Published in J Biol Chem on September 25, 2006
Heme enzyme structure and function. Chem Rev (2014) 1.58
Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase. J Am Chem Soc (2010) 1.45
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain. FEBS J (2009) 1.39
A connecting hinge represses the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 1.32
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins. J Biol Chem (2008) 1.25
Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase. J Biol Chem (2009) 1.25
Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry (2009) 1.22
Regulation of interdomain electron transfer in the NOS output state for NO production. Dalton Trans (2009) 1.01
NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. Arch Biochem Biophys (2012) 1.00
Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc Natl Acad Sci U S A (2013) 1.00
Calmodulin-induced structural changes in endothelial nitric oxide synthase. FEBS Lett (2012) 0.98
Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J (2011) 0.98
Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase. J Biol Chem (2010) 0.97
Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions. Coord Chem Rev (2011) 0.97
Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling. J Biol Chem (2011) 0.97
Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex. J Biol Chem (2009) 0.96
A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. J Biol Chem (2010) 0.96
Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. Free Radic Biol Med (2010) 0.96
Molecular architecture of mammalian nitric oxide synthases. Proc Natl Acad Sci U S A (2014) 0.93
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem (2008) 0.91
Mutations in the FMN domain modulate MCD spectra of the heme site in the oxygenase domain of inducible nitric oxide synthase. J Am Chem Soc (2009) 0.90
Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation. J Biol Chem (2009) 0.87
Energy landscapes and catalysis in nitric-oxide synthase. J Biol Chem (2014) 0.87
Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains. J Biol Chem (2012) 0.85
Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase. Biochem J (2013) 0.85
Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases. J Inorg Biochem (2013) 0.84
Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase. Inorg Chem (2013) 0.83
Intraprotein electron transfer between the FMN and heme domains in endothelial nitric oxide synthase holoenzyme. Biochim Biophys Acta (2011) 0.82
Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis. FEBS J (2013) 0.79
Dissecting structural and electronic effects in inducible nitric oxide synthase. Biochem J (2015) 0.78
Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics. J Biol Chem (2016) 0.77
Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study. J Inorg Biochem (2015) 0.76
Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis. J Biol Chem (2017) 0.75
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery. FEBS J (2016) 0.75
Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science (2009) 4.41
Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. Science (2012) 2.80
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol Cell (2003) 2.78
Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions. Genes Dev (2010) 2.60
Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A (2007) 2.44
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. J Biol Chem (2004) 2.28
Identification of a new cryptochrome class. Structure, function, and evolution. Mol Cell (2003) 2.11
Science education. Educating future scientists. Science (2003) 1.97
Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation. J Biol Chem (2006) 1.90
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute. Nucleic Acids Res (2002) 1.89
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J Mol Biol (2003) 1.82
Nickel superoxide dismutase structure and mechanism. Biochemistry (2004) 1.66
Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. J Biol Chem (2002) 1.63
Tetrahydrobiopterin radical enzymology. Chem Rev (2003) 1.50
Bacterial nitric-oxide synthases operate without a dedicated redox partner. J Biol Chem (2008) 1.41
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures. Proc Natl Acad Sci U S A (2003) 1.41
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis. J Biol Chem (2002) 1.41
Tetrameric architecture of the circadian clock protein KaiB. A novel interface for intermolecular interactions and its impact on the circadian rhythm. J Biol Chem (2005) 1.39
Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death. J Neurosci (2007) 1.38
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. J Biol Chem (2004) 1.37
Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J (2003) 1.37
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc Natl Acad Sci U S A (2009) 1.36
Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes. J Biol Chem (2003) 1.35
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis. J Mol Biol (2008) 1.32
A connecting hinge represses the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 1.32
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proc Natl Acad Sci U S A (2001) 1.30
Structure of a nitric oxide synthase heme protein from Bacillus subtilis. Biochemistry (2002) 1.29
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. J Mol Biol (2007) 1.26
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol (2008) 1.25
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins. J Biol Chem (2008) 1.25
Direct observation of a photoinduced radical pair in a cryptochrome blue-light photoreceptor. Angew Chem Int Ed Engl (2009) 1.24
Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol (2004) 1.24
Evidence that light modulates protein nitration in rat retina. Mol Cell Proteomics (2002) 1.22
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase. J Biol Chem (2006) 1.22
Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry (2009) 1.22
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. J Mol Biol (2002) 1.20
Structural tuning of the fluorescent protein iLOV for improved photostability. J Biol Chem (2012) 1.19
GAPDH regulates cellular heme insertion into inducible nitric oxide synthase. Proc Natl Acad Sci U S A (2010) 1.17
PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry. J Mol Biol (2006) 1.17
Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors. J Biol Chem (2001) 1.14
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. J Biol Chem (2008) 1.11
Light-induced conformational changes in full-length Arabidopsis thaliana cryptochrome. J Mol Biol (2011) 1.11
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles. J Biol Chem (2004) 1.09
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation. Biochemistry (2005) 1.08
Structural chemistry of a green fluorescent protein Zn biosensor. J Am Chem Soc (2002) 1.07
FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. Elife (2014) 1.07
Abnormalities in nitric oxide and its derivatives in lung cancer. Am J Respir Crit Care Med (2005) 1.07
Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C. Protein Sci (2002) 1.06
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation. J Am Chem Soc (2006) 1.06
Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase. J Biol Chem (2004) 1.05
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase. J Biol Chem (2003) 1.04
Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase. J Am Chem Soc (2007) 1.04
Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis. J Mol Biol (2004) 1.04
Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase. J Biol Chem (2006) 1.04
Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Mol Cell (2012) 1.01
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry. Biochemistry (2005) 1.01
CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Nat Struct Biol (2003) 1.01
Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail. Biochemistry (2007) 1.00
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. Biochemistry (2005) 0.99
The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain. J Biol Chem (2004) 0.99
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radic Biol Med (2008) 0.99
The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis. J Am Chem Soc (2007) 0.99
Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J (2011) 0.98
Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase. J Biol Chem (2010) 0.97
C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. J Biol Chem (2005) 0.97
Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex. J Biol Chem (2009) 0.96
A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. J Biol Chem (2010) 0.96
Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. Free Radic Biol Med (2010) 0.96
Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proc Natl Acad Sci U S A (2005) 0.95
Structural insights into protein-metal ion partnerships. Curr Opin Struct Biol (2004) 0.95
Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. J Am Chem Soc (2005) 0.94
Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase. J Am Chem Soc (2005) 0.92
Variable electron transfer pathways in an amphibian cryptochrome: tryptophan versus tyrosine-based radical pairs. J Biol Chem (2013) 0.92
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem (2008) 0.91
Amyotrophic lateral sclerosis: update and new developments. Degener Neurol Neuromuscul Dis (2012) 0.91
Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis. J Biol Chem (2003) 0.90
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis. J Am Chem Soc (2006) 0.90
Photoisomerization and proton transfer in photoactive yellow protein. J Am Chem Soc (2003) 0.90
Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry (2006) 0.90
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation. J Biol Chem (2005) 0.89
Origin of light-induced spin-correlated radical pairs in cryptochrome. J Phys Chem B (2010) 0.89
Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Arch Biochem Biophys (2009) 0.89
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase. Biochemistry (2003) 0.89
Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer. J Biol Chem (2009) 0.89