Published in Diabetes on October 01, 2006
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Genetic mapping in human disease. Science (2008) 15.12
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
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TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes (2007) 2.20
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes (2009) 1.83
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Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ (2007) 1.80
Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. Diabetes (2007) 1.79
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Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet (2007) 1.59
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet (2007) 1.52
Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. J Health Popul Nutr (2017) 1.38
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Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk. Cancer Causes Control (2008) 1.28
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Genetic analysis of adult-onset autoimmune diabetes. Diabetes (2011) 1.22
Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J Clin Endocrinol Metab (2009) 1.17
TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women. Am J Clin Nutr (2009) 1.17
Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) (2015) 1.16
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab (2010) 1.16
Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med (2006) 1.15
Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes (2009) 1.15
Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J Biol Chem (2012) 1.13
Developmental origins of adult disease. Pediatr Clin North Am (2009) 1.13
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab (2007) 1.12
TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet (2014) 1.10
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LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. Cell Metab (2013) 1.08
Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. PLoS One (2009) 1.08
Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population. BMC Med Genet (2008) 1.04
TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program. PLoS One (2011) 1.04
Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population. BMC Med Genet (2008) 1.02
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum Mol Genet (2014) 1.02
Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diabet Med (2015) 1.02
Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. J Nutr (2009) 1.01
Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes. Diabetologia (2012) 0.99
Pharmacogenetics of Anti-Diabetes Drugs. Pharmaceuticals (Basel) (2010) 0.97
Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet (2010) 0.96
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Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis. PLoS One (2011) 0.95
Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. Diabetologia (2012) 0.94
Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. PLoS One (2010) 0.94
TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes. BMC Med Genet (2011) 0.94
TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population. BMC Med Genet (2008) 0.93
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective. Cell Biosci (2012) 0.93
The search for genetic risk factors of type 2 diabetes mellitus. Diabetes Metab J (2011) 0.92
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Prime suspect: the TCF7L2 gene and type 2 diabetes risk. J Clin Invest (2007) 0.92
The TCF7L2 locus and type 1 diabetes. BMC Med Genet (2007) 0.89
Association of gene variants with susceptibility to type 2 diabetes among Omanis. World J Diabetes (2015) 0.87
Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon. J Diabetes Metab Disord (2015) 0.87
Genetics talks to epigenetics? The interplay between sequence variants and chromatin structure. Curr Genomics (2010) 0.86
Current challenges in the bioinformatics of single cell genomics. Front Oncol (2014) 0.86
TCF7L2 polymorphism associates with new-onset diabetes after transplantation. J Am Soc Nephrol (2009) 0.86
Pharmacogenetics of oral antidiabetic drugs. Int J Endocrinol (2013) 0.86
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC Med Genet (2008) 0.85
Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol Metab (2014) 0.85
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Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis. Nutrients (2015) 0.85
Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. J Clin Endocrinol Metab (2008) 0.84
Stochastic model search with binary outcomes for genome-wide association studies. J Am Med Inform Assoc (2012) 0.83
Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population. Genet Mol Biol (2012) 0.83
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nat Commun (2016) 0.82
Genetic susceptibility to type 2 diabetes and implications for therapy. J Diabetes Sci Technol (2009) 0.82
Pharmacogenetics: potential role in the treatment of diabetes and obesity. Expert Opin Pharmacother (2008) 0.82
Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study. Clin Transl Med (2015) 0.82
Genetics, environment, and diabetes-related end-stage renal disease in the Canary Islands. Genet Test Mol Biomarkers (2012) 0.82
Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome. J Assist Reprod Genet (2009) 0.82
NeuroD1 A45T and PAX4 R121W polymorphisms are associated with plasma glucose level of repaglinide monotherapy in Chinese patients with type 2 diabetes. Br J Clin Pharmacol (2012) 0.81
Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide. Int J Endocrinol (2013) 0.81
The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner. Biochem Biophys Res Commun (2010) 0.80
Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy. BMC Nephrol (2013) 0.80
Association of TCF7L2 allelic variations with gastric function, satiation, and GLP-1 levels. Clin Transl Sci (2011) 0.79
Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis (2012) 0.79
The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. BMC Med Genet (2010) 0.78
Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder. Schizophr Res (2009) 0.78
Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies. BMC Med Genet (2009) 0.78
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes. PLoS One (2016) 0.77
The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis. Clinics (Sao Paulo) (2015) 0.77
Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity. Eur J Hum Genet (2010) 0.77
Cumulative Effect of Common Genetic Variants Predicts Incident Type 2 Diabetes: A Study of 21,183 Subjects from Three Large Prospective Cohorts. Epidemiology (Sunnyvale) (2011) 0.77
New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol (2015) 0.77
Role of pancreatic transcription factors in maintenance of mature β-cell function. Int J Mol Sci (2015) 0.77
Peripheral Artery Disease and Aortic Disease. Glob Heart (2016) 0.75
A principal components-based clustering method to identify variants associated with complex traits. Hum Hered (2011) 0.75
Genetic association analysis of LARS2 with type 2 diabetes. Diabetologia (2009) 0.75
From genotype to human β cell phenotype and beyond. Islets (2012) 0.75
The new perspectives on genetic studies of type 2 diabetes and thyroid diseases. Curr Genomics (2013) 0.75
Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro. Chin Med (2014) 0.75
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Res (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28