Published in Genes Dev on November 01, 2010
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet (2015) 2.46
Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63
The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev (2010) 1.50
YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle (2012) 1.34
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci U S A (2011) 1.27
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
PTPN14 is required for the density-dependent control of YAP1. Genes Dev (2012) 1.23
WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis (2011) 1.09
ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells. Cell Death Differ (2013) 1.05
PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS One (2011) 1.01
Tumour suppressor genes in chemotherapeutic drug response. Biosci Rep (2012) 0.99
The p53 control of apoptosis and proliferation: lessons from Drosophila. Apoptosis (2014) 0.93
microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway. Mol Cancer (2014) 0.90
Regulation and function of the TAZ transcription co-activator. Int J Biochem Mol Biol (2011) 0.87
The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth. Biol Open (2013) 0.83
RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome? Mol Biol Int (2012) 0.83
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development. Nat Commun (2016) 0.83
p53- and p73-independent activation of TIGAR expression in vivo. Cell Death Dis (2015) 0.80
ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. PLoS One (2014) 0.80
A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. Cell Death Dis (2015) 0.79
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J (2011) 0.79
Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines. Cancer Cell Int (2013) 0.78
Echoes of a distant past: The cag pathogenicity island of Helicobacter pylori. Cold Spring Harb Perspect Med (2013) 0.78
TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells. J Biol Chem (2015) 0.78
An identity crisis for a cancer gene: subcellular location determines ASPP1 function. Cancer Cell (2010) 0.75
The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway. J Virol (2015) 0.75
The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation. Cell Cycle (2016) 0.75
YAP tips the balance. Nat Rev Cancer (2010) 0.75
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments. Oncotarget (2015) 0.75
TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis. Biosci Rep (2016) 0.75
MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells. Nat Mater (2016) 0.75
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ (2017) 0.75
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev (2010) 6.05
Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem (2007) 5.49
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55
ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res (2008) 4.33
The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol (2008) 3.63
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell (2007) 3.47
Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A (1994) 3.30
Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem (2008) 2.61
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Mol Cell (2005) 2.45
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet (2003) 2.41
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev (2006) 2.41
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet (2006) 2.20
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol (2007) 2.13
ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer (2007) 1.94
ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol (2004) 1.88
YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease. Biochem Cell Biol (2009) 1.81
ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell (2010) 1.68
YAP: at the crossroad between transformation and tumor suppression. Cell Cycle (2009) 1.67
Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J Biol Chem (2001) 1.58
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev (2010) 1.50
ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev (2006) 1.49
ASPP [corrected] and cancer. Nat Rev Cancer (2006) 1.38
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. J Clin Oncol (2005) 1.30
Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A (2009) 1.25
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors (2009) 1.23
Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol (2008) 1.14
Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins. J Biol Chem (2009) 1.09
Drosophila ASPP regulates C-terminal Src kinase activity. Dev Cell (2007) 1.03
The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Curr Biol (2009) 1.00
ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. Oncogene (2006) 1.00
The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo. Oncogene (2006) 0.91
New insights into the expanding complexity of the tumor suppressor ASPP2. Cell Cycle (2009) 0.91
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
p73: Friend or foe in tumorigenesis. Nat Rev Cancer (2002) 3.30
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
p53: new roles in metabolism. Trends Cell Biol (2007) 2.69
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol (2007) 1.94
p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol (2009) 1.79
Ubiquitination and degradation of mutant p53. Mol Cell Biol (2007) 1.77
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB. Cell Cycle (2010) 1.67
Phosphorylation of HDM2 by Akt. Oncogene (2002) 1.63
p53, ROS and senescence in the control of aging. Aging (Albany NY) (2010) 1.56
Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mol Cell Biol (2003) 1.51
Complicating the complexity of p53. Carcinogenesis (2005) 1.34
Lucifer's labyrinth--ten years of path finding in cell death. Mol Cell (2007) 1.28
Savior and slayer: the two faces of p53. Nat Med (2005) 1.27
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest (2007) 1.27
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol (2012) 1.21
Modifications of p53: competing for the lysines. Curr Opin Genet Dev (2009) 1.20
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A (2012) 1.19
The role of p53 in glucose metabolism. Curr Opin Cell Biol (2010) 1.16
p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53. Cell Cycle (2008) 1.16
The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta (2013) 1.12
Induction of p57(KIP2) expression by p73beta. Proc Natl Acad Sci U S A (2002) 1.11
Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53. Cancer Res (2004) 1.09
Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem (2013) 1.07
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
Regulation of the p53 pathway by ubiquitin and related proteins. Int J Biochem Cell Biol (2010) 1.04
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis (2008) 1.02
Cancer: guarding the guardian? Nature (2004) 1.02
p73-alpha is capable of inducing scotin and ER stress. Oncogene (2004) 1.02
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation. Nat Cell Biol (2007) 1.01
HDM2 phosphorylation by MAPKAP kinase 2. Oncogene (2005) 0.98
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle (2011) 0.96
A role for Numb in p53 stabilization. Genome Biol (2008) 0.91
Small molecules that bind the Mdm2 RING stabilize and activate p53. Carcinogenesis (2012) 0.87
Tumor suppression by p53: fall of the triumvirate? Cell (2012) 0.84
Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorg Med Chem (2006) 0.82
Cancer: pinning a change on p53. Nature (2002) 0.81
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J (2011) 0.79
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability. FEBS Lett (2012) 0.78
p53 and Mdm2: an auld alliance. Cell Cycle (2010) 0.77
The secret life of histones. Cell (2003) 0.77
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy (2014) 0.77
5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorg Med Chem (2013) 0.75
Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature (2017) 0.75