Published in Science on October 06, 2006
Decoding protein modifications using top-down mass spectrometry. Nat Methods (2007) 2.62
Mass spectrometry for proteomics. Curr Opin Chem Biol (2008) 2.31
Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. J Proteome Res (2011) 2.17
Protein analysis by shotgun/bottom-up proteomics. Chem Rev (2013) 2.13
Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state. Proc Natl Acad Sci U S A (2009) 2.10
Stepwise evolution of protein native structure with electrospray into the gas phase, 10(-12) to 10(2) s. Proc Natl Acad Sci U S A (2008) 1.91
Chemistry. Mass spectrometry: bottom-up or top-down? Science (2006) 1.90
Finding one's way in proteomics: a protein species nomenclature. Chem Cent J (2009) 1.75
Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. J Am Chem Soc (2013) 1.69
Collisions or electrons? Protein sequence analysis in the 21st century. Anal Chem (2009) 1.62
Top-down mass spectrometry: recent developments, applications and perspectives. Analyst (2011) 1.50
Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. Anal Chem (2010) 1.40
Augmented phosphorylation of cardiac troponin I in hypertensive heart failure. J Biol Chem (2011) 1.38
Accurate mass measurements in proteomics. Chem Rev (2007) 1.36
Comprehensive analysis of protein modifications by top-down mass spectrometry. Circ Cardiovasc Genet (2011) 1.34
Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32
A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. J Proteome Res (2009) 1.31
Top-down identification and characterization of biomolecules by mass spectrometry. J Am Soc Mass Spectrom (2008) 1.31
Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis. J Proteome Res (2010) 1.28
Microproteomics: analysis of protein diversity in small samples. Mass Spectrom Rev (2008) 1.26
Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry. J Am Soc Mass Spectrom (2010) 1.22
Origin of supercharging in electrospray ionization of noncovalent complexes from aqueous solution. J Am Soc Mass Spectrom (2009) 1.21
An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications. J Proteome Res (2009) 1.21
Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry. J Muscle Res Cell Motil (2009) 1.19
Nonergodicity in electron capture dissociation investigated using hydrated ion nanocalorimetry. J Am Soc Mass Spectrom (2007) 1.17
Analysis of proteins and peptides on a chromatographic timescale by electron-transfer dissociation MS. FEBS J (2007) 1.14
High-throughput middle-down analysis using an orbitrap. J Proteome Res (2010) 1.10
Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions. J Am Soc Mass Spectrom (2010) 1.10
Sensitive and specific identification of wild type and variant proteins from 8 to 669 kDa using top-down mass spectrometry. Mol Cell Proteomics (2008) 1.09
Top-down proteomics in health and disease: challenges and opportunities. Proteomics (2014) 1.08
Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction. Mol Cell Proteomics (2014) 1.07
Native electrospray and electron-capture dissociation in FTICR mass spectrometry provide top-down sequencing of a protein component in an intact protein assembly. J Am Soc Mass Spectrom (2010) 1.06
Fast top-down intact protein characterization with capillary zone electrophoresis-electrospray ionization tandem mass spectrometry. Anal Chem (2013) 1.06
Bound anions differentially stabilize multiprotein complexes in the absence of bulk solvent. J Am Chem Soc (2011) 1.05
Gas-phase intramolecular protein crosslinking via ion/ion reactions: ubiquitin and a homobifunctional sulfo-NHS ester. J Am Soc Mass Spectrom (2013) 1.04
Electrochemistry-assisted top-down characterization of disulfide-containing proteins. Anal Chem (2012) 1.04
Identification of membrane proteins by tandem mass spectrometry of protein ions. Proc Natl Acad Sci U S A (2007) 1.03
Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions. Mol Syst Biol (2011) 1.03
Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry for top-down characterization of the Mycobacterium marinum secretome. Anal Chem (2014) 1.01
Early structural evolution of native cytochrome c after solvent removal. Chembiochem (2008) 1.00
A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I. Protein Sci (2011) 1.00
Gas-phase chemistry of multiply charged bioions in analytical mass spectrometry. Annu Rev Anal Chem (Palo Alto Calif) (2010) 0.99
Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa. Anal Chem (2012) 0.97
Electrospray ionization mass spectrometry: a technique to access the information beyond the molecular weight of the analyte. Int J Anal Chem (2011) 0.97
Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 automethylation using top-down high resolution tandem mass spectrometry. Protein Sci (2009) 0.96
Sheathless capillary electrophoresis-tandem mass spectrometry for top-down characterization of Pyrococcus furiosus proteins on a proteome scale. Anal Chem (2014) 0.95
Structural characterization of intact proteins is enhanced by prevalent fragmentation pathways rarely observed for peptides. J Am Soc Mass Spectrom (2010) 0.94
Top-down and bottom-up mass spectrometric characterization of human myoglobin-centered free radicals induced by oxidative damage. Anal Chem (2007) 0.94
Ultraviolet photodissociation for characterization of whole proteins on a chromatographic time scale. Anal Chem (2014) 0.94
An insight into high-resolution mass-spectrometry data. Biostatistics (2009) 0.92
Charge State Dependent Fragmentation of Gaseous α-Synuclein Cations via Ion Trap and Beam-Type Collisional Activation. Int J Mass Spectrom (2009) 0.91
Coupling capillary zone electrophoresis with electron transfer dissociation and activated ion electron transfer dissociation for top-down proteomics. Anal Chem (2015) 0.91
Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T. Biochemistry (2011) 0.90
Combining bottom-up and top-down mass spectrometric strategies for de novo sequencing of the crustacean hyperglycemic hormone from Cancer borealis. Anal Chem (2009) 0.90
Revealing ligand binding sites and quantifying subunit variants of noncovalent protein complexes in a single native top-down FTICR MS experiment. J Am Soc Mass Spectrom (2014) 0.90
Proteomics of plant pathogenic fungi. J Biomed Biotechnol (2010) 0.89
Effective protein separation by coupling hydrophobic interaction and reverse phase chromatography for top-down proteomics. Anal Chem (2014) 0.86
Top-down Proteomics: Technology Advancements and Applications to Heart Diseases. Expert Rev Proteomics (2016) 0.86
Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. Curr Opin Chem Biol (2013) 0.85
Performance evaluation of a dual linear ion trap-Fourier transform ion cyclotron resonance mass spectrometer for proteomics research. J Proteomics (2013) 0.85
Electron detachment dissociation for top-down mass spectrometry of acidic proteins. Chemistry (2011) 0.84
Enhanced Dissociation of Intact Proteins with High Capacity Electron Transfer Dissociation. J Am Soc Mass Spectrom (2015) 0.83
A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration. Prog Retin Eye Res (2013) 0.83
Native mass spectrometry of photosynthetic pigment-protein complexes. FEBS Lett (2013) 0.83
Structural heterogeneity of doubly-charged peptide b-ions. J Am Soc Mass Spectrom (2011) 0.82
Negative electrospray droplet exposure to gaseous bases for the manipulation of protein charge state distributions. Anal Chem (2010) 0.82
Top-down mass analysis of protein tyrosine nitration: comparison of electron capture dissociation with "slow-heating" tandem mass spectrometry methods. Anal Chem (2010) 0.81
Tau aggregation in Alzheimer's disease: what role for phosphorylation? Prion (2007) 0.81
Top-down protein characterization facilitated by ion/ion reactions on a quadrupole/time of flight platform. Proteomics (2010) 0.81
Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry. J Am Chem Soc (2014) 0.80
Analysis of protein isoforms: can we do it better? Proteomics (2012) 0.80
In-line separation by capillary electrophoresis prior to analysis by top-down mass spectrometry enables sensitive characterization of protein complexes. J Proteome Res (2014) 0.80
Simultaneous transmission mode collision-induced dissociation and ion/ion reactions for top-down protein identification/characterization using a quadrupole/time-of-flight tandem mass spectrometer. Anal Chem (2009) 0.79
Systems Proteomics View of the Endogenous Human Claudin Protein Family. J Proteome Res (2016) 0.79
Coupling Capillary Zone Electrophoresis to a Q Exactive HF Mass Spectrometer for Top-down Proteomics: 580 Proteoform Identifications from Yeast. J Proteome Res (2016) 0.78
Electron-capture dissociation and ion mobility mass spectrometry for characterization of the hemoglobin protein assembly. Protein Sci (2015) 0.77
Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry. J Muscle Res Cell Motil (2015) 0.77
Real-time HD Exchange Kinetics of Proteins from Buffered Aqueous Solution with Electrothermal Supercharging and Top-Down Tandem Mass Spectrometry. J Am Soc Mass Spectrom (2016) 0.77
Comprehensive Characterization of AMP-Activated Protein Kinase Catalytic Domain by Top-Down Mass Spectrometry. J Am Soc Mass Spectrom (2016) 0.77
Detecting native folds in mixtures of proteins that contain disulfide bonds. Nat Biotechnol (2008) 0.76
Application of clinical proteomics in acute respiratory distress syndrome. Clin Transl Med (2014) 0.75
Alteration of Genetic Make-up in Karnal Bunt Pathogen (Tilletia indica) of Wheat in Presence of Host Determinants. Plant Pathol J (2015) 0.75
Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry. J Am Chem Soc (2002) 2.72
Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue. Proc Natl Acad Sci U S A (2002) 2.62
Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociation. J Am Chem Soc (2002) 2.45
Breakdown of chlorophyll: a nonenzymatic reaction accounts for the formation of the colorless "nonfluorescent" chlorophyll catabolites. Proc Natl Acad Sci U S A (2003) 2.33
Stepwise evolution of protein native structure with electrospray into the gas phase, 10(-12) to 10(2) s. Proc Natl Acad Sci U S A (2008) 1.91
Secondary and tertiary structures of gaseous protein ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy. Proc Natl Acad Sci U S A (2002) 1.85
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry (2003) 1.70
Nonergodic and conformational control of the electron capture dissociation of protein cations. Proc Natl Acad Sci U S A (2004) 1.53
Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics. FEBS J (2007) 1.47
Top down characterization of secreted proteins from Mycobacterium tuberculosis by electron capture dissociation mass spectrometry. J Am Soc Mass Spectrom (2003) 1.41
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. J Am Chem Soc (2005) 1.40
Top-down identification and characterization of biomolecules by mass spectrometry. J Am Soc Mass Spectrom (2008) 1.31
Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry. Biochemistry (2006) 1.28
Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. J Am Chem Soc (2005) 1.25
The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS. Chem Biol (2004) 1.24
A new approach for plant proteomics: characterization of chloroplast proteins of Arabidopsis thaliana by top-down mass spectrometry. Mol Cell Proteomics (2003) 1.24
Chlorophyll breakdown in spinach: on the structure of five nonfluorescent chlorophyll catabolites. Photosynth Res (2002) 1.23
Native electron capture dissociation for the structural characterization of noncovalent interactions in native cytochrome C. Angew Chem Int Ed Engl (2003) 1.21
Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra. Proc Natl Acad Sci U S A (2010) 1.19
Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer. J Bacteriol (2007) 1.15
The thermal unfolding of native cytochrome c in the transition from solution to gas phase probed by native electron capture dissociation. Angew Chem Int Ed Engl (2005) 1.15
Plasma electron capture dissociation for the characterization of large proteins by top down mass spectrometry. Anal Chem (2003) 1.14
How ubiquitin unfolds after transfer into the gas phase. J Am Soc Mass Spectrom (2012) 1.14
The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. J Am Chem Soc (2004) 1.13
Detection of four oxidation sites in viral prolyl-4-hydroxylase by top-down mass spectrometry. Protein Sci (2003) 1.13
Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry (2004) 1.07
Early structural evolution of native cytochrome c after solvent removal. Chembiochem (2008) 1.00
Dissimilarity in the reductive unfolding pathways of two ribonuclease homologues. J Mol Biol (2004) 0.96
Minimizing base loss and internal fragmentation in collisionally activated dissociation of multiply deprotonated RNA. J Am Soc Mass Spectrom (2009) 0.95
Consecutive ion activation for top down mass spectrometry: improved protein sequencing by nozzle-skimmer dissociation. Anal Chem (2005) 0.95
Infrared photodissociation spectroscopy of electrosprayed ions in a Fourier transform mass spectrometer. J Am Chem Soc (2005) 0.92
Top-down mass spectrometry for sequencing of larger (up to 61 nt) RNA by CAD and EDD. J Am Soc Mass Spectrom (2010) 0.91
Triggering of RNA secondary structures by a functionalized nucleobase. Angew Chem Int Ed Engl (2004) 0.91
The dynamics of water evaporation from partially solvated cytochrome c in the gas phase. Phys Chem Chem Phys (2007) 0.90
Transcriptional control of DNA replication licensing by Myc. Sci Rep (2013) 0.89
IgE receptor-mediated alteration of membrane-cytoskeleton interactions revealed by mass spectrometric analysis of detergent-resistant membranes. Biochemistry (2009) 0.89
Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem Soc Trans (2012) 0.88
Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry (2004) 0.86
Charge site mass spectra: conformation-sensitive components of the electron capture dissociation spectrum of a protein. J Am Soc Mass Spectrom (2013) 0.86
Characterization of modified RNA by top-down mass spectrometry. Angew Chem Int Ed Engl (2012) 0.86
Simultaneous characterization of the reductive unfolding pathways of RNase B isoforms by top-down mass spectrometry. Chem Biol (2004) 0.85
Electron detachment dissociation for top-down mass spectrometry of acidic proteins. Chemistry (2011) 0.84
Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit. J Mol Biol (2004) 0.84
Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products. Int J Mass Spectrom (2011) 0.84
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry (2005) 0.83
Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. J Am Soc Mass Spectrom (2005) 0.83
Charge as you like! Efficient manipulation of negative ion net charge in electrospray ionization of proteins and nucleic acids. Eur J Mass Spectrom (Chichester, Eng) (2011) 0.82
Biosynthesis of thiamin thiazole: determination of the regiochemistry of the S/O acyl shift by using 1,4-dideoxy-D-xylulose-5-phosphate. Angew Chem Int Ed Engl (2006) 0.80
Sequencing of specific copolymer oligomers by electron-capture-dissociation mass spectrometry. J Am Chem Soc (2002) 0.80
Proteins with highly similar native folds can show vastly dissimilar folding behavior when desolvated. Angew Chem Int Ed Engl (2013) 0.79
Design of a filter train for precipitate removal in monoclonal antibody downstream processing. Biotechnol Appl Biochem (2009) 0.77
Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy. Chemphyschem (2009) 0.77
Affinity precipitation of a monoclonal antibody from an industrial harvest feedstock using an ELP-Z stimuli responsive biopolymer. Biotechnol Bioeng (2014) 0.76
Femtosecond laser vaporization that preserves protein-folded structure: an unproven idea. Proc Natl Acad Sci U S A (2012) 0.76
Detecting native folds in mixtures of proteins that contain disulfide bonds. Nat Biotechnol (2008) 0.76
Probing Protein Structure and Folding in the Gas Phase by Electron Capture Dissociation. J Am Soc Mass Spectrom (2015) 0.76
Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography. Biotechnol Prog (2013) 0.76
A personal perspective on chemistry-driven RNA research. Biopolymers (2013) 0.76
Focus in honor of Roman Zubarev, recipient of the 2007 Biemann Medal. J Am Soc Mass Spectrom (2008) 0.75
Multi-step evolution of protein conformation on electrospray into the gas phase. Eur J Mass Spectrom (Chichester, Eng) (2010) 0.75
Focus in honor of David E. Clemmer, recipient of the 2006 Biemann medal. J Am Soc Mass Spectrom (2007) 0.75