Published in J Cell Biol on September 18, 2006
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma. J Biol Chem (2008) 1.74
The signaling mechanisms of syndecan heparan sulfate proteoglycans. Curr Opin Cell Biol (2009) 1.53
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol (2006) 1.33
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J (2013) 1.24
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics. Front Oncol (2014) 1.08
Lacritin and other new proteins of the lacrimal functional unit. Exp Eye Res (2008) 1.08
Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Invest Ophthalmol Vis Sci (2011) 1.06
Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells. Invest Ophthalmol Vis Sci (2013) 0.95
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. J Biol Chem (2013) 0.91
Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity. Invest Ophthalmol Vis Sci (2013) 0.87
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity. J Biol Chem (2013) 0.87
Lacritin and the tear proteome as natural replacement therapy for dry eye. Exp Eye Res (2013) 0.87
Pathogen induced changes in the protein profile of human tears from Fusarium keratitis patients. PLoS One (2013) 0.86
Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment. Invest Ophthalmol Vis Sci (2012) 0.84
A cleavage-potentiated fragment of tear lacritin is bactericidal. J Biol Chem (2014) 0.84
Dry eye and designer ophthalmics. Optom Vis Sci (2008) 0.84
Focus on molecules: lacritin. Exp Eye Res (2007) 0.82
Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci (2014) 0.80
Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med (2014) 0.79
Lacritin and other autophagy associated proteins in ocular surface health. Exp Eye Res (2015) 0.77
Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin. Invest Ophthalmol Vis Sci (2013) 0.77
Focus on molecules: syndecan-1. Exp Eye Res (2010) 0.76
A thermo-responsive protein treatment for dry eyes. J Control Release (2014) 0.76
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr D Biol Crystallogr (2015) 0.76
Molecular Functions of Glycoconjugates in Autophagy. J Mol Biol (2016) 0.75
Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling. BMC Cancer (2015) 0.75
Focus on molecules: heparanase. Exp Eye Res (2010) 0.75
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem (2001) 7.87
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92
A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate. J Chromatogr (1971) 3.51
Specificities of heparan sulphate proteoglycans in developmental processes. Nature (2000) 3.46
Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. Cancer Res (2005) 2.68
Developmental changes in heparan sulfate expression: in situ detection with mAbs. J Cell Biol (1992) 2.61
Syndecans: proteoglycan regulators of cell-surface microdomains? Nat Rev Mol Cell Biol (2003) 2.36
Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Nat Genet (2000) 2.23
The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells. J Cell Biol (2004) 1.91
Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J Biol Chem (2003) 1.83
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med (1998) 1.76
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis. Matrix Biol (2004) 1.75
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem (2005) 1.66
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member. Biochem Biophys Res Commun (2000) 1.59
Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J Cell Biol (2005) 1.51
cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J Mol Biol (2001) 1.44
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A (2003) 1.41
Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts. J Cell Sci (2006) 1.39
Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Exp Cell Res (2003) 1.36
Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells. J Biol Chem (2002) 1.36
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol (2006) 1.33
Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion. J Biol Chem (2003) 1.23
Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression. Biochemistry (2004) 1.21
Detection of circulating breast tumor cells by differential expression of marker genes. Clin Cancer Res (2002) 1.20
Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix. J Cell Physiol (1987) 1.19
Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas. Jpn J Cancer Res (2001) 1.10
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells. Cancer Res (2001) 1.09
A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4. J Biol Chem (2001) 1.09
Identification of an adhesion site within the syndecan-4 extracellular protein domain. J Biol Chem (1997) 1.07
Characterization of the high affinity cell-binding domain in the cell surface proteoglycan syndecan-4. J Biol Chem (1998) 0.99
Heparanase regulates murine hair growth. Am J Pathol (2005) 0.97
Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chains that are apparently structurally indistinguishable. J Biol Chem (2003) 0.96
Identification of an invasion regulatory domain within the core protein of syndecan-1. J Biol Chem (2004) 0.94
Solution structure of parathyroid hormone related protein (residues 1-34) containing an Ala substituted for an Ile in position 15 (PTHrP[Ala15]-(1-34)). J Biol Chem (1997) 0.86
A synthetic glycosaminoglycan mimetic (RGTA) modifies natural glycosaminoglycan species during myogenesis. J Cell Sci (2005) 0.85
Organogenesis of the exocrine gland. Dev Biol (2004) 0.84
Laminin E8 alveolarization site: heparin sensitivity, cell surface receptors, and role in cell spreading. Am J Physiol (1997) 0.84
The alpha-helical domain near the amino terminus is essential for dimerization of vascular endothelial growth factor. J Biol Chem (1998) 0.83
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. Blood (2004) 2.32
The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells. J Cell Biol (2004) 1.91
Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes Dev (2004) 1.89
Syndecans in tumor cell adhesion and signaling. Reprod Biol Endocrinol (2004) 1.88
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med (2009) 1.83
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem (2005) 1.66
Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood (2010) 1.61
Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly. J Cell Biol (2003) 1.55
Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia. Am J Hum Genet (2013) 1.52
Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts. J Cell Sci (2006) 1.39
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nat Genet (2012) 1.38
Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Exp Cell Res (2003) 1.36
Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors. J Biol Chem (2006) 1.35
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol (2006) 1.33
The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Invest Ophthalmol Vis Sci (2005) 1.27
A polymer scaffold for protein oligomerization. J Am Chem Soc (2004) 1.11
Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis. J Invest Dermatol (2002) 1.10
Lacritin and other new proteins of the lacrimal functional unit. Exp Eye Res (2008) 1.08
Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci (2010) 1.06
Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Invest Ophthalmol Vis Sci (2011) 1.06
Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction. Lab Invest (2006) 1.04
miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts. J Invest Dermatol (2012) 1.04
Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem (2010) 1.01
Syndecan-1 transmembrane and extracellular domains have unique and distinct roles in cell spreading. J Biol Chem (2003) 0.98
ald of Mycobacterium tuberculosis encodes both the alanine dehydrogenase and the putative glycine dehydrogenase. J Bacteriol (2011) 0.97
Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals. J Biol Chem (2004) 0.97
Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. J Biol Chem (2002) 0.96
Clustering of syndecan-4 and integrin beta1 by laminin alpha 3 chain-derived peptide promotes keratinocyte migration. Mol Biol Cell (2009) 0.95
Roles of cytosolic Hsp70 and Hsp40 molecular chaperones in post-translational translocation of presecretory proteins into the endoplasmic reticulum. J Biol Chem (2002) 0.95
Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem (2002) 0.95
Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Matrix Biol (2003) 0.95
Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A. J Cell Biochem (2003) 0.94
Biological activities of homologous loop regions in the laminin alpha chain G domains. J Biol Chem (2003) 0.93
Identification of neurite outgrowth promoting sites on the laminin alpha 3 chain G domain. Biochemistry (2002) 0.92
Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium. Clin Cancer Res (2005) 0.92
Identification of biologically active sequences in the laminin alpha 4 chain G domain. J Biol Chem (2002) 0.91
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. J Biol Chem (2013) 0.91
Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J Biol Chem (2004) 0.91
T-cadherin enhances cell-matrix adhesiveness by regulating beta1 integrin trafficking in cutaneous squamous carcinoma cells. Genes Cells (2007) 0.90
4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species. Toxicol Sci (2006) 0.90
Syndecan-1 ectodomain regulates matrix-dependent signaling in human breast carcinoma cells. Exp Cell Res (2004) 0.89
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity. J Biol Chem (2013) 0.87
Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity. Invest Ophthalmol Vis Sci (2013) 0.87
Lacritin and the tear proteome as natural replacement therapy for dry eye. Exp Eye Res (2013) 0.87
Activation of p38 MAPK suppresses matrix metalloproteinase-1 gene expression induced by platelet-derived growth factor. Arch Dermatol Res (2003) 0.87
Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid. Biochem Biophys Res Commun (2009) 0.87
Syndecan binding sites in the laminin alpha1 chain G domain. Biochemistry (2003) 0.87
Tear lacritin levels by age, sex, and time of day in healthy adults. Invest Ophthalmol Vis Sci (2012) 0.86
Laminin alpha3 LG4 module induces keratinocyte migration: involvement of matrix metalloproteinase-9. J Recept Signal Transduct Res (2005) 0.86
Knockdown of Fat2 by siRNA inhibits the migration of human squamous carcinoma cells. J Dermatol Sci (2008) 0.86
Direct regulation of rRNA transcription by fibroblast growth factor 2. Mol Cell Biol (2005) 0.86
The role of dermatopontin in the stromal organization of the cornea. Invest Ophthalmol Vis Sci (2006) 0.85
Organogenesis of the exocrine gland. Dev Biol (2004) 0.84
An ex vivo model employing keloid-derived cell-seeded collagen sponges for therapy development. J Invest Dermatol (2012) 0.84
Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment. Invest Ophthalmol Vis Sci (2012) 0.84
Dry eye and designer ophthalmics. Optom Vis Sci (2008) 0.84
Mutational analysis of the respiratory nitrate transporter NarK2 of Mycobacterium tuberculosis. PLoS One (2012) 0.83
Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. J Biol Chem (2012) 0.83
Adult-onset multiple eccrine angiomatous hamartoma in enlarging hairy plaques. Acta Derm Venereol (2007) 0.82
Focus on molecules: lacritin. Exp Eye Res (2007) 0.82
Cytoprotective effect of lacritin on human corneal epithelial cells exposed to benzalkonium chloride in vitro. Curr Eye Res (2014) 0.82
Application of a two-question screening instrument to detect depressive symptoms in patients with vitiligo: a pilot study. J Am Acad Dermatol (2011) 0.81
Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptides. Biochemistry (2004) 0.81
Phacomatosis pigmentokeratotica without extracutaneous abnormalities. Dermatology (2003) 0.81
Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. J Mol Biol (2002) 0.80
Dissemination of panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Okinawa, Japan. J Dermatol (2012) 0.80
Purification and characterization of a recombinant Yersinia pestis V-F1 "Reversed" fusion protein for use as a new subunit vaccine against plague. Protein Expr Purif (2010) 0.79
Expression and purification of a biologically active basic fibroblast growth factor fusion protein. Protein Expr Purif (2003) 0.79
Definitions of the physical properties of pressure ulcers and characterisation of their regional variance. Int Wound J (2012) 0.78
Primary localized cutaneous nodular amyloidosis in a patient with Sjögren's syndrome: a review of the literature. J Dermatol (2005) 0.78
Yersinia pestis outer membrane type III secretion protein YscC: expression, purification, characterization, and induction of specific antiserum. Protein Expr Purif (2005) 0.78
Sacral pressure ulcer successfully treated with traction, resulting in a reduction of wound deformity. Int Wound J (2012) 0.78
Bullous dermatosis associated with IgG antibodies specific for desmocollins. Eur J Dermatol (2010) 0.78
Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning. J Immunotoxicol (2013) 0.78
Mutation analyses of patients with dyschromatosis symmetrica hereditaria: five novel mutations of the ADAR1 gene. J Dermatol Sci (2010) 0.78
Calcification of the placenta in a woman with pseudoxanthoma elasticum with a mutation of the ABCC6 gene. J Dermatol (2014) 0.77
Incorporation of basic fibroblast growth factor into preconfluent cultured skin substitute to accelerate neovascularisation and skin reconstruction after transplantation. Scand J Plast Reconstr Surg Hand Surg (2007) 0.77
Localization of the laminin alpha4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin alpha4 chain C-terminal LG4 module. J Invest Dermatol (2004) 0.77
Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin. Invest Ophthalmol Vis Sci (2013) 0.77