The alpha-helical domain near the amino terminus is essential for dimerization of vascular endothelial growth factor.

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J Cell Biol (2006) 1.62

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol (2006) 1.33

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. Blood (2010) 0.93

Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis. Bioeng Transl Med (2017) 0.75

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood (1996) 5.31

Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res (2000) 3.02

Calmodulin activation of plant microsomal Ca uptake. Proc Natl Acad Sci U S A (1980) 2.94

Red Light-enhanced Phytochrome Pelletability: Re-examination and Further Characterization. Plant Physiol (1976) 2.77

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem (1993) 2.62

Turnover of phytochrome in pumpkin cotyledons. Plant Physiol (1973) 2.58

ATP-dependent Ca uptake into plant membrane vesicles. Proc Natl Acad Sci U S A (1978) 2.24

Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer (1999) 2.17

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res (1996) 2.10

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene (1994) 2.01

De novo synthesis of phytochrome in pumpkin hooks. Plant Physiol (1973) 1.89

Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem Biophys Res Commun (1995) 1.87

Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J (2001) 1.83

Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res (2000) 1.79

Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum (2001) 1.74

In Vivo Properties of Membrane-bound Phytochrome. Plant Physiol (1974) 1.73

Particle-bound phytochrome from maize and pumpkin. Nat New Biol (1973) 1.72

Activation of plant quinate:NAD 3-oxidoreductase by Ca and calmodulin. Proc Natl Acad Sci U S A (1983) 1.70

Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem (1995) 1.65

AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem Biophys Res Commun (1992) 1.60

Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol (2005) 1.57

Specific binding of the calcium antagonist [3H]verapamil to membrane fractions from plants. J Biol Chem (1985) 1.54

Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A (1993) 1.44

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene (1997) 1.44

Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1. J Biol Chem (1997) 1.41

Oncogenes as inducers of tumor angiogenesis. Cancer Metastasis Rev (1995) 1.39

Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis. Breast Cancer Res Treat (1995) 1.26

Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors. Angiogenesis (2001) 1.25

Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res (1992) 1.24

New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J Med Chem (2000) 1.21

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells. J Cell Biochem (1994) 1.18

Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Cancer Res (1999) 1.17

VEGF-mediated tumour angiogenesis: a new target for cancer therapy. Curr Opin Biotechnol (1995) 1.16

Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome. J Clin Endocrinol Metab (1995) 1.15

Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res (1997) 1.10

Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood. Angiogenesis (2001) 1.08

Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes. Eur J Biochem (1993) 1.03

Sequence of human protein kinase C alpha. Nucleic Acids Res (1990) 1.01

Binding properties of the plant photoreceptor phytochrome to membranes. J Supramol Struct (1974) 0.98

Purification and identification of calmodulin from Neurospora crassa. FEBS Lett (1981) 0.98

Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells. J Biol Chem (1992) 0.97

Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies. Ann Oncol (1995) 0.97

Expression of the vascular endothelial growth factor gene is inhibited by p73. Oncogene (2000) 0.97

Myosin heavy chain kinase inactivated by Ca2+/calmodulin from aggregating cells of Dictyostelium discoideum. EMBO J (1983) 0.97

Calmodulin from neurospora crassa. General properties and conformational changes. J Biol Chem (1982) 0.96

Active interaction of human A375 melanoma cells with the lymphatics in vivo. Histochem Cell Biol (2000) 0.95

Expression of biologically active isoforms of the tumor angiogenesis factor VEGF in Escherichia coli. Biochem Biophys Res Commun (1996) 0.95

VEGF121 induces proliferation of vascular endothelial cells and expression of flk-1 without affecting lymphatic vessels of chorioallantoic membrane. Dev Biol (1996) 0.92

Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis? Neurosurgery (1994) 0.92

An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells. Proc Natl Acad Sci U S A (1998) 0.92

Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively. Genomics (1996) 0.89

Inducible overexpression of human protein kinase C alpha in NIH 3T3 fibroblasts results in growth abnormalities. Cell Signal (1992) 0.88

Pertussis toxin inhibits the angiotensin II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta. FEBS Lett (1987) 0.88

The pivotal role of VEGF in tumor angiogenesis: molecular facts and therapeutic opportunities. Cancer Metastasis Rev (1998) 0.87

Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate. Biochem J (1993) 0.86

Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells. Eur J Biochem (1993) 0.86

Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro. Biochim Biophys Acta (2000) 0.85

High-efficiency expression of rat protein kinase C-gamma in baculovirus-infected insect cells. FEBS Lett (1990) 0.84

A Ca2+, Calmodulin-dependent NAD kinase from corn is located in the outer mitochondrial membrane. J Biol Chem (1984) 0.83

3,4,5-Triiodobenzoic acid affects [3H]verapamil binding to plant and animal membrane fractions and smooth muscle contraction. Biochem Biophys Res Commun (1986) 0.82

Anti-microtubular herbicides and fungicides affect Ca(2+) transport in plant mitochondria. Planta (1980) 0.82

Inducible expression of human phospholipase C-gamma 2 and its activation by platelet-derived growth factor B-chain homodimer and platelet-derived growth factor A-chain homodimer in transfected NIH 3T3 fibroblasts. Eur J Biochem (1992) 0.81

Synthetic diacylglycerols induce a rise of quin2-detectable free intracellular calcium in human platelets. FEBS Lett (1987) 0.80

Donor stromal cells from human blood engraft in NOD/SCID mice. Blood (2000) 0.80

Phorbol 12,13-dibutyrate-induced contraction of isolated rabbit vascular smooth muscle. Eur J Pharmacol (1987) 0.80

Calmodulin-dependent and independent NAD kinase activities from cytoplasmic and chloroplastic fractions of spinach (Spinacia oleracea L.). Plant Cell Rep (1982) 0.80

Ca(2+) transport in mitochondrial and microsomal fractions from higher plants. Planta (1980) 0.79

Calmodulin-stimulated cyclic nucleotide phosphodiesterase from Neurospora crassa. Biochim Biophys Acta (1983) 0.79

Stereoselective inhibition of calmodulin-dependent cAMP phosphodiesterase from bovine heart by (+)- and (-)-nimodipine. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.79

Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo. Carcinogenesis (1995) 0.78

Angiotensin II mediates intracellular signalling in vascular smooth muscle cells by activation of tyrosine-specific protein kinases and c-raf-1. Biochem Biophys Res Commun (1993) 0.78

Phytochrome: First-order phototransformation kinetics in vivo. Planta (1973) 0.78

A new set of regulatory molecules in plants: A plant phospholipid similar to platelet-activating factor stimulates protein kinase and proton-translocating ATPase in membrane vesicles. Planta (1988) 0.78

Identification of calmodulin in the green alga Mougeotia and its possible function in chloroplast reorientational movement. Planta (1984) 0.77

Novel antibodies directed against the extracellular domain of the human VEGF-receptor type II. Hybridoma (1997) 0.77

Pertussis toxin inhibits angiotensin II-mediated phosphatidylinositol breakdown and ADP-ribosylates a 40 Kd protein in cultured smooth muscle cells. Biochem Biophys Res Commun (1988) 0.77

Chemiluminescence immunoassay for vascular endothelial growth factor (vascular permeability factor) in tumor-tissue homogenates. Clin Chem (1996) 0.77

Over-expression of human phospholipase C-gamma 2 enhances platelet-derived growth factor-induced mobilization of intracellular Ca2+ and the release of arachidonic acid and prostaglandins in NIH 3T3 fibroblasts. FEBS Lett (1992) 0.77

Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter. FEBS Lett (1996) 0.77

Calcium-binding and its effect on circular dichroism of plant calmodulin. Planta (1985) 0.76

The effect of calmodulin and far-red light on the kinetic properties of the mitochondrial and microsomal calcium-ion transport system from corn. Planta (1983) 0.76

Herbicides and fungicides stimulate Ca2+ efflux from rat liver mitochondria. FEBS Lett (1981) 0.76

Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells. Antiviral Res (1993) 0.76

Over-expression of protein kinase C-alpha enhances platelet-derived growth factor- and phorbol ester- but not calcium ionophore-induced formation of prostaglandins in NIH 3T3 fibroblasts. FEBS Lett (1993) 0.76