PubRank

Peter H Krammer

Author PubWeight™ 161.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2002 5.87
2 Death receptors in chemotherapy and cancer. Oncogene 2004 2.64
3 Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005 2.28
4 Death receptor signaling. J Cell Sci 2005 2.21
5 Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med 2008 2.18
6 Caspases: pharmacological manipulation of cell death. J Clin Invest 2005 2.10
7 Immune escape of tumors: apoptosis resistance and tumor counterattack. J Leukoc Biol 2002 2.04
8 Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med 2004 1.95
9 c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem 2005 1.93
10 The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med 2006 1.91
11 TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J 2005 1.90
12 TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle 2007 1.84
13 Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum 2006 1.83
14 Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res 2006 1.82
15 The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. Chem Biol 2012 1.82
16 Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology 2010 1.75
17 Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol 2007 1.74
18 In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol 2005 1.58
19 Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol 2010 1.57
20 Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol Cell 2012 1.57
21 Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem 2007 1.55
22 Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med 2004 1.54
23 Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer 2002 1.46
24 The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. Int J Cancer 2007 1.45
25 Pillars article: T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J. Exp. Med. 1982. 155: 734-748. J Immunol 2013 1.43
26 p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun 2005 1.42
27 Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res 2003 1.42
28 One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat 2007 1.41
29 The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 2003 1.41
30 Molecular mechanisms of treg-mediated T cell suppression. Front Immunol 2012 1.41
31 Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One 2007 1.40
32 Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction. BMC Cancer 2006 1.35
33 Concepts of activated T cell death. Crit Rev Oncol Hematol 2008 1.33
34 Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol 2010 1.33
35 Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 2003 1.32
36 IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 2002 1.32
37 Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes. Hepatology 2009 1.31
38 Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol 2010 1.30
39 Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene 2003 1.28
40 High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade. Blood 2011 1.28
41 Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology 2004 1.28
42 Apoptosis in cancer--implications for therapy. Semin Oncol 2004 1.27
43 Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J Immunol 2005 1.26
44 Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J Virol 2003 1.23
45 Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. Int J Oncol 2006 1.20
46 Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol 2007 1.20
47 Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood 2007 1.20
48 How T lymphocytes switch between life and death. Eur J Immunol 2006 1.20
49 T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep 2012 1.16
50 Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol 2007 1.14
51 Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection. J Hepatol 2003 1.11
52 HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood 2006 1.10
53 CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus. Arch Dermatol Res 2008 1.10
54 Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci 2002 1.09
55 Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. Blood 2006 1.09
56 Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system. Semin Immunol 2003 1.09
57 Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis. Blood 2006 1.08
58 Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol Ther 2007 1.07
59 Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation. J Immunol 2003 1.06
60 Regulation of T cell apoptosis during the immune response. Curr Mol Med 2002 1.06
61 HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death. J Immunol 2005 1.06
62 Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. Cancer Res 2009 1.06
63 Death receptor signaling and its function in the immune system. Curr Dir Autoimmun 2006 1.05
64 Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 2010 1.05
65 Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. Blood 2007 1.05
66 A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes. Immunity 2012 1.03
67 Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Proc Natl Acad Sci U S A 2009 1.02
68 Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells. J Biol Chem 2002 1.01
69 Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death. EMBO J 2005 0.99
70 Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 2005 0.99
71 Tumor counterattack: fact or fiction? Cancer Immunol Immunother 2005 0.99
72 Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells. Cancer Res 2005 0.99
73 Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways. Biochem Biophys Res Commun 2010 0.99
74 Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. Sci Signal 2011 0.98
75 CD95 stimulation results in the formation of a novel death effector domain protein-containing complex. J Biol Chem 2008 0.98
76 Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells. J Immunol 2011 0.98
77 Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. J Biol Chem 2011 0.97
78 CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. J Invest Dermatol 2009 0.97
79 Vitamin E inhibits IL-4 gene expression in peripheral blood T cells. Eur J Immunol 2002 0.97
80 Understanding apoptosis by systems biology approaches. Mol Biosyst 2009 0.97
81 Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort. J Immunol 2004 0.96
82 Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice. Magn Reson Med 2006 0.94
83 A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation. Mol Cell Biol 2009 0.94
84 An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death. J Immunol 2003 0.94
85 Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death. J Clin Invest 2002 0.93
86 HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway. Oncogene 2004 0.93
87 Lack of T-cell receptor-induced signaling is crucial for CD95 ligand up-regulation and protects cutaneous T-cell lymphoma cells from activation-induced cell death. Cancer Res 2009 0.93
88 Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients. PLoS One 2011 0.93
89 Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis. Oncogene 2002 0.92
90 FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35. J Neurosci 2005 0.92
91 The life and death of a B cell. Adv Cancer Res 2002 0.92
92 Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family. Biochem Biophys Res Commun 2009 0.92
93 Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals. J Neurol Sci 2006 0.91
94 LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J Biol Chem 2008 0.91
95 Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha. Eur J Immunol 2004 0.90
96 FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome. J Invest Dermatol 2009 0.90
97 Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter. J Immunol 2002 0.90
98 Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation. PLoS One 2011 0.89
99 NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells. Eur J Immunol 2004 0.89
100 An unexpected role for FosB in activation-induced cell death of T cells. Oncogene 2003 0.89
101 Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem 2001 0.87
102 2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation. Proc Natl Acad Sci U S A 2012 0.87
103 ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 2010 0.87
104 A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria. PLoS Genet 2011 0.87
105 Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma. Biochem Biophys Res Commun 2010 0.86
106 Histone deacetylase inhibitor-induced sensitization to TNFalpha/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression. Int J Cancer 2010 0.86
107 Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs. Int J Cancer 2013 0.86
108 Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas. Int J Cancer 2011 0.86
109 Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation. J Biol Chem 2012 0.85
110 Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis. Exp Dermatol 2011 0.85
111 Enhancement of cisplatin-induced apoptosis by infection with adeno-associated virus type 2. Int J Cancer 2002 0.85
112 Transforming growth factor beta can mediate apoptosis via the expression of TRAIL in human hepatoma cells. Hepatology 2005 0.84
113 Construction of optimized bispecific antibodies for selective activation of the death receptor CD95. Cancer Res 2008 0.84
114 Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 2007 0.84
115 Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. Int J Cancer 2009 0.84
116 The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T. Eur J Immunol 2002 0.84
117 Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. Int J Cancer 2014 0.83
118 Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4. J Biol Chem 2009 0.83
119 Inhibition of NF-κB induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells. FEBS Lett 2010 0.82
120 Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo. Int J Cancer 2004 0.82
121 Specificity of anti-human CD95 (APO-1/Fas) antibodies. Biochem Biophys Res Commun 2002 0.82
122 Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. PLoS One 2013 0.81
123 Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways. J Immunol 2005 0.81
124 CREB function is required for normal thymic cellularity and post-irradiation recovery. Eur J Immunol 2004 0.81
125 The chains of death: a new view on caspase-8 activation at the DISC. Cell Cycle 2012 0.81
126 Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus. Exp Dermatol 2010 0.81
127 Mitochondria as oxidative signaling organelles in T-cell activation: physiological role and pathological implications. Arch Immunol Ther Exp (Warsz) 2013 0.81
128 Interferon-α abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis. J Rheumatol 2013 0.80
129 Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1. Mol Cancer Res 2008 0.80
130 In vitro generated human memory-like T cells are CD95 type II cells and resistant towards CD95-mediated apoptosis. Eur J Immunol 2006 0.80
131 The influence of CD95L expression on tumor rejection in mice. Eur J Immunol 2003 0.80
132 CD95L mediates tumor counterattack in vitro but induces neutrophil-independent tumor rejection in vivo. Int J Cancer 2005 0.80
133 The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer 2013 0.79
134 The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells. Int J Cancer 2013 0.78
135 Lack of proapoptotic activity of soluble CD95 ligand is due to its failure to induce CD95 oligomers. J Interferon Cytokine Res 2003 0.77
136 Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus: analysis using tissue microarray. Exp Dermatol 2013 0.77
137 Understanding life and death at CD95. Adv Exp Med Biol 2011 0.77
138 Life and Death Decisions in the CD95 System: Main Pro-and Anti-Apoptotic Modulators. Acta Naturae 2009 0.75