1 activity states control the extent of epithelial invagination via α-catenin. Dev Cell (2013) 0.90
Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol (2009) 0.90
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood (2010) 0.88
Talin autoinhibition is required for morphogenesis. Curr Biol (2013) 0.88
The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. Mol Biol Cell (2011) 0.87
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Mol Biol Cell (2004) 0.86
Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Mol Biol Cell (2013) 0.86
Under construction: building the macromolecular superstructure and signaling components of an electrical synapse. J Membr Biol (2012) 0.83
The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye. Development (2009) 0.82
Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila. Elife (2015) 0.81
Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila. Dev Biol (2012) 0.80
A functional genomic screen combined with time-lapse microscopy uncovers a novel set of genes involved in dorsal closure of Drosophila embryos. PLoS One (2011) 0.78
Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex. Protein Sci (2007) 0.78
Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature. PLoS One (2015) 0.77
Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge. Genetics (2015) 0.77
A big new job for small GTPases. Small GTPases (2012) 0.76
Retracted Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology. Am J Physiol Renal Physiol (2013) 0.76
Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium. PLoS One (2014) 0.76
Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1. Genetics (2014) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
A ras-related gene with transformation suppressor activity. Cell (1989) 5.81
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (1998) 4.62
Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell (2002) 4.50
Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol (2001) 3.36
The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J Cell Biol (2000) 2.72
RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J (1993) 2.38
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) Nature (1999) 2.23
Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science (2002) 2.09
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol (2003) 2.07
Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem (1999) 1.86
The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr Biol (2000) 1.86
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl Acad Sci U S A (2000) 1.68
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. J Cell Sci (2003) 1.66
Stress signaling in Drosophila. Oncogene (1999) 1.56
Ras and Rap1: two highly related small GTPases with distinct function. Exp Cell Res (1999) 1.43
The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J (1999) 1.42
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci (2001) 1.41
Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J Cell Sci (1999) 1.37
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. J Biol Chem (1999) 1.36
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N). Oncogene (1997) 1.36
Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A. Science (1991) 1.33
The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol (1999) 1.33
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. J Biol Chem (1999) 1.30
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J (1998) 1.16
Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes. J Biol Chem (1994) 1.10
Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye. Development (1997) 1.03
Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion. J Biol Chem (2000) 0.99
Two-hybrid analysis of Ras-Raf interactions. Methods Mol Biol (1998) 0.89
Ras and Rap1 interaction with AF-6 effector target. Methods Enzymol (2001) 0.88
MicroRNA targets in Drosophila. Genome Biol (2003) 23.59
The role of site accessibility in microRNA target recognition. Nat Genet (2007) 18.52
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64
Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature (2008) 5.08
Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell (2002) 4.50
The role of the Rho GTPases in neuronal development. Genes Dev (2005) 4.47
Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol (2003) 3.95
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development. Cell (2005) 3.95
Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo. BMC Bioinformatics (2002) 3.61
Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron (2006) 2.49
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci (2004) 2.26
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA (2004) 2.21
Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. J Cell Biol (2009) 1.90
Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron (2005) 1.90
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila. BMC Bioinformatics (2004) 1.82
RNAa is conserved in mammalian cells. PLoS One (2010) 1.81
GPCR signaling is required for blood-brain barrier formation in drosophila. Cell (2005) 1.70
moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell (2005) 1.69
MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway. Hepatology (2013) 1.69
Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68
The role of Rho GTPases in disease development. Gene (2002) 1.51
Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons. Cell (2008) 1.48
miR-184 has multiple roles in Drosophila female germline development. Dev Cell (2009) 1.46
Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res (2011) 1.46
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. J Neurosci (2008) 1.42
Rho-linked genes and neurological disorders. Pflugers Arch (2007) 1.39
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev (2009) 1.35
Comparing independent microarray studies: the case of human embryonic stem cells. BMC Genomics (2005) 1.35
Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res (2010) 1.31
The role of Rho GTPase proteins in CNS neuronal migration. Dev Neurobiol (2011) 1.28
Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med (2004) 1.23
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci (2012) 1.22
Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol (2006) 1.22
Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors. Neuron (2003) 1.21
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability. Hepatology (2013) 1.14
Regulators of Rho GTPases in neuronal development. J Neurosci (2006) 1.11
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem (2011) 1.10
Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J Neurosci (2010) 1.08
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol (2007) 1.06
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol (2006) 1.05
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1. Curr Biol (2009) 1.05
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts. Proc Natl Acad Sci U S A (2006) 1.02
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Overexpression of Cdx2 inhibits progression of gastric cancer in vitro. Int J Oncol (2010) 1.00
Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma. Hepatology (2013) 0.98
Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery. Neuron (2011) 0.98
The Escherichia coli argU10(Ts) phenotype is caused by a reduction in the cellular level of the argU tRNA for the rare codons AGA and AGG. J Bacteriol (2004) 0.97
Low stability of Huntington muscle mitochondria against Ca2+ in R6/2 mice. Ann Neurol (2006) 0.97
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol (2006) 0.95
A comparison of voluntary counseling and testing uptake between a China CARES county and a county not designated for the china CARES program. AIDS Patient Care STDS (2008) 0.94
Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms. J Physiol (2003) 0.94
Prescribed intensity design for extended sources in three-dimensional rotational geometry. Opt Lett (2015) 0.92
Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease. J Neurochem (2006) 0.92
Repression of interferon-gamma expression in T cells by Prospero-related homeobox protein. Cell Res (2008) 0.90
Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition. Cancer Sci (2009) 0.90
Characterization of oligophrenin-1, a RhoGAP lost in patients affected with mental retardation: lentiviral injection in organotypic brain slice cultures. Methods Enzymol (2008) 0.89
How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation. Development (2011) 0.88
Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation. Mol Cell Biol (2011) 0.87
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One (2013) 0.86
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS One (2013) 0.86
The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi. PLoS One (2012) 0.86
Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Mol Cancer (2014) 0.85
Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification. FEBS Lett (2008) 0.85
A beta-herpesvirus with fluorescent capsids to study transport in living cells. PLoS One (2012) 0.84
The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Dev Biol (2002) 0.84
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest (2015) 0.84
Insular cortical and amygdaloid fibers are in contact with posterolateral hypothalamic neurons projecting to the nucleus of the solitary tract in the rat. Brain Res (2006) 0.83
Glutamatergic lateral parabrachial neurons innervate orexin-containing hypothalamic neurons in the rat. Brain Res (2010) 0.83
[Electroacupuncture at Zhongji (CV 3) for treatment of benign hyperplasia of prostate: a multi-central randomized controlled study]. Zhongguo Zhen Jiu (2008) 0.82
Central amygdaloid axon terminals are in contact with retrorubral field neurons that project to the parvicellular reticular formation of the medulla oblongata in the rat. Brain Res (2009) 0.82
Dialogue between RhoA/ROCK and members of the Par complex in cell polarity. Dev Cell (2008) 0.81
Propofol inhibits proliferation and induces neuroapoptosis of hippocampal neurons in vitro via downregulation of NF-κB p65 and Bcl-2 and upregulation of caspase-3. Cell Biochem Funct (2014) 0.80
TLR4 is required for the obesity-induced pancreatic beta cell dysfunction. Acta Biochim Biophys Sin (Shanghai) (2013) 0.80
The RASputin effect. Genes Dev (2002) 0.79
[Effects of needle knife relaxing therapy on tension of local soft tissue and pain of osteoarthritis of knee]. Zhongguo Zhen Jiu (2008) 0.78
DOK2 inhibits EGFR-mutated lung adenocarcinoma. PLoS One (2013) 0.78
Integrative genomic analyses of recepteur d'origine nantais and its prognostic value in cancer. Int J Mol Med (2013) 0.78
Driving actin dynamics under the influence of alcohol. Cell (2006) 0.78
Intraoperative CD133+ cell transplantation during coronary artery bypass grafting in ischemic cardiomyopathy. Multimed Man Cardiothorac Surg (2010) 0.78
Mutations of the transcription factor FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome. Genet Test Mol Biomarkers (2009) 0.77
[Physiological characteristics of a low-pH tolerant strain Torulopsis glabrata RT-6]. Wei Sheng Wu Xue Bao (2011) 0.77
Water-forming NADH oxidase protects Torulopsis glabrata against hyperosmotic stress. Yeast (2010) 0.77
[Use of periocular superficial musculo-aponeurotic system flap and hard palate mucosal graft in reconstruction of full-thickness eyelid defects]. Zhonghua Yan Ke Za Zhi (2007) 0.77
A light and electron microscopic analysis of the convergent insular cortical and amygdaloid projections to the posterior lateral hypothalamus in the rat, with special reference to cardiovascular function. Neurosci Res (2006) 0.76
[Effects of propofol on expression of hippocampal survivin and Caspase-3 in newborn rats]. Zhonghua Er Ke Za Zhi (2012) 0.76
Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Int J Oncol (2013) 0.76
Tris(aceto-nitrile-κN)dichlorido(tri-phenyl-phosphane-κP)ruthenium(II) aceto-nitrile monosolvate. Acta Crystallogr Sect E Struct Rep Online (2013) 0.75
Optical design and system engineering of a multiresolution foveated laparoscope. Appl Opt (2016) 0.75
[The effects of tympanotomy tube insertion on distortion product otoacoustic emissions]. Lin Chuang Er Bi Yan Hou Ke Za Zhi (2004) 0.75
[Advances of studies on acupuncture reinforcing-reducing of twirling-rotating the needle]. Zhongguo Zhen Jiu (2008) 0.75
Using cDNA-representational difference analysis (cDNA-RDA) in combination with microarrays to identify Rac regulated genes. Methods Mol Biol (2002) 0.75
[Efficacy of reconstruction for congenital microphthalmos]. Zhonghua Yan Ke Za Zhi (2011) 0.75
[Experimental study of the biocompatible and osteoinductive behavior of the hydroxyapatite/ultra-high molecular weight polyethtlene composite]. Zhonghua Zheng Xing Wai Ke Za Zhi (2004) 0.75
[Effects of simulated weightlessness on reproduction in male rats]. Space Med Med Eng (Beijing) (2003) 0.75
Agenesis of right hepatic lobe accompanied by cirrhosis of the left hepatic lobe and portal hypertension. Am Surg (2012) 0.75
Signaling mechanisms. Curr Opin Neurobiol (2010) 0.75