Published in J Biol Chem on December 13, 2001
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev (2003) 2.62
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A (2005) 2.38
Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med (2012) 1.99
VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci (2006) 1.65
VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev (2005) 1.53
A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev Biol (2009) 1.45
Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood (2007) 1.39
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet (2011) 1.35
Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet (2014) 1.33
An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda) (2012) 1.21
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med (2009) 1.21
Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res (2006) 1.14
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation (2009) 1.09
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A (2007) 1.08
PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors. BMC Biol (2004) 1.04
Regulating angiogenesis at the level of PtdIns-4,5-P2. EMBO J (2006) 1.00
Molecular and developmental biology of the hemangioblast. Dev Dyn (2008) 0.99
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res (2008) 0.99
GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. Arterioscler Thromb Vasc Biol (2008) 0.98
The phospholipase C isozymes and their regulation. Subcell Biochem (2012) 0.97
Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol (2010) 0.96
The ubiquitin-proteasome system meets angiogenesis. Mol Cancer Ther (2012) 0.94
Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Blood (2007) 0.93
Role of c-Cbl-dependent regulation of phospholipase Cgamma1 activation in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2010) 0.92
TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells. J Biol Chem (2008) 0.91
c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1. Oncogene (2011) 0.91
Epo-induced erythroid maturation is dependent on Plcγ1 signaling. Cell Death Differ (2014) 0.90
A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS One (2009) 0.86
Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations. Int J Mol Sci (2013) 0.84
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling. PLoS One (2011) 0.82
Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1. Blood (2012) 0.81
ISG15 modulates development of the erythroid lineage. PLoS One (2011) 0.80
Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. Biochemistry (2012) 0.77
The "Ets" factor: vessel formation in zebrafish--the missing link? PLoS Biol (2006) 0.77
Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma. Oncotarget (2016) 0.77
Expression of phosphoinositide-specific phospholipase C isoforms in native endothelial cells. PLoS One (2015) 0.76
Sodium and potassium regulate endothelial phospholipase C-γ and Bmx. Am J Physiol Renal Physiol (2014) 0.76
Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma. Sci Rep (2017) 0.75
PLCγ1 controls osteoclast numbers via CSF-1-dependent diacylglycerol/β-catenin/cyclinD1 pathway. J Biol Chem (2016) 0.75
IP3 receptor signaling and endothelial barrier function. Cell Mol Life Sci (2017) 0.75
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell (2006) 3.73
SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol (2003) 3.45
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev (2002) 3.16
The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell (2009) 2.90
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol (2002) 2.70
Retinoic acid from the meninges regulates cortical neuron generation. Cell (2009) 2.46
ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol (2006) 2.39
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell (2009) 2.28
Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell (2005) 2.26
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc Natl Acad Sci U S A (2007) 2.20
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature (2008) 2.10
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol (2006) 2.06
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev (2003) 2.01
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell (2007) 1.99
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood (2002) 1.96
Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol (2004) 1.96
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity (2004) 1.77
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int (2013) 1.71
Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo. Kidney Int (2011) 1.70
Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS One (2008) 1.66
Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression. Circ Res (2006) 1.66
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J (2003) 1.47
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J (2002) 1.38
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem (2004) 1.35
Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem Biophys Res Commun (2008) 1.35
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol (2007) 1.34
Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J (2010) 1.32
Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell (2009) 1.31
Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol (2006) 1.23
The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J Biol Chem (2008) 1.22
Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A (2011) 1.20
The role of protease activity in ErbB biology. Exp Cell Res (2008) 1.20
Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. Cancer Res (2003) 1.19
Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor. Cancer Res (2009) 1.19
Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem (2003) 1.17
Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function. Mol Cell Biol (2006) 1.16
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol (2004) 1.16
Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage. J Biol Chem (2002) 1.15
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin. J Biol Chem (2011) 1.14
The Foxc2 transcription factor regulates tumor angiogenesis. Biochem Biophys Res Commun (2010) 1.11
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J (2006) 1.11
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol (2002) 1.10
Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. J Surg Res (2007) 1.06
ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. J Biol Chem (2006) 1.05
EGF-dependent association of phospholipase C-gamma1 with c-Cbl. Exp Cell Res (2002) 1.04
Determination of the transphosphorylation sites of Jak2 kinase. Biochem Biophys Res Commun (2004) 1.03
Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment. J Biol Chem (2005) 1.00
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res (2008) 0.99
A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest (2014) 0.98
Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci (2005) 0.98
A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine (2006) 0.94
Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovasc Res (2009) 0.92
Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. J Biol Chem (2004) 0.92
Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis (2012) 0.92
Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J Clin Invest (2014) 0.91
Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci (2005) 0.90
ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains. Biochem Biophys Res Commun (2006) 0.90
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO J (2002) 0.89
Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway. Cell Signal (2008) 0.89
The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol (2004) 0.88
Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open (2013) 0.87
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS One (2007) 0.87
Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. Kidney Int (2012) 0.87
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43. J Neurosci (2012) 0.87
Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation. Blood (2003) 0.87
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway. Mol Endocrinol (2008) 0.87
Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res (2013) 0.86
Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. Blood (2005) 0.86
Murine Notch1 is required for lymphatic vascular morphogenesis during development. Dev Dyn (2014) 0.86
The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol (2006) 0.83
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice. J Biol Chem (2006) 0.83
Evi-1 expression in Xenopus. Gene Expr Patterns (2005) 0.83
Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation. J Clin Invest (2016) 0.82
Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. J Mol Cell Cardiol (2012) 0.82
Hesr2 knockout mice develop aortic valve disease with advancing age. Arterioscler Thromb Vasc Biol (2013) 0.82
Regulated intramembrane cleavage of the EGF receptor. Traffic (2012) 0.81
Activation of invariant natural killer T cells impedes liver regeneration by way of both IFN-γ- and IL-4-dependent mechanisms. Hepatology (2014) 0.80
Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin beta3 expression. Cell Adh Migr (2009) 0.79
FOXC1 is enriched in the mammary luminal progenitor population, but is not necessary for mouse mammary ductal morphogenesis. Biol Reprod (2013) 0.79
PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion. J Cell Sci (2002) 0.78
Contrasting role of phospholipase C-gamma1 in the expression of immediate early genes induced by epidermal or platelet-derived growth factors. Exp Cell Res (2006) 0.78
Identification of proteolytic fragments from ErbB-2 that induce apoptosis. Oncogene (2005) 0.78
FoxC1-dependent regulation of vascular endothelial growth factor signaling in corneal avascularity. Trends Cardiovasc Med (2012) 0.76
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2. Cells Tissues Organs (2016) 0.75
Lymphatic vessel development: fluid flow and valve-forming cells. J Clin Invest (2015) 0.75
Animal models of alcoholic liver disease: Pathogenesis and clinical relevance. Gene Expr (2017) 0.75
[The mechanisms of high-phosphate-induced vascular calcification in patients with chronic kidney disease]. Sheng Li Ke Xue Jin Zhan (2014) 0.75
Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3. Br J Haematol (2002) 0.75
[Efficient isolation of mesenchymal stem cells from human bone marrow by direct plating method combined with modified primary explant culture]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2013) 0.75