Published in Mol Cell Biol on September 18, 2006
Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis. Blood (2011) 1.84
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2. Nat Struct Mol Biol (2014) 1.64
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol (2007) 1.34
Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J (2010) 1.32
EPO receptor circuits for primary erythroblast survival. Blood (2008) 1.26
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood (2008) 1.20
Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance. Genes Cancer (2010) 1.03
The effect of erythropoietin on normal and neoplastic cells. Biologics (2012) 0.98
Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2. Blood (2012) 0.97
Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage. FASEB J (2012) 0.93
The effects of erythropoietin dose titration during high-fat diet-induced obesity. J Biomed Biotechnol (2011) 0.92
Erythropoietin signaling promotes transplanted progenitor cell survival. FASEB J (2009) 0.90
Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. PLoS One (2011) 0.88
JAK2 activation by growth hormone and other cytokines. Biochem J (2015) 0.85
EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors. PLoS One (2010) 0.85
Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles. Biophys J (2014) 0.84
Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. J Biol Chem (2011) 0.84
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses. Biochem J (2014) 0.83
Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles. Sci Rep (2015) 0.81
Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis. Expert Opin Ther Targets (2015) 0.81
SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci (2015) 0.78
The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Structure (2016) 0.78
In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. PLoS One (2015) 0.76
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04
Jak2 is essential for signaling through a variety of cytokine receptors. Cell (1998) 5.92
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell (1998) 4.77
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Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol (2005) 2.82
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell (2001) 2.10
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell (2003) 1.84
The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. Mol Cell (2001) 1.72
The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J (2001) 1.67
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Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol (2003) 1.05
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Dimer- and oligomerization of the erythropoietin receptor by disulfide bond formation and significance of the region near the WSXWS motif in intracellular transport. Arch Biochem Biophys (1993) 0.90
Quality control of receptor-kinase signaling complexes. Dev Cell (2002) 0.81
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol (2003) 3.45
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev (2002) 3.16
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol (2002) 2.70
Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Endocr Rev (2005) 2.31
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell (2009) 2.28
Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell (2005) 2.26
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature (2008) 2.10
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood (2002) 1.96
Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol (2004) 1.96
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity (2004) 1.77
Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem (2001) 1.56
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J (2003) 1.47
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J (2002) 1.38
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem (2004) 1.35
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol (2007) 1.34
Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J (2010) 1.32
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol (2004) 1.16
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J (2006) 1.11
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol (2002) 1.10
FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways. Cell Signal (2003) 1.03
Determination of the transphosphorylation sites of Jak2 kinase. Biochem Biophys Res Commun (2004) 1.03
Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells. FEBS Lett (2011) 0.97
A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine (2006) 0.94
Dermatophagoides farinae extract induces severe atopic dermatitis in NC/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment. Int Immunopharmacol (2009) 0.93
Proteolipid protein 2 is associated with melanoma metastasis. Oncol Rep (2010) 0.92
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO J (2002) 0.89
Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway. Cell Signal (2008) 0.89
IFN-gamma induces apoptosis in developing mast cells. J Immunol (2005) 0.89
Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol (2009) 0.88
The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol (2004) 0.88
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway. Mol Endocrinol (2008) 0.87
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS One (2007) 0.87
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43. J Neurosci (2012) 0.87
Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation. Blood (2003) 0.87
Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. Blood (2005) 0.86
Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. Cell Signal (2009) 0.86
The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice. Int Immunopharmacol (2009) 0.84
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice. J Biol Chem (2006) 0.83
Evi-1 expression in Xenopus. Gene Expr Patterns (2005) 0.83
Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation. Cell Signal (2011) 0.81
Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3. Biol Pharm Bull (2003) 0.81
KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. J Biol Chem (2010) 0.81
Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells. Free Radic Res (2009) 0.81
Coffee inhibits adipocyte differentiation via inactivation of PPARγ. Biol Pharm Bull (2014) 0.80
Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol (2010) 0.78
Dynamin isoforms decode action potential firing for synaptic vesicle recycling. J Biol Chem (2013) 0.77
TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species. Biochem Biophys Res Commun (2006) 0.77
Knockdown of proteolipid protein 2 or focal adhesion kinase with an artificial microRNA reduces growth and metastasis of B16BL6 melanoma cells. Oncol Lett (2011) 0.76
Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs. Cell Signal (2013) 0.75
[DDX5 is a novel targeting protein of tumor suppressor ARF]. Seikagaku (2016) 0.75
C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation. Cell Signal (2005) 0.75
Dexamethasone suppresses neurosteroid biosynthesis via downregulation of steroidogenic enzyme gene expression in human glioma GI-1 cells. Biol Pharm Bull (2014) 0.75