Published in Proc Natl Acad Sci U S A on September 29, 2006
3' UTRs are the primary regulators of gene expression in the C. elegans germline. Curr Biol (2008) 3.39
A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness. Genome Res (2010) 2.87
A family of poly(U) polymerases. RNA (2007) 2.15
RNA-specific ribonucleotidyl transferases. RNA (2007) 2.15
FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Genetics (2009) 1.52
GLD-4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line. PLoS Genet (2014) 1.44
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development (2010) 1.41
A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons. Neuron (2009) 1.37
Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast. J Biol Chem (2010) 1.37
GLD2 poly(A) polymerase is required for long-term memory. Proc Natl Acad Sci U S A (2008) 1.31
Progression from a stem cell-like state to early differentiation in the C. elegans germ line. Proc Natl Acad Sci U S A (2010) 1.28
Specificity factors in cytoplasmic polyadenylation. Wiley Interdiscip Rev RNA (2013) 1.15
Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans. Genes Dev (2009) 1.13
GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program. Proc Natl Acad Sci U S A (2010) 1.10
Antagonism between GLD-2 binding partners controls gamete sex. Dev Cell (2009) 1.10
Stem cell proliferation versus meiotic fate decision in Caenorhabditis elegans. Adv Exp Med Biol (2013) 1.07
Germline stem cells: origin and destiny. Cell Stem Cell (2012) 1.04
Molecular regulation of the mitosis/meiosis decision in multicellular organisms. Cold Spring Harb Perspect Biol (2011) 1.04
Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet (2011) 1.02
A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts. Mol Biol Cell (2010) 0.99
Independent recruitments of a translational regulator in the evolution of self-fertile nematodes. Proc Natl Acad Sci U S A (2011) 0.96
Conserved mRNA-binding proteomes in eukaryotic organisms. Nat Struct Mol Biol (2015) 0.93
Determinants of substrate specificity in RNA-dependent nucleotidyl transferases. Biochim Biophys Acta (2007) 0.91
Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. J Biol Chem (2014) 0.89
Proteasomal regulation of the proliferation vs. meiotic entry decision in the Caenorhabditis elegans germ line. Genetics (2008) 0.89
Increased sensitivity and accuracy of a single-stranded DNA splint-mediated ligation assay (sPAT) reveals poly(A) tail length dynamics of developmentally regulated mRNAs. RNA Biol (2014) 0.89
Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform. RNA (2010) 0.88
GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions. PLoS Genet (2009) 0.88
mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans. Cell Res (2011) 0.88
Glucose-Regulated Phosphorylation of the PUF Protein Puf3 Regulates the Translational Fate of Its Bound mRNAs and Association with RNA Granules. Cell Rep (2015) 0.86
New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing. Wiley Interdiscip Rev RNA (2013) 0.84
The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms. Nucleic Acids Res (2014) 0.84
Tissue-specific transcriptomics and proteomics of a filarial nematode and its Wolbachia endosymbiont. BMC Genomics (2015) 0.83
Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation. Mol Reprod Dev (2012) 0.82
Context-dependent function of a conserved translational regulatory module. Development (2012) 0.82
A novel candidate cis-regulatory motif pair in the promoters of germline and oogenesis genes in C. elegans. Genome Res (2011) 0.80
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification. BMB Rep (2016) 0.80
Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc Natl Acad Sci U S A (2015) 0.80
POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster. Mol Biol Cell (2012) 0.79
Translational activation maintains germline tissue homeostasis during adulthood. Worm (2015) 0.79
Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. RNA (2016) 0.77
Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans. Genetics (2016) 0.76
Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. PLoS Genet (2015) 0.75
Polyadenylation is the key aspect of GLD-2 function in C. elegans. RNA (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature (1997) 4.34
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Nature (2002) 3.90
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. Nature (2002) 3.54
Messenger RNA deadenylylation precedes decapping in mammalian cells. Proc Natl Acad Sci U S A (1997) 3.51
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell (2004) 3.10
A history of poly A sequences: from formation to factors to function. Prog Nucleic Acid Res Mol Biol (2002) 2.93
Spindle dynamics and the role of gamma-tubulin in early Caenorhabditis elegans embryos. Mol Biol Cell (2001) 2.87
NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Curr Biol (1999) 2.75
GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development. Dev Biol (1996) 2.55
The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J (1999) 2.54
Genetic regulation of entry into meiosis in Caenorhabditis elegans. Development (1998) 2.28
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell (2002) 2.23
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development (1996) 2.20
Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev (2001) 2.19
FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Dev Cell (2004) 2.03
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics (2004) 1.92
Trans-splicing of nematode premessenger RNA. Annu Rev Microbiol (1993) 1.88
GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans. Dev Cell (2002) 1.78
Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development (2003) 1.78
Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc Natl Acad Sci U S A (2002) 1.75
Germline proliferation and its control. WormBook (2005) 1.73
Vertebrate GLD2 poly(A) polymerases in the germline and the brain. RNA (2005) 1.51
LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans. EMBO J (2005) 1.40
RNA turnover: unexpected consequences of being tailed. Curr Biol (2005) 1.21
Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics (2005) 1.11
Asymmetric and symmetric stem-cell divisions in development and cancer. Nature (2006) 7.32
A PUF family portrait: 3'UTR regulation as a way of life. Trends Genet (2002) 5.71
Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science (2009) 5.55
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Nature (2002) 3.90
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. Nature (2002) 3.54
PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol (2006) 2.89
Multifunctional deadenylase complexes diversify mRNA control. Nat Rev Mol Cell Biol (2008) 2.73
A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. Cell (2005) 2.26
Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line. Mol Biol Cell (2006) 2.23
Binding specificity and mRNA targets of a C. elegans PUF protein, FBF-1. RNA (2005) 2.17
A family of poly(U) polymerases. RNA (2007) 2.15
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Nature (2012) 2.04
FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Dev Cell (2004) 2.03
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics (2004) 1.92
Mammalian GLD-2 homologs are poly(A) polymerases. Proc Natl Acad Sci U S A (2004) 1.88
Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Curr Biol (2006) 1.87
PUF protein-mediated deadenylation is catalyzed by Ccr4p. J Biol Chem (2006) 1.87
GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans. Dev Cell (2002) 1.78
Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans. Curr Biol (2013) 1.72
A single spacer nucleotide determines the specificities of two mRNA regulatory proteins. Nat Struct Mol Biol (2005) 1.67
Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator. Proc Natl Acad Sci U S A (2010) 1.66
RNA-protein interactions in the yeast three-hybrid system: affinity, sensitivity, and enhanced library screening. RNA (2004) 1.64
Two yeast PUF proteins negatively regulate a single mRNA. J Biol Chem (2007) 1.63
Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2. Curr Biol (2002) 1.63
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol (2008) 1.63
Translational repression by deadenylases. J Biol Chem (2010) 1.62
Analyzing mRNA-protein complexes using a yeast three-hybrid system. Methods (2002) 1.60
POP-1 controls axis formation during early gonadogenesis in C. elegans. Development (2002) 1.58
PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila. Development (2008) 1.56
FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Genetics (2009) 1.52
Vertebrate GLD2 poly(A) polymerases in the germline and the brain. RNA (2005) 1.51
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genet (2007) 1.51
Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline. Philos Trans R Soc Lond B Biol Sci (2003) 1.48
A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Nat Struct Mol Biol (2012) 1.47
GON-1 and fibulin have antagonistic roles in control of organ shape. Curr Biol (2004) 1.45
Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Proc Natl Acad Sci U S A (2009) 1.40
LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans. EMBO J (2005) 1.40
A 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs. Proc Natl Acad Sci U S A (2009) 1.40
Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB. Development (2005) 1.38
The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics (2004) 1.37
Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.36
What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA (2008) 1.32
GLD2 poly(A) polymerase is required for long-term memory. Proc Natl Acad Sci U S A (2008) 1.31
Progression from a stem cell-like state to early differentiation in the C. elegans germ line. Proc Natl Acad Sci U S A (2010) 1.28
A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity. RNA (2008) 1.25
Scratching the niche that controls Caenorhabditis elegans germline stem cells. Semin Cell Dev Biol (2009) 1.22
Cooperativity in RNA-protein interactions: global analysis of RNA binding specificity. Cell Rep (2012) 1.22
Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. Proc Natl Acad Sci U S A (2005) 1.22
A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway. Dev Cell (2009) 1.17
The C. elegans Hand gene controls embryogenesis and early gonadogenesis. Development (2003) 1.15
The oogenic germline starvation response in C. elegans. PLoS One (2011) 1.14
Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans. Genes Dev (2009) 1.13
A single C. elegans PUF protein binds RNA in multiple modes. RNA (2009) 1.12
Chemical reprogramming of Caenorhabditis elegans germ cell fate. Nat Chem Biol (2009) 1.11
GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program. Proc Natl Acad Sci U S A (2010) 1.10
Antagonism between GLD-2 binding partners controls gamete sex. Dev Cell (2009) 1.10
Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site. Proc Natl Acad Sci U S A (2012) 1.10
Translational repression by PUF proteins in vitro. RNA (2010) 1.09
The C. elegans adult male germline: stem cells and sexual dimorphism. Dev Biol (2010) 1.04
Autoregulation of GLD-2 cytoplasmic poly(A) polymerase. RNA (2006) 1.04
Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket. J Biol Chem (2011) 1.04
A three-hybrid screen identifies mRNAs controlled by a regulatory protein. RNA (2006) 1.03
Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet (2011) 1.02
Targeted translational regulation using the PUF protein family scaffold. Proc Natl Acad Sci U S A (2011) 1.02
Stacking interactions in PUF-RNA complexes. RNA (2011) 1.00
Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance. Proc Natl Acad Sci U S A (2014) 0.98
RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem (2012) 0.98
Evolution of discrete Notch-like receptors from a distant gene duplication in Caenorhabditis. Evol Dev (2002) 0.97
The C. elegans SYS-1 protein is a bona fide beta-catenin. Dev Cell (2008) 0.97
The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophys J (2011) 0.97
TRA-1/GLI controls development of somatic gonadal precursors in C. elegans. Development (2004) 0.97
Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line. Dev Dyn (2007) 0.97
Chapter 14. Analysis of RNA-protein interactions using a yeast three-hybrid system. Methods Enzymol (2008) 0.95
Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program. Proc Natl Acad Sci U S A (2011) 0.94
Tethered function assays using 3' untranslated regions. Methods (2002) 0.93
Cyclin D regulation of a sexually dimorphic asymmetric cell division. Dev Cell (2005) 0.93
The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. J Cell Sci (2013) 0.92
gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Genetics (2005) 0.92
Germline stem cells and their regulation in the nematode Caenorhabditis elegans. Adv Exp Med Biol (2013) 0.91
Atrial fibrillation is associated with cardiac hypoxia. Cardiovasc Pathol (2009) 0.90
Translational control in the Caenorhabditis elegans germ line. Adv Exp Med Biol (2013) 0.90
Identification of a conserved interface between PUF and CPEB proteins. J Biol Chem (2012) 0.90